From 1985 to 1987, thirty cases of lower limb deep venous insufficiency were examined with strain-gauge plethysmography. Doppler ultrasound examination were performed simutaneously in 28 cases and phlebography in 27 cases. Thirty normal lower limb served as controls. The methods for the detection of maximum venous outflow, maximum venous back flow and venous refilling time were introduced. The principles of these techniques were discussed

Three hundred cases of internal hemorrhoids hare been excised by hemorrhoide- ctomy with co laser in our hospital since July,1988The operation was performed under local anesthesia.After ligation of the hemo-rrhoid artery excision of internal hemorrhoid was carried out by co laser the stump of hemorrhoid was carbonized to promote vessel coagulation.postoperative pain was slight.Only 22 cases required narcotic analgesics. Bleeding was minimum except 2 cases with hypertension.Urinary retention developed in 2 cases.Thrombosis of external hemorrhoids developed in 3 cases.Wounds healed within 7 to 10 days.Fifty cases have been followed up for more than one year with no recurrence

Objective To determine the maximum venous outflow of the lower extremity deep veins in case of deep venous thrombosis (DVT). Method We use IMEX9000 multi-function vascular diagnosis instrument to examine 166 lower extremities of 100 controls the maximum venous outflow. The measurement was carried on in 46 diagnosed DVT cases for healthy and diseased limbs. Ascending venography was also performed. Three indicators were adopted including venous capacitance (VC) ,2 second venous outflow(VO) and maximum venous outflow ratio(MVOR, namely VO/VC).Result Normal MVOR is 1. 08?0. 18, irrespective of age and gender. MVOR drops significantly in diseased limb (0. 69? 0. 14),paralleling with the result of ascending venography. Conclusion MVOR has the explicit diagnosis value for lower extremity deep venous thrombosis. A MVOR

Objective To study the mechanism of acute lung injury secondary to isolated severe head injury.Methods Twenty-two male SD rats were randomly divided into normal group(NG,n=4),and trauma group(TG,n=18)which were sacrificed respectively on day 1,3,7.The pathomorphological changes were observed by light and electron microscope.The levels of tumor necrosis factor-alpha(TNF-?)and interleukin-8(IL-8)in bronchoalveolar lavage fluid(BALF)were investigated by radioassay(RIA).The level of soluble intercellular adhesion molecule-1(sICAM-1)in BALF was measured by enzyme linked immunosorbent assay(ELISA).Results Capillary congestion,inflammatory cell infiltration and thickening of alveolar septum were detected in TG from day 1 to 7 by light microscope.The histological score of lung on day 3 in TG was significantly higher than that on day 1 and 7.The ultramicroscopic structure of lung showed swelling of vascular endothelial cells,infiltration of polymorphonuclear neutrophil and monocyte,injury of pulmonary epithelial cells in TG from day 1 to 7.The levels of TNF-?,IL-8 and sICAM-1 in BALF in TG were significantly higher than that in NG and the peak values were on day 3.The histologic score in TG was positively correlated with the levels of TNF-?,IL-8 and sICAM-1 in BALF.Conclusion Isolated severe head injury could induce acute lung injury that reached the most severe degree on day 3.The elevation of such proinflammatory cytokines as TNF-?,IL-8 and sICAM-1 in BALF plays an important role in the development of excessive inflammatory response of lung injury secondary to isolated severe head injury.

Objective To assess the effects of treating varicose vein with endovenous laser treatment(EVLT). Methods 810nm wavelength diode laser machine was used to treat 170 patients with varicose veins of the legs. After treatment, leg bandage compression was used for 2 days, and then changed to elastic stockings for 6-8 weeks. Patients were examined with Doppler ultrasound at follow-up. Results Post-operative follow up(1-12 months) of EVLT in 170 patients indicated 100% rate of greater saphenous vein closure on Doppler ultrasound, and no significant complications. All of the symptoms, disappeared or were significantly improved. Conclusions The results of EVLT of varicose veins have been favorable. This minimally invasive technique appears to be safe, and results in very effective closure of great saphenous vein.

