Objective To discuss the clinical efficacy and nursing points of Curosurf combined with nasal continuous positive airway pressure (NCPAP) on children with neonatal respiratory failure.Methods Children with neonatal respiratory failure were randomly divided into the control group and the treatment group. Children in control group were treated with NCPAP and in treatment group were given Curosurf combined with NCPAP. The blood gas indexes and clinical efficacy were recorded and analyzed before and after treatment.Results The total effective rate in treatment group (88.89%) was significantly higher than that in control group (77.78%) after treatment for 48 hours ( <0.05) . Compared with children in control group, the blood gas indexes of children in treatment group were significantly higher after treatment ( <0.05) . Conclusion The methods of Curosurf combined with NCPAP and careful nursing can significantly improve clinical efficacy in the treatment of neonatal respiratory failure.