1.Chronic toxic ellects of herbicide paraquat on rats.
Shinji ASANUMA ; Kiichiro SASAKI ; Eisuke NAITOH ; Kazuo KUROSAWA ; Shousui MATSUSIMA ; Mitsuru ANDO ; Kenji TAMURA ; Shouji YAMAMOTO ; Ichisuke KAWAHARA
Journal of the Japanese Association of Rural Medicine 1990;39(2):71-76
Paraquat is one the most popular herbicides in agriculture in Japan. To study the chronic toxicological effects of paraquat on animals, rats were fed a paraquat-containing diet for 1 year and 2 months (1, 5, 25mg/kg of body weight/day). Paraquat administration induced serious histochemical changes in various organs, such as the lung, heart, kidney and liver in rast. Pulmonary fibrosis occurred in the group of rats given 1mg paraquat/kg of body weight/day in diet.
The alkaline phosphatase activity and creatinine content in the blood serum significantly increased. The concentrations of cholesterol, triglyceride and phospholipid in the serum decreased significantly.
A significant increase of lipid peroxidation was observed in the brain, kidney and liver.
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