Kippikijitsushokyoto is described in the great classical text, the Kinkiyoryaku (Jinguiyaolue) as the formulation for treating kyohi. We report seven cases of cough successfully treated with kippikijitsushokyoto. Almost all of these cases had similar symptoms, i.e., an itchy feeling in the throat, sputum that could not be expectorated easily, no feeling of dry throat, and skin findings of lighter complexion and increased moisture. Our clinical experience suggests that kippikijitsushokyoto is an effective treatment for cough accompanied by an itchy feeling in the throat.

The administration of Bukuryo-shigyaku-to has been effective in five cases of chronic headache. All five patients visited our department because of unsatisfactory results using Western medicine. They suffered from severe migraines with restlessness, and they were treated effectively with Bukuryo-shigyaku-to. In four of all cases (cases 1-4), symptoms and signs related to coldness were obvious, and especially cases 1 and 3 complained about undesirable coldness on their backs. It is suggested that Bukuryo-shigyaku-to can be useful against severe migraine with restlessness caused by exposure to strong coldness. Case 5 was initially thought to have a status of heat and excess, but the effect of Bukuryo-shigyaku-to revealed the existence of cold and deficiency. Case 5 emphasizes the importance of being aware of the possibility of hidden coldness and deficiency, and that Bukuryo-shigyaku-to can be useful in such a case.

We treated one rheumatoid arthritis (RA) patient with Toki-shakuyaku-san-ka-bushi. A 51-year-old woman was diagnosed as RA in another hospital and was treated with salazosulfapyridine (SASP) and methotrexate (MTX). She was living a restricted daily life while taking MTX. She had to lie down for almost 48 hours after taking MTX once a week because of general fatigue. She was also suffering from depression. After the administration of Toki-shakuyaku-san-ka-bushi, her malaise after taking MTX and her depressive-mood disappeared. Her quality of life improved measurably.

We successfully treated two chronic hepatitis B patients with Hochuekkito-go-Keishibukuryogan. Case 1 was a 27-year-old male diagnosed with chronic hepatitis B in 1998, who had received interferon (IFN) therapy. Liver function tests did not improve with this therapy. He visited the department of Japanese Oriental Medicine at Yukiguni-Yamato Hospital, complaining of fatigue, on **********. We initiated treatment with Hochuekkito-go-Keishibukuryogan. At two months of treatment, marked improvement in liver function tests was noted, with normalization of ALT, seroconversion (SC) and negative HBV-DNA. Case 2 was a 26-year-old male diagnosed with chronic hepatitis B in 2001 who had received IFN therapy. Seven months after termination of this therapy, on **********, he visited our department for a flare-up of hepatitis. Treatment with Hochuekkito-go-Keishibukuryogan was begun. Almost immediately, marked improvements were observed in the form of ALT and SC normalizations, and only slightly positive HBV-DNA.