Purpose: To discuss the feasibility and effect of reserving fertility treatments for young patients with ovarian malignant tumors. Methods: Retrospective analysis of clinical data of 40 patients receiving conservative treatments. Results: Among the 40 cases, there were 25 cases of malignant ovarian germ cell tumors, 13 cases of epithelium carcinomas, 2 cases of sexual cord mesenchymal tumors. 34 patients have survived till now, among which there are 20 cases of malignant ovarian germ cell tumors, 12 cases of epithelium carcinomas, 2 cases of sexual cord mesenchymal tumors. 8 patients relapsed after the first operation, six of which had hysterectomy as second operation. Among the 32 surving patients who have preserved their uterus, 31 patients have normal menstruations. 11 patients married and 6 patients had successful pregnancies. Conclusions: We should try our best to preserve the fertility of young patients with ovarian malignant tumors.

Objective:To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with chronic schizophrenia.Methods:100 cases patients with chronic schizophrenia weree selected.They were divided into rTMS stimulation group and pseudo stimulation group according to the random number table method,and each group include 50 cases.The positive and Negative Syndrome Scