Objective To observe the effect of Risperdal combined with occupational therapy on chronic schizophrenia.Methods 30 patients with chronic schizophrenia,who treated by Risperdal with adequate dose and sufficient course but still had negative symptoms,received a 12-week occupational therapy training(the dosage of Risperdal not changed).The patients were assessed using Scale for the Assessment of Negative Symptom(SANS)and In-patient Rehabilitation Rating Scale(IPROS)before and after occupational therapy.Results After occupational therapy,patients' SANS scores decreased significantly(P<0.01),and social function improved significantly(P<0.05).Conclusion Risperdal combined with occupational therapy can further improve the negative symptoms of patients with chronic schizophrenia and promote their social function.

AIM: This experiment is to investigate the effects of LPS on the organization and localization of VE-cadherin and F-actin in cultured human umbilical endothelial cells.METHODS: The human umbilical vein endothelial cell lines ECV-304 were incubated with LPS at different concentrations for 30 min. VE-cadherin was detected by immunofluorescence with primary mAb of VE-cadherin and FITC-conjugated secondary antibody. F-actin was detected with fluorescence staining with rodamine-phalloidin. RESULTS: At high concentration, LPS could induce reorganization of VE-cadherin with the formation of serrata cellular border and enlargement of intercellular gaps, which were apparently different from that in normal conditions with the high fluorescence intensity at cell-cell junction. F-actin depolymerization could also be induced by LPS at high concentration with the formation of stress fiber and filopodia. CONCLUSION: LPS(300 ?g/L) could induce reorganization of VE-cadherin and F-actin in human umbilical vein endothelial cells.