OBJECTIVE: There are some people in population susceptible to acute mountain sickness. Therefore, it is important to analyse, assess and integrate certain research results to build prediction system and mathematics model in order to predict those susceptible people when army goes to tableland.DATA SOURCES: Computer was used to search databases such as Medline, PubMed and PML to find articles regarding prediction of people susceptible to acute mountain sickness from January 1970 to December 2002 with the search words "acute mountain sickness, susceptible population,prediction" . The language was limited to English. At the same time, Chinese Journal Full-text Database, Chinainfo and CBMdisc were searched to find articles from January 1970 to August 2004 by the Chinese language of "acute mountain sickness, susceptible population and prediction". The research targets are susceptible people to acute mountain sickness. At last,trace-back method was used to supplement some literature and monographs.DATA SELECTION: After systematically analyzed and concluded the literature information and screened researches without conducting experiment, full text of the rest literature was searched and used as selective criteria if it could be used as prediction indicator of susceptible people to acute mountain sickness.DATA EXTRACTION: Totally there were 19 prediction indicators generalized. After conducting systemic analysis, Delphi method and analytic hierarchy process(AHP) to the indicators, 13 were selected while the other 6 were excluded.DATA SYNTHESIS: The indicators were classified according to nervous-humoral regulation ability, oxygen capture ability of respiratory system,anti-anoxia ability of central nervous system, mental health and health service ability. Based on these, system analysis, Delphi method and AHP method were used to screen prediction indicators, establish indictor system, confirm the weighted indicators and weighted indicator system as well as standardize the prediction indicators.CONCLUSION: According to the principle of prediction model and model methods, weighted linear synthesis method was used to build the predictive mathematic model. The project of susceptible population prediction of acute mountain sickness in army when entering tableland urgently was proposed combining the health service ability of army.

Objective To discuss curative effects of the AO Less Invasive Stabilization System(LISS) in the treatment of complex fractures around the knee joint.Methods The internal fixation at distal femur or proximal tibia was performed in 15 cases of closed complex fractures at the metaphysic area near the knee joint by using the LISS(left-sided in 9 cases and right-sided in 6 cases) from April 2004 to June 2005. Results All the 15 cases were followed for 5~26 months(mean,13.2 months).The time to full weight bearing was 12~26 weeks,and the time to bone union under X-ray was 11~24 weeks.No delayed union or disunion was observed.There were 1 case of superficial infection and 2 cases of skin blister,all of which were cured with dressing changes.No deep infection,skin necrosis,or osteofascial compartment syndrome occurred.Functional evaluation according to the Johner-Wruhs system revealed "excellent" results in 11 cases,"good" results in 3,and "fair" in 1,the total satisfactory rate being 93.3%(14/15).Palpable shift and separation inside tibia had occurred in 1 case of tibial plateau fracture(type C3) 2 weeks after operation,and a steel bar was inserted to fix the tibial plateau in a second operation.Bone union was achieved in this case 20 weeks after operation,with "good" evaluation results.Genu varum(tibial plateau angle,82?) had occurred in 1 case of tibial plateau fracture(type C3) 8 weeks after operation,and bone union was noted 20 weeks after operation,with "fair" evaluation results.Conclusions The LISS is indicated for fractures at distal femur or proximal tibia,or osteoporotic fractures of distal femoral shaft.For type C3 complex tibial plateau fracture,fixation with a steel bar on the entocondyle should be employed,rather than relying on the LISS.

Objective: To study the function of Leshibao Capsule (Radix Ginseng, Rhizoma Atractylodis, Sea cucumber, etc.) on stomach and intestines. Methods: Gastrointestinal function was measured by small intestine driving test, gastric juice quantity, pepsin activity and gastric emptying time. Results: Leshibao Capsule could increase gastric juice, enhance pepsin activity. It could adjust function of gastrointestine in two ways that showed gastrointestinal movement fasted by neostigmine and inhibited gastrointestinal movement slowed by diphenoxylate and morphine hydrochloride. Conclusion: Leshibao Capsule can adjust gastrointestinal function and facilitate digestive function.

