The purpose of this study was to examine the effect of fructose ingestion on maximal exercise performance capacity following prolonged steady-state exercise compared with glucose or placebo ingestion, in 7 male college students (age 23.3±0.7 yr, height 171.3±1.9 cm, weight 68.4±1.4 kg, Vo2max 3.5±0.2 L/min, mean ± SEM) . The subjects cycled constantly on an ergometer at 59± 2 % Vo2max for 100 min divided in the middle by a 5-min rest, and then performed 10 min of all-out self-paced cycling. They ingested either 8 % fructose solution (F), 8 % glucose solution (G) or artifi-cially sweetened placebo (P) before and during exercise (at 20, 40, 65, 85 mm) . Before exercise and at 50 and 100 min of exercise and 5 min after the performance ride, blood samples were collected for determination of the concentrations of blood lactate, serum glucose and serum FFA. In the G trial, the serum FFA level was significantly lower than in the P and F trials at any of the time points dur-ing and after exercise (vs. P ; p<0.01, vs. F ; p<0.05) . However, glucose ingestion maintained serum glucose at a significantly higher level during and after exercise than placebo ingestion (p< 0.01) and improved the total work output in the 10-min performance ride (G vs. P ; 135± 8 KJ vs. 128± 8 KJ, p<0.05) . Although in the F trial, the serum FFA level was elevated during exercise compared to that in the G trial and the serum glucose level was significantly higher than in the P trial (vs. P ; p<0.01), the blood lactate level after exercise was lower than in the G trial and total work output was similar to that in the P trial (123± 8 KJ, vs. G ; p<0.01) . These results indicate that fructose ingestion before and during exercise cannot improve the ability to perform high-intensity exercise late in prolonged exercise despite maintaining the serum glucose level.

Butyrate is a short-chain fatty acid produced during fermentation of fibers and other substrates in the gastrointestinal tract. A recent study has shown that elevation of butyrate availability by dietary supplementation exerts favorable effects on glucose metabolism. However, it remains unclear whether butyrate intake affects insulin-sensitive glucose transporter (GLUT-4) protein content in skeletal muscle, which has been shown to be closely related to muscle glucose transport capacity and whole-body insulin sensitivity. The purpose of this study was therefore to examine the effects of dietary intake of butyrate on muscle GLUT-4 protein content and whole-body insulin sensitivity in rats. Seven-week-old male Sprague-Dawley rats were placed on a sodium butyrate diet (SB) or standard chow diet (CON) for 2 wks. Sodium butyrate was incorporated into the standard chow diet at 5 % wt/wt. After the 2-wk dietary intervention, insulin tolerance test (ITT) was performed to evaluate whole-body insulin sensitivity. GLUT-4 protein contents in soleus and epitrochlearis muscles were determined by western blot analysis. There were no significant differences in body weight, food intake and intra-abdominal fat weight between the SB and CON groups. GLUT-4 protein contents in soleus and epitrochlearis muscle were significantly lower in the SB than CON group. The SB group had less reduction in glycemia than did the CON group during ITT. These results suggest that dietary intake of sodium butyrate may decrease muscle GLUT-4 protein content and impair whole-body insulin sensitivity in rats.

Epithelial borderline ovarian tumors (BOT) are distinctive from benign tumors and carcinoma. They occur in younger women more often than carcinoma, and there is some difficulty making correct diagnosis of BOT. Two subtypes of BOT, serous and mucinous borderline tumor have different characteristics and very different clinical behavior. Serous borderline tumor (SBT) with micropapillary pattern shows more incidence of extra ovarian disease and often coexists with invasive implant. SBT with micropapillary pattern in advanced stage has showed a worse prognosis than typical SBT. Huge mucinous borderline tumors have histologic heterogeneity, and the accuracy of frozen section diagnosis is relatively low. Extensive sampling is required to reach a correct pathological diagnosis. Mucinous adenoma (intestinal type) also runs the risk of recurrence after cystectomy, or intraoperative rupture of cyst. Laparoscopic procedure for BOT has not increased the risk of recurrence. Fertility preserving procedures are generally accepted, except in advanced stage SBT with invasive implants. Only cystectomy shows a significant risk of recurrence. Re-staging surgery and full staging surgery is not necessary for all BOT. We should not attempt to treat them uniformly, by the single diagnosis of "borderline tumor". It depends on histologic type. Close communication with the pathologist is necessary to gain more detail and ask more pathological samples in order to make the optimal treatment strategy for each individual patients.
Adenoma ; Cystectomy ; Diagnosis* ; Female ; Fertility ; Frozen Sections ; Humans ; Incidence ; Laparoscopy ; Mucins ; Ovarian Diseases ; Population Characteristics ; Prognosis ; Recurrence ; Rupture

