1.Advances in epidemiological researches of Herpes zoster
Xinjing MA ; Feixue WEI ; Yingying SU ; Shoujie HUANG ; Ting WU
Chinese Journal of Microbiology and Immunology 2016;36(12):948-953
Herpes zoster ( HZ, also known as shingles) , caused by reactivation of latent varicella zoster virus ( VZV) , is a viral disease characterized by a painful skin rash with blisters involving a limited area. Elderly individuals older than fifty years of age are at increased risk of contracting HZ. In China, HZ becomes a significant health burden along with population aging. The virological characteristics, clinical di-agnosis, epidemiological characteristics of HZ are summarized in this review. Moreover, the burden of HZ, risk factors as well as the prevention and control of HZ are also discussed.
2. The impact of male circumcision on the natural history of genital HPV infection: a prospective cohort study
Feixue WEI ; Meng GUO ; Xinjing MA ; Yue HUANG ; Ya ZHENG ; Lin WANG ; Yan SUN ; Sijie ZHUANG ; Kai YIN ; Yingying SU ; Shoujie HUANG ; Mingqiang LI ; Ting WU ; Jun ZHANG
Chinese Journal of Preventive Medicine 2018;52(5):486-492
Objective:
To analyze the correlation between circumcision and incidence and clearance of male genital HPV infection.
Methods:
From May to July 2014, 18-55 year old men who had sexual behavior history were recruited from the general population in Liuzhou, Guangxi to set up a cohort. Totally, 113 circumcised and 560 uncircumcised men were enrolled and interviewed using a questionnaire (including information on demographic characteristics and sexual behaviors), then they were followed-up with 6-month interval for 2 times. On each visit, specimens of male external genitalia were collected and genotyped for HPV DNA. The differences of incidence and clearance of genital HPV infections between circumcised and uncircumcised men were analyzed by Log-rank test. Cox regression was used to analyze the relationship between circumcision and incidence and clearance of HPV infection.
Results:
The median age (
3.Research progress regarding the clinical evaluation on recombinant human papillomavirus vaccines
Wengang HE ; Jun ZHAO ; Shoujie HUANG ; Ting WU
Chinese Journal of Epidemiology 2016;37(6):904-908
Human papillomavirus (HPV) is the main cause for cervical cancer,anogenital cancers and genital warts.Three HPV vaccines have been licensed abroad.Data from clinical trials showed high efficacy of the HPV vaccines in young women with 90%-100% vaccine-related HPV diseases prevented.Though efficacy of the vaccine appears lower in older women,this population can still benefit from vaccination.Immunobriging trials show that the two-dose schedule in 9-14 years old girls elicits non-inferior immune response than the three-dose one in young adults.In addition,HPV vaccines can reduce the recurrent rates in CIN2 + patients after therapeutic surgery and the vaccines have cross-protection aganist diseases caused by non-vaccine type HPV.Safety data on HPV vaccines are assuring.Thus HPV vaccine should be widely used in adolescent girls and women of appropriate age groups.
4.Blocking effect of SARS-CoV-2 vaccines on virus transmission: current situation and prospect
Xiaohui LIU ; Chunlan ZHUANG ; Qi CHEN ; Shoujie HUANG ; Ting WU
Chinese Journal of Microbiology and Immunology 2022;42(10):753-760
SARS-CoV-2 vaccines are effective in preventing COVID-19, but their efficacy in blocking virus transmission is controversial. Although SARS-CoV-2 vaccines can reduce the sources of infection and the possibility of secondary transmission from breakthrough infection cases, their effectiveness wanes over time. Moreover, the emergence of variants with stronger transmissibility and immune escape ability also poses huge challenges to the effectiveness of SARS-CoV-2 vaccines in blocking virus transmission. Therefore, ending the COVID-19 pandemic still requires the continuous research and development of new vaccines as well as the adoption of effective prevention and control measures.
5.Progress in optimizing the immunization schedule of recombinant human papillomavirus vaccines
Guohua ZHONG ; Shudan SHEN ; Shoujie HUANG ; Ting WU
Chinese Journal of Microbiology and Immunology 2021;41(11):893-900
Human papillomavirus (HPV) is closely associated with cervical cancer and other anogenital cancers or diseases, and HPV vaccination is an important measure of primary prevention. Currently, there are four licensed HPV vaccines. Clinical trials and real-world studies have confirmed the efficacy and effectiveness of the routine three-dose immunization schedule. Expanding HPV vaccination coverage can accelerate the process of cervical cancer elimination, so optimizing the immunization schedule, including extending dosing intervals and decreasing vaccination doses, is one of the key considerations for future application of HPV vaccines. This review summarized the progress related to the immunogenicity and efficacy of HPV vaccination with fewer doses and non-standard three-dose schedule.
6.Research progress in the protective efficacy of human papillomavirus vaccines in males
Yahui WANG-JIANG ; Zhaofeng BI ; Shoujie HUANG ; Ting WU ; Yingying SU
Chinese Journal of Microbiology and Immunology 2023;43(6):485-492
Human papillomavirus (HPV) is one of the most common sexually transmitted pathogens. It can cause a variety of diseases such as condyloma acuminatum, anal cancer, penile cancer and oropharyngeal cancer in men, resulting in a high disease burden. With the development of society, the application of HPV vaccines in males has attracted more attention. Currently, there are many clinical trials and real-world research results of HPV vaccines applied to boys and men worldwide, and many countries have introduced HPV vaccination for underage boys into their national immunization programs. This article intended to review the research progress in the efficacy of HPV vaccines in male population.
7. Seroepidemiologic study of hepatitis E virus infection in pregnant women in Xiamen
Wei ZHUO ; Xinjing MA ; Chunlei ZHU ; Taichun CHEN ; Chunying LI ; Jianjun NIU ; Yue HUANG ; Shoujie HUANG ; Zizheng ZHENG ; Ting WU
Chinese Journal of Experimental and Clinical Virology 2017;31(4):315-319
Objective:
To investigate the seroprevalence and epidemiological characteristics of hepatitis E virus (HEV) infection in pregnant women in Xiamen.
Methods:
Sera samples of 910 pregnant women were collected from September 2014 to June 2015 in Xiamen Huli District Maternity and Child Care Hospital. Those who intended to give birth in target hospital were included in a subgroup which was asked to collect the second serum sample. All samples were tested for anti-HEV IgM and IgG antibody by enzyme linked immunosorbent assay (ELISA). HEV RNA was tested by reverse transcription-polymerase chain reaction (RT-PCR) for the positive samples of anti-HEV IgM antibody, meanwhile, the quantitative detections for anti-HEV IgG were conducted in specimens positive for anti-HEV IgG.
Results:
Of the 910 pregnant women, 8 (0.88%, 95%