Objective To investigate effects of rectal cancer to undergo total mesorectal excision (TME)or three space dissection(TSD)with pelvic autonomic nerve preservation(PANP).Methods TME or/ and TSD was applied in 247 Patients with advanced rectal cancer in which 185 cases (74.9 %) underwent PANP(Group P)including TME-PANP(Group Pro)139 cases and TSD-PANP(Group Ps)46 cases.The other 62 cases underwent none-PANP(Group P-)due to tumor invasion.Results There were no death cases for operation inall patients.Group Pm was better than Group Ps in the operation time and the difficulty of proce- dure(P0.05).Conclusion The procedure with TME to preserve pelvic autonomic nerves adapts to the majority of rectal cancer patients.TSD procedure is more complex than TME.Statistically,the survival differ- ence between Patients with TSD and with TME is no defective.The survival time is determined to the tumor's earlier diagnosis and therapy.

Yigong powder is one of the classic famous prescriptions published in the Catalogue of Ancient Classical Famous Pre-scriptions(the Second Batch of Pediatrics).Through systematically collating textual research and analyzing ancient literatures and clini-cal literatures on Yigong decoction,the key issues of prescription origin,composition,drug base,processing method,usage and dos-age,efficacy and indications of Yigong powder were summarized,providing literature data support for the development and clinical ap-plication of the classic pediatric prescription of Yigong powder.According to the analysis and research,Yigong powder comes from Qian Yi's Key to Diagnosis and Treatment of Children's Diseases and is consisted of ginseng,poria cocos,atractylodes,tangerine peel and licorice,with ginger and jujube being used as guiding medicine.The medicinal base follows the 2020 edition of Chinese Pharmaco-poeia.Ginseng,poria cocos,and orange peel are used as raw products,atractylodes is used as bran fried atractylodes,licorice is used as processed licorice.Children should be differentiated from adults in terms of drug dosage.The dosage for children is 1.4—1.7 g each for ginseng,poria cocos,atractylodes,tangerine peel and licorice,and the dosage for adults is 5.6 g—6.8 g each.The method of making and taking medicine is to file drugs down,take 300 mL water,add ginger and jujube and fry to 210 mL,take warm medicine before meals and adjust the frequency according to the actual situation.The ancient prescription was often used in children anorexia,diarrhea and other diseases.After the innovation of later generations of doctors,it is also used for digestive system diseases,recurrent respiratory tract infections in children,allergic rhinitis and so on.

Echinococcus granulosus is an important zoonotic parasite globally causing cystic echinococcosis (CE) in humans and animals. In this study, prevalence of CE and variation of cox1 gene sequence were analyzed with isolates E. granulosus collected from different areas in northern Xinjiang, China. The survey showed that 3.5% of sheep and 4.1% of cattle were infected with CE. Fragment of cox1 was amplified from all the positive sheep and cattle samples by PCR. In addition, 26 positive samples across the 4 areas were included. The isolates were all E. granulosus sensu stricto (s.s.) containing 15 haplotypes (Hap1-15), and clustered into 2 genotypes, G1 (90.1%, 91/101) and G3 (9.9%, 10/101). Hap1 was the most common haplotype (48.5%, 49/101). Hap9 were found in humans samples, indicating that sheep and cattle reservoir human CE. It is indicate that E. granulosus may impact on control of CE in livestock and humans in the region.
Animals ; Cattle ; China ; Cross-Sectional Studies ; Echinococcosis ; Echinococcus granulosus ; Echinococcus ; Genotype ; Haplotypes ; Humans ; Livestock ; Parasites ; Polymerase Chain Reaction ; Prevalence ; Sheep

The changes of endogenous metabolites in urine samples that come from pneumonia patients of 6 months to 6 years old children were analyzed by metabolomics methods based on gas chromatography and mass spectrometry (GC-MS).The aim of this study was to analyze and study the pathogenesis of endogenous metabolites in children with pneumonia and the pathogenesis of pneumonia susceptibility.The urine samples were collected and divided into normal children group (NC group,n=29),first infection with pneumonia group (FIP group,n=35),and repeated infection with pneumonia group (RIP group,n=31).The urine metabolic profile of pneumonia was obtained by GC-MS.Principal component analysis(PCA) and partial least squares-discriminant analysis (PLS-DA) were used to analyze the data.The results were analyzed by one-way analysis of variance and Fold change.Finally,there was significant difference between the normal group and the pneumonia group,the significant metabolites were serine,histidine,proline,norleucine,glutamine,stearic acid,valine,isoleucine with p value<0.05 and Fold change>5,and indole-3-acetic acid,creatine,ethanolamine,mannosylglycerol and fructose were significant between the two pneumonia groups with p value<0.05.The urinary metabolites demonstrated that amino acid metabolism and glucose metabolism were the main metabolic pathways and responsible for the susceptibility to pneumonia.

Objective:To analyze the collected data of adverse events （AEFI） of pneumonia vaccine in Shanghai from 2010 to 2020，， so as to provide the appropriate immunization strategy and popularization of science for pneumonia vaccine . Methods:the data of suspected adverse events were collected from National AEFI Surveillance System during 2010 to 2020， and the vaccination information of pneumonia vaccine was obtained from Shanghai Vaccination Information System. Descriptive epidemiological method was used to analysis. Results:The total 18 446 AEFI cases were reported in Shanghai from 2010 to 2020， and the incidence rate was 425.0/100 000 doses. The general reactions were reported as 18 003 cases （97.6%）， with 393 cases of abnormal reactions （2.0%）， 57 cases of coincidences （0.3%）， 2 cases of psychogenic reactions （<0.1%） and no vaccine quality accident or vaccination accident was reported. There was no significant difference in the incidence rate between male and female； The incidence rate of AEFI decreased with the age of the old. The incidence rate of 23 valent pneumococcal polysaccharide vaccine （PPV23） AEFI was 476.5/100 000 doses， which was significantly lower than that of other kinds of pneumonia vaccine. The first dose was also significantly higher than that of non-first dose. Conclusion:The various types of pneumonia vaccines being used in Shanghai have high safety.