1.Hochuekkito Efficacy in Late-Onset Hypogonadism (LOH) Patients
Tomoka KUMAMOTO ; Shinichi HISASUE ; Mitsuko YASUDA ; Hisamitsu IDE ; Toshiyuki CHINA ; Masahiro INOUE ; Keisuke SAITO ; Shuji ISOTANI ; Raizo YAMAGUCHI ; Satoru MUTO ; Shigeo HORIE
Kampo Medicine 2013;64(3):160-165
The purpose of this study is to evaluate the efficacy of hochuekkito for late-onset hypogonadism (LOH) patients. We administered hochuekkito 7.5 g/day for 8 weeks to 47 patients with LOH whose AMS scale was more than 27. We assessed the patients' symptom change with the AMS, SHIM, SDS, BDI, and SF-36. We measured their endocrine profiles and levels of their cytokines. At the end of study, 31 of 47 patients were evaluable. No significant difference in subjective symptoms was seen with any questionnaire after 8 weeks hochuekkito administration. However, hochuekkito significantly increased free testosterone and decreased ACTH/cortisol levels. Thus we believe hochuekkito is beneficial for the treatment of LOH.
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