Epithelial borderline ovarian tumors (BOT) are distinctive from benign tumors and carcinoma. They occur in younger women more often than carcinoma, and there is some difficulty making correct diagnosis of BOT. Two subtypes of BOT, serous and mucinous borderline tumor have different characteristics and very different clinical behavior. Serous borderline tumor (SBT) with micropapillary pattern shows more incidence of extra ovarian disease and often coexists with invasive implant. SBT with micropapillary pattern in advanced stage has showed a worse prognosis than typical SBT. Huge mucinous borderline tumors have histologic heterogeneity, and the accuracy of frozen section diagnosis is relatively low. Extensive sampling is required to reach a correct pathological diagnosis. Mucinous adenoma (intestinal type) also runs the risk of recurrence after cystectomy, or intraoperative rupture of cyst. Laparoscopic procedure for BOT has not increased the risk of recurrence. Fertility preserving procedures are generally accepted, except in advanced stage SBT with invasive implants. Only cystectomy shows a significant risk of recurrence. Re-staging surgery and full staging surgery is not necessary for all BOT. We should not attempt to treat them uniformly, by the single diagnosis of "borderline tumor". It depends on histologic type. Close communication with the pathologist is necessary to gain more detail and ask more pathological samples in order to make the optimal treatment strategy for each individual patients.
Adenoma ; Cystectomy ; Diagnosis* ; Female ; Fertility ; Frozen Sections ; Humans ; Incidence ; Laparoscopy ; Mucins ; Ovarian Diseases ; Population Characteristics ; Prognosis ; Recurrence ; Rupture

As regards obesity screening tests, it's a widly known fact that there are many problems in the existing notation of various body indices.
Moreover, in regards to the determination of skin-fold thickness, measurments must be taken at two or three places, and this, plus the fact that a certain amount of expertise is necessary, represent a shortcoming.
Using abdominal girth, which can be relatively easily measured, together with the chest girth measurment, the author examined a method for assessing obesity.
Various body indices were computed from height, weight, chest measurement, abdominal girth, etc. and the correlation between their value and skin fold thickness and average skin fold thickness was determined.
As a result of this, abdominal girth measurement and evaluation may be used in obesity screen tests in the following way.
1. Method for measuring abdominal girth.
[1] Have the patient assume normal posture.
[2] Girth is measured (in centimeters) around the area mid way above the navel while the patient resting expiratory state with arms hanging limp and shoulders relaxed.
2. Method for computing obesity index.
obesity index=height (in cm) ×10/abdominal girth (in cm)
The subject of the above research is extreamly limited in respect to age range. Therefore, the authors would like to examine further to see if this method is applicable to all age renges.

Objective: Our previous study reported many technical alarms in the dispensing inspection support system due to setting or operation errors, but not due to dispensing errors, and that countermeasures reduce technical alarms. In this study, we investigated the long-term effects of the countermeasures.Methods: The log data of the inspection results were extracted from the dispensing inspection support system and divided into image inspection and weight inspection data. The details and frequency of technical alarms before (April-June 2019), after (April-June 2020), and one year after (April-June 2021) the countermeasures were compared by chi-square test.Results: The frequency of technical alarms in image inspection was 13.7, 11.3, and 9.1% in 2019, 2020, and 2021, respectively (p< 0.01). However, the frequency of technical alarms in weight inspection was 3.0, 3.0, and 1.6% in 2019, 2020, and 2021,respectively (p< 0.01). The ratio of technical alarms to all alarms was 98.2% for image inspections and 91.2% for weight inspections in 2021.Conclusion: The frequency of technical alarms was reduced by the countermeasures. However, the ratio of technical alarms to all alarms is still high, and further improvements are needed to prevent the loss of reliability due to technical alarms.