OBJECTIVE:To observe the efficacy of the reduced glutathione against hepatic lesion induced by antituberculotic agents.METHODS:A total of 226 patients with pulmonary tuberculosis undergoing short- course chemotherapy were randomly assigned to receive antituberculotic agents plus reduced glutathione throughout the course(treatment group,n = 114 cases) or to receive Inosine plus Glucurolactone(control group,n = 112).The patients were followed for 3～6 months with the incidence of hepatic lesion compared between the two groups.RESULTS:There were significant differences between the treatment group and the control group in the incidence of hepatic lesion,6 cases(5.3%) in treatment group vs.29 cases (25.9%) in the control group(P

Object To study the growth speed and dynamic spore production of CY-8202, which is an asexual strain of entomopathogenic fungi isloated from Cordyceps sinensis (Berk.) Sacc., to explore the method of artificial culture of CY-8208 strain, to assay its antibiotic activity and spectrem and to provide the experimental basis for studies of its active components. Methods Variations in colony diameter of the cordyceps hypha cultured on the fungi media were measured. The spore-count was used to determine the dynamic colony spore outputs of the hypha on several fungi media and water agar. The agar-piece method was used to test its antibiotic activity.Results There were linear relationships between the colony extensions and the culture times on common fungi media such as PDA medium, etc.. The amounts of spore produced by the single colony of the fungi were more than 10 7 and gradually increased, but the rates of increase tended to be gentle after 200 h. Antimicrobial tests against 22 microbial strains showed strong inhibition of gram positve bacteria including Bacillus subtilis, Micrococcus tetragenus and Staphylococcus albus, and to gram negative bacteria, including Proteus vulgaris, Salmonella typhi, Aerobacter aerogenes and Salmonella sp., as well as weak inhibition of three mold strains and one actinomycetes strain, but no inhibition was observed in four yeast tested.Conclusion The growth activity and the spore-production ability of Cordyceps hypha are two important factors to infect validly its insect-host. For the growth activity, its strong penetration seems more important than its fast growth. The ability to product numerous spores of Cordyceps hypha may be an important mark of its strong infectivity to insect-host. The antimicrobial tests show that CY-8202 may secrete some metabolites which have a more broad-spectrum antibacterial activity than cordycepin isolated initially from Cordyceps militaris.

A non spore fungal strain designated as CR 9512 was isolated from a species of Cordyceps , found in Northern Guangdong of China The growth characteristics and the morphology of the organism were studied It was initially identified as Rhizoctonia sp ,Agonomycetales Its antimicrobial tests, against 26 strains of Gram positive and Gram negative bacteria, actinomycetes, filamentous fungi and yeast, showed strong inhibition to some yeast of Rhodotorula, Saccharomyces, Pichia and Cryptococcus , and weak inhibition to yeast of Candida The speciality on a limited spectrum anti yeast of the organism will show an enormous value for researches and applications

OBJECTIVE: The pathogenesis of depression is not fully understood yet, but studies have suggested higher circulating C reactive protein (CRP) level might relate to depression occurrence. However, due to high variability of patients’ individual condition, the results to date are inconsistent. Considering CRP single-nucleotide polymorphisms (SNPs) could also regulate plasma CRP levels, in the present study, we hypothesized that inherited CRP allelic variations may co-vary with depressive symptomatology. METHODS: We recruited 60 depression patients with family depression history and 60 healthy control volunteers into this project. We detected circulation CRP level as well as genome CRP SNPs from participants of this project. RESULTS: We have found a significantly higher circulating CRP level in patients with a positive family history. Furthermore, we also identified some certain inherited CRP SNPs (A allele in rs1417938 and C allele in rs1205) could up regulate serum CRP level and distributed more in depression patients with family history. CONCLUSION: Our finding may raise new evidence that genetically increased serum CRP level through SNPs variation is likely to induce family inherited depression.
Alleles ; C-Reactive Protein* ; Depression* ; Genome ; Humans ; Plasma ; Polymorphism, Single Nucleotide ; Volunteers