Given the outbreak of accidents in which workers, engaged in the management and control of national forests, are stung by wasps, the Forestry Agency has decided to have them carry around and, when anaphylactic shock occurs after a sting, use Epipen, an automatic injector of American makes immediately.
In this paper, we report on the developments that have led to the use of Epipen, the clinical cases for which it was used, and its efficacy. The automatic syringe was used for 10 cases over a period of five years, and the lives of nine of them were saved thanks to its efficacy.
It is hoped that this syringe will be used not just by the Forestry Agency but in a broad range of pre-hospital care sectors.

The farmers accident compensation insurance system is on the verge of a crisis. With the ratio of revenue to expenditure being 100 to 131.5, it has become extremely difficult to indemnify the insured or their beneficiaries for bodily injury and death due to accidental means.
This reflects rapid progress in mechanization of farm work and aging of the farming population, which results in an alarming increase in the number of serious accidents. A check on a survey taken by the Ministry of Agriculture, Forestry and Fisheries in 1992 reveals that the number of accidents in which farmers were killed while at work amounts to 401 cases. Of this number, 256 cases, or 63.8%, involved persons of 60 years and above, indicating the dead and injured in agricultural accidents are increasing in number among elderly people.
In Kanagawa Prefecture, a total of 446 accidents involving farmers and agricultural machinery have occurred over the past eight years. The average number of days lost by injured persons in the agricultural accidents worked out at 39 days. The average occurrence rate of an agricultural accident per 1, 000 persons came to 14.4, nearly three times as high as the average 5.2 for the rest of industries. A look at the accident occurrence rate in 1993 per 1, 000 persons insured under the workmen's accident compensation insurance system also showed that it was 28.0 for agriculture, compared with 16.5 for construction industry and the average 13.8 for all industries. This clearly indicates that agriculture has been transformed into a type of industry “structurally” in great peril.
Such being the circumstances, it is urgent that bold measures should be taken to inprove the balance between expenditure and revenue in the workers accident compensation insurance that has to do with agriculture. Among the measures we would like to propose here:(1) to promote accident prevention measures and hold in check an outlay for compensation;(2) to increase the number of the insured and garner more premiums;(3) to increase basic premium rates (?);(4) to beef up the secretariat of JA (?); and (5) to establish a safety-first administrative management.

A 64-year-old man had a history of interstitial pneumonia and emphysema since 2000. He underwent video-assisted thoracic surgery (VATS) for lung carcinoma at another hospital on June 30, 2003. Because he suddenly suffered anterior chest pain with shock in September 11 2003, he came to our emergency room. His blood pressure showed 90mmHg, his consciousness level was drowsy and it changed to shock status. Cardiac tamponade was diagnosed by cardiac echography showing an echo-free space and pericardiocentesis was carried out for urgent management of acute tamponade. After the removal of pericardial effusion, his consciousness and blood pressure returned to a normal level. As pericardial blood effusion was continued without aortic dissection by CT, we performed an emergency operation. We set up an external cardiac bypass immediately and removed a massive hematoma weighing 422g, we colud then find the ruptured circumflex coronary artery with a small hole of pericardium penetrating the left pleural space and repaired that ruptured coronary artery during cardiac arrest. His postoperative course was uneventful, and he was discharged on October 6.

We performed extraanatomic bypass from the thoracic aorta to bifemoral arteries for 4 aortoiliac occlusive disease (AIOD) patients (including 2 dialysis patients) with severe calcification of abdominal aorta and 5 high aortic occlusion (HAO) patients between January 2001 and September 2006. The average age was 69 years old (range 46-80) including 6 men. Two HAO cases were in the acute phase, one of whom had accompanying lower limb paralysis. Two of the AIOD cases showed small aorta syndrome. The mean operation time was 145min and intra- or postoperative bleeding was very low. We lost one peritoneal dialysis patient with AIOD in the 2nd postoperative week, due to infection from the CAPD tube. Perigraft seroma which is a complication of the artificial blood vessel itself was seen in 3 patients but graft patency was 100 percent at 2 years postoperatively.

A total of 194 cases of liver cirrhosis, which had been treated in our hospital during the past 5 years, were calssified by the causes into the following four groups:(I) hepatitis B virus, (II) alcoholic, (III) special origins, and (IV) reasons unknown. They each accounted for 23.2%, 35.6%, 1.5% and 39.7%, of the total.
Their clinical features and prognosis were examined. To be noted is the finding that many patients in group IV had had blood transfusions. This suggests that non A non B hepatitis viruses might be involved in the occurrence of the liver disease. On the whole, the five-year survival rate was 45.6%. There was not any significant difference among the four groups. However, prognoses were poor in groups II, I and IV, in that order.
As regards the cause of death, rupture of esophageal varice and hepatic failure showed a gradual decline, but complications of hepatocellular carcinomas sharply increased. Especially, in group I, this mortality was as high as 31.1%.

To demonstrate delayed neuro-toxicity of organophosphate, we administered 13 types of organophosphorous pesticide to hens. Initially, a screening test was performed with nine varieties of the chemical product. Later, four types were given to the fowls. Those hens dosed with S-Seven and Surecide developed ataxia and other neurophatic symptoms in the lower limbs.
After 50 days of observation, all the hens were killed and anatomized. Phathohistological examination revealed various changes in the hens that developed neuropathic symptoms: atrophy, diminution and disappearance of nerve cells in the anterior horn of the spinal cord ; edematous changes in the myelin; swelling of the neuroglia ; atrophy and vaculolar degeneration of liver cells; and necrobiosis of nepaticlobures.
It was found that these changes are closely related with the development of ataxia and doses of the chemical.
It was also found that the pathotistological changes occurred to a less extent in those hens which did not develop toxicoses.

We investigated the content of NO₃-N in the well water of the eastern, middle and nothern districts of Nagano Prefecture. The NO₃-N content seasonally changes and takes on the pattern of a high in summer and a low in winter.
Rain is considered to dilute the contaminated well water, but it lets NO₃-N flow from the soil into the.well water, when the rain is poured by a typhoon. As a result, a high content of NO₃-N is measured in the well water.
The water sample of 25 out of 85 wells in Matsukawa Town exceeded the tolerance level of NO₃-N (10 ppm, but 44.3 ppm in terms of NO₃^-).
By crop area, the amount of NO₃-N was highest in the fruitgrowing area, which was followed in order of the vegetable-growing area, the flower-growing and the rice planting area.
We consider that the contamination of well water is caused both by chemical fertilizers and the less absorbility of the soil.

There are no signs of a drop in the number of deaths in accidents while at farmwork, hovering around 400 a year. Furthermore, the fact remains that accurate data about those farm accidents are not fully grasped.This reality gave birth to a Special Study Team on the Prevention of Farmwork Accidents in the Japanese Association of Rural Medicine.To cast light on the actuality of farm work accidents, questionnaires on accidents caused by farm machinery and instruments were sent to three medical institutions affiliated with the Association from October 2002 to March 2004. As a result, clinical data were collected on 141 clinical cases. Moreover, studies were performed on five cases in which rescue squads were dispatched to give aid to the injured.The data thus collected on the clinical cases revealed that grass cutters, harvesters, riding and push-on-foot types of tractors, and straw cutters were responsible for many accidents. Some individuals were involved in the accidents as operators of grass cutters were unaware of their existence nearby because of noise from the machines, some dragged in by the harvesters or straw cutters, and some pinned under the tractors.Case studies on death-induced accidents suggested the indispensability of fitting a safety frame and a seat belt to the tractor and installing a cabin on the speed sprayer.For the prevention of accidents by farm machinery, it is important to hold lecture meetings more frequently both on the basic method of their use and on first aid.
Prevention ; Clinical ; Accidents ; Industrial machine, NOS ; Research

Paraquat is one the most popular herbicides in agriculture in Japan. To study the chronic toxicological effects of paraquat on animals, rats were fed a paraquat-containing diet for 1 year and 2 months (1, 5, 25mg/kg of body weight/day). Paraquat administration induced serious histochemical changes in various organs, such as the lung, heart, kidney and liver in rast. Pulmonary fibrosis occurred in the group of rats given 1mg paraquat/kg of body weight/day in diet.
The alkaline phosphatase activity and creatinine content in the blood serum significantly increased. The concentrations of cholesterol, triglyceride and phospholipid in the serum decreased significantly.
A significant increase of lipid peroxidation was observed in the brain, kidney and liver.

Two hundred and thirty adipose tissues were collected from inpatients, who had undergone an operation and an autopsy in the Saku Central Hospital from 1980 to 1982. Organochlorine pesticides were extracted from the adipose tissues and determined by gas-liquid chromatography with an electron-capture detector.
The mean value was 1, 429 ppm for total BHC among males, and 1.665 ppm among females, 4.893 ppm and 3.791 ppm for total DDT, 1.082 ppm and 0.782 ppm for PCB, respectively. Regression analysis between the total BHC residue and the ages of patients indicated a positive correlation for both sexs. As for the relation between the rate of obesity and the residues, low rates of obesity (-10%--19%) were most significantly correlated with high values of total BHC, total DDT and PCB.
We also discussed relations between cancerous diseases and the residues.