Objective To establish a novel method for the determination of betaine in serum by high performance liquid chromatography with UV detection.Methods Pre-column derivatization of serum was performed directly in acetonitrile without extraction with p-bromophenacyl bromide and 18-crown-6 ether as catalyst.The p-bromophenacyl ester derivatives were then separated by Supelcosil LC-SCX, using an was 0.8 ml/min and the effluent was monitored at 259 nm. Betaine was used for preparation of standard curve and quantification with external standards.Results The linearity of this method was 6.25-200.00 μmol/L,the regression was 0.999 8.The detection limit was 3.0 μmol/L.The within-day imprecision was 1.88%-3.79% ( average 3.24% ), the between-day imprecision was 3.14%-6.76% ( average 4.39% ), the recovery rates were 95.89%-102.86% (average 99.16% ).Conclusion This method is sensitive, rapid, accurate and suitable for the research and routine clinical practice.

Evaluation of medical assistance capability plays a significant role in improving medical assistance capability and accomplishing a diverse array of military tasks.Based on gray theory and fuzzy mathematics,we put forward a new evaluation model for disaster medical assistance capability,integrating the AHP,the gray cluster analysis and fuzzy evaluation.This model not only reflects the ambiguity of medical assistance capability evaluation but also makes full use of the information,which avoids the flaws caused by single method of fuzzy mathematics.It provides a new way to evaluate disaster medical assistance capability comprehensively and systematically.

Objective To investigate the expression levels of BDNF, trkB and ChAT mRNA and proteins in the brain of adult tree shrews ( Tupaia belangeri ) .Methods Quantitative real-time PCR was employed to detect the expression levels of BDNF, trkB and ChAT mRNA in the hippocampus, basal ganglia and frontal cortex of adult tree shrews.The expression levels of BDNF, trkB and ChAT proteins andβ-actin was used as internal standard.Results The expression level of BDNF mRNA was highest in the hippocampus of adult tree shrew, and there were significant differences between that in the hippocampus, and basal ganglia and frontal cortex (P<0.01).The expression level of trkB mRNA was higher in the frontal cortex than in the basal ganglia and hippocampus, showing a significant difference between them ( P<0.05).The expression level of BDNF protein was significantly higher in the basal ganglia than in the hippocampus or frontal cortex (P<0.01).There were no significant difference (P>0.05) in the expressions of trkB protein among the hippocampus, basal ganglia and frontal cortex of the adult tree shrews.There were no significant differences in expressions of ChAT mRNA and protein among the hippocampus, basal ganglia and frontal cortex in adult tree shrews ( P>0.05 ) . Conclusions The expression levels of ChAT mRNA were consistent with that of ChAT protein in the hippocampus, basal ganglia and frontal cortex of adult tree shrews, while the expression levels of BDNF and trkB mRNA were not consistent with their proteins, which might indicate that the transcriptional regulation pattern might be more complex.Tree shrew is a valuable animal model in the study of mechanism of BDNF/trkB gene expression.

Objective To discuss the influence of new weapons in the high-tech war on eye wounds in order to develop the new time-effect treatment strategy. Methods The data of wounds in recent wars were investigated, the causes of eye wounds in high-tech war were analyzed, and the new concept of time effect treatment strategy for eye wounds was proposed. Results The weapons in high-tech war have developed into mass destruction and precisely guided munitions. The main cause of eye wounds is the shrapnel and some new wounds will occur such as eye wounds caused by laser or chemical toxin, radiation cataract. Conclusion In the future high-tech war, the major type of eye-wounds may still be the explosion injury and some new types of eye wounds should be paid more attention. The time-effect treatment strategy should be implemented to meet the demand of improving eye wound therapy and promoting the development of ophthalmology.