Objective To investigate the psychological condition of the rural residents with HIV/AIDS.Methods Totally 192 subjects with HIV/AIDS residing in countryside of Henan Province(China)were investigated with questionaire and Symptom Check list 90(SCL-90).Results SCL-90 total score,the number of positive items and the score of each factor for the 192 subjects with HIV/AIDS were higher than those of Chinese normal(P

Objective To investigate the effect of wire?reinforced epidural catheters on the success rate of epidural catheterization for labor analgesia. Methods A total of 200 nulliparous parturients who re?ceived labor analgesia voluntarily, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 20-45 yr, with body mass index<35 kg∕m2, were divided into 2 groups (n=100 each) using a random number table: common catheter group ( group Ⅰ) and reinforced catheter group ( group Ⅱ) . After suc?cessful epidural puncture, the corresponding catheter was inserted inⅠandⅡgroups. The development of difficult insertion, intravascular catheter insertion or paresthesia during insertion was defined as a failure of epidural catheterization. The occurrence of the failure of epidural catheterization was recorded. Results Compared with group Ⅰ, the failure rate of epidural catheterization was significantly decreased in groupⅡ( P<0.05) . Conclusion Wire?reinforced epidural catheters can raise the success rate of epidural catheter?ization for labor analgesia.

OBJECTIVE:To prepare Diphenidol hydrochloride double-layer osmotic pump tablets,and study its in vitro release characteristics. METHODS:Double-layer compressing technique and film coating technology were conducted to prepare Diphenidol hydrochloride double-layer osmotic pump tablets. The in vitro releases of it,Difenidol hydrochloride tablets in market,self-made Difenidol hydrochloride single-layer osmotic pump tablets were compared. RESULTS:The formulation was as follow as diphenidol hydrochloride 75 mg,sodium chloride 10 mg,low-molecular-weight polyoxyethylene 15 mg and right amounts of 5% PVP K30 ethanol solution. Booster layer was high-molecular-weight polyoxyethylene 60 mg,sodium chloride 20 mg,PVP K306 mg,right amounts of magnesium stearate. 12 h cumulative release(Q)of prepared double-layer osmotic pump tablets reached 80%,and the release was in line with zero-order kinetic equation. Q15 min of Difenidol hydrochloride tablets had reached 90%;Q12 h of Difenidol hy-drochloride single-layer osmotic pump tablets was only 51.14%. CONCLUSIONS:The prepared Difenidol hydrochloride dou-ble-layer osmotic pump tablets have sustained release effect,with more complete drug release within 12 h than single-layer one.

Objective: To prepare diphenidol hydrochloride push-pull osmotic pump tablets and in-vestigate the influence of differ-ent factors on in-vitro drug release. Methods: The cumulative release of different formulas was detected. Using the cumulative release and similarity factor f2as the evaluation criterion, single factor experiment was applied to screen the core formula and coating process. Results: The drug release behavior was affected by the content of PEO in the drug containing layer, the content of NaCl and the weight gain of the coating layer. After the formula was optimized, the NaCl content in the drug containing layer was 10mg, the PEO-N10 con-tent was 15mg. In the push layer, the content of PEO-WSR303 was 60 mg, that of NaCl was 20 mg. The optimized coating liquid for-mula contained 1. 25 g·L-1PEG4000 and the coating weight gain was 7% of the core. The optimized formula fitted a zero-order equa-tion within 2-12h with the drug release equation of Q=6. 308t-2. 5037(r=0. 995 8). Conclusion: The preparation technology of di-phenidol hydrochloride push-pull osmotic pump tablets is stable, and the in-vitro drug release fits zero-order model.

Pathological insulin resistance (IR) is closely related to gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in women with GDM. Increasing studies have investigated the efficacy of IR indices, such as quantitative insulin sensitivity index, homeostasis model assessment of insulin resistance, triglyceride-glucose index and sex hormone-binding globulin, in predicting GDM and related complications in recent years. This article reviews the research progress in the above topics.