Objective To investigate the relationship between IL-18 and apoptosis in patients with SLE by using testing the changes of IL-18 and soluble Fas/soluble Fas ligand in sera from the patients.Methods 58 patients with SLE were divided into three groups according to their SLEDAI score;sera from 58 patients,and 30 normal controls were tested for IL-18 and sFas/sFasL using ELISA assay.Results The level of IL-18 and sFas in sera from SLE patients was significantly higher than that of normal controls(P0 05).Besides,the increased level of IL-18 was correlated well with the increased level of sFas (?=0 496,P0 5).Conclusion The increased level of IL-18 may result in the elevation of serum sFas/sFasL in patients with SLE.They may play important roles in the pathogenesis of SLE.

Objective:To preliminarily verify the feasibility of applying a wearable teleconsultation device in the diagnosis of common skin diseases.Methods:Totally, 600 outpatients with skin diseases were prospectively enrolled from the Department of Dermatology from November 1 to December 31 2023, and both on-site and remote diagnoses were performed. In the face-to-face clinic, there was one resident physician A and one chief physician B, while there was one resident physician C and one chief physician D in the remote consultation clinic. Using the diagnostic results of physician B in the face-to-face clinic as a reference, diagnostic agreement rates of physicians A, C, and D were calculated separately. Additionally, diagnostic results were compared between physician A and physician C, as well as between physician A and physician D. Statistical analysis was carried out using McNemar's test and Kappa consistency analysis.Results:Among the 600 patients with skin diseases, there were 285 males (47.50%) and 315 females (52.50%), and their age was 38.75 ± 21.12 years. The most common skin diseases were dermatitis and eczema (138 cases, 23.00%), followed by viral skin diseases (79 cases, 13.17%), urticaria (53 cases, 8.83%), hair diseases (53 cases, 8.83%), skin tumors (46 cases, 7.67%), fungal skin diseases (38 cases, 6.33%), etc. Compared with the physician B, the physician A made consistent diagnoses in 477 cases (79.5%) and inconsistent diagnoses in 123 cases (20.5%), the physician C made consistent diagnoses in 465 cases (77.5%) and inconsistent diagnoses in 135 cases (22.5%), and the physician D made consistent diagnoses in 568 cases (94.6%) and inconsistent diagnoses in 32 cases (5.33%). There was no significant difference in the diagnostic accuracy between the physician A and physician C ( P = 0.430), with a Kappa value of 0.852, indicating very strong consistency. The diagnostic accuracy of the physician D was significantly higher than that of the physician A ( P = 0.001), with a Kappa value of 0.274, indicating weak consistency. Conclusion:Chief dermatologists can provide medical guidance to resident physicians through a wearable teleconsultation system.