AIM:To observe the effects of high temperature on voltage - dependence of delayed rectifier K+ channel (Ik) in hypothalamus neurons. METHODS: The date recording from cell - attached patches of patch - clamp technique. RESULTS: With temperature raising, shift of voltage dependence may be mediated at different degree, while higher temperature might weaken and depressed. CONCLUSION: Shift of voltage dependence likely contribut- ed to the body fever and heatstroke.

Objective To investigate the effect of swallowing water test in the occurrence of aspiration pneumonia in patients with cerebral infarction. Methods One hundred and twenty?seven cases patients with cerebrovascular disease were randomly divided into two groups:swallow water group and control group,who were guided food program according to the result of swallow water test or experience. The number of two groups to use nasal feeding and the number of cases of the two groups occurred aspiration pneumonia in 3, 6 months were observed. Results The nasal feeding rate of swallow water group was higher than that of control group( 27. 6%( 21/76) vs. 11. 8%( 6/51) ,χ2=4. 590,P=0. 032) . After 3,6 months,the incidence of aspiration pneumonia of control group were higher than that of swallow water group(17. 6%(9/51) vs. 1. 3%(1/76),19. 6%(10/51) vs. 3. 9%(3/76),χ2=9. 080,6. 530,P<0. 05). Conclusion Water?swallowing test is a simple and practical method for assessment risk of aspiration pneumonia of patients with cerebral infarction,which is more effectively to reduce the risk of aspiration pneumonia than the empiric selection method of nasal feeding.

Objective To study the expressions of P53,vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in astrocytomas and their relationships with prognosis of these patients.Methods Immunohistochemical SP method was employed to detect the P53,VEGF and PCNA expression in 126 cases of human brain astrocytomas of different grades,collected in our hospital from May 2002 to May 2010; their correlations and their significance in the prognosis in these patients were analyzed.Results P53,VEGF,and PCNA expressed differently in astrocytomas of different grades,enjoying a positive relation with grades (P＜0.05); positive correlations of between P53 expression and both VEGF and PCNA expressions (r=0.608,P=0.000; r=0.432,P=0.001).In patients with the same grade of astrocytoma,those having positive P53 expression enjoyed poorer prognosis and lower survival rate with significant difference (P＜0.05); while VEGF and PCNA expressions had no correlation with the progonosis.Conclusion The expressions of PCNA,VEGF and P53 are closely associated with grade of the astrocytomas,and only P53 expression is an indicator of poor prognosis.