Objective To analyze the effect of using standardized patient (SP) tutorial in the spe-cialized training of pancreatic surgery with WeChat platform. Methods 48 surgeons participating in resi-dent standardized training in Changhai Hospital (all for postgraduate education) were enrolled as teaching object. 48 surgeons were divided into two groups: SP group (n=24) receiving WeChat combined with SP tutorial which updates learning plan, learning contents, and clinical discussion by Wechat platform and performs practical teaching by SP method, control group (n=24) receiving traditional tutorial by using tradi-tional clinical teaching methods and video teaching followed by practical teaching. The theoretical exami-nation, questionnaires and expert assessment were used to evaluate the effect of the two teaching methods. Statistical analysis was performed using the SPSS 19.0. Continuous data were expressed as median±stan-dard deviation and compared using the Student's t-test. Categorical data were compared using the Pearson's chi-square test. Results The score of theoretical examination of the two groups showed no significant difference [(85.5±7.6) vs. (81.4±14.9), P=0.238]. The results of questionnaires and expert assessment in WeChat&SP group were significantly better than those in the control group (P<0.001) other than theoretical and analytical ability (P>0.05). Conclusion WeChat platform combined with standardized patient tutorial in the specialized training of pancreatic surgery is feasible and more effective than traditional tutorial to improve teaching effectiveness.

Objective To analyze the clinical value of 1. 5T dynamic enhanced MRI in the differential diagnosis of prostate cancer. Methods A total of 298 patients with prostate disease admitted to Zhejiang Quhua Hospital from January 2017 to December 2017 were enrolled. All subjects underwent MRI(including T2WI,DWI, DCE),and the results of all subjects were observed. The pathological biopsy was used as the gold standard for diagnosis. The possibility of prostate cancer was evaluated. Results Among the 298 patients with prostate disease,there were 136 cases of prostate cancer,including 84 cases of peripheral prostate cancer,the detection rates of T2WI,DWI and DCE were all 100. 00％,52 cases of central gland prostate cancer,the detection rates of T2WI,DWI and DCE were 100. 00％,98. 08％,and 98. 08％,respectively. Among 298 patients with prostate disease,there were 162 cases of pre-existing adenitis,including 64 cases of peripheral prostatitis. The detection rates of T2WI,DWI and DCE were 98. 44％,100. 00％,96. 88％,respectively,98 cases of central glandular gland inflammation,the detection rates of T2WI,DWI,DCE were 97. 96％,100. 00％,98. 98％,respectively. Conclusion 1. 5T dynamic enhanced MRI can correctly detect prostate diseases,especially prostate cancer.

Objective ToexploretheapplicationofVasoCT,astentimagingtechnique,instent-assisted coilaneurysmembolization.Methods Twentyconsecutivepatientswith23intracranialaneurysmswere treated with stent-assisted aneurysm embolization in the General Hospital of Armed Police Forces from December 2013 to November 2014 were enrolled. The patients performed VasoCT scan immediately after procedure. Then all the available images were used for stent-optimized reconstruction respectively. Under the XpertCT mode,the available images were observed with both volume imaging and maximum intensity projection. The available images were analyzed and they were divided into very clear,less clear,and not clearaccordingtothestentdevelopingclarity.Results Ofthe22aneurysmstreatedwithstent-assisted embolization,16 were occluded completely,6 were occluded partially. All the stents were expanded completely and were released to the expected locations;11 aneurysm stents developed clearly,9 developed less clearly,and 2didnotdevelopclearly.Conclusion VasoCTcanbeusedinthestent-assistedaneurysmembolization.It can clearly reveal the microscopic structure of the stents,location,relationship with the artery wall,and relationship between stents and coils. The clarity of stent development is associated with the diameters of the packed coils,and the stents are also affected by the metal artifacts projecting direction and the dense degree of the packing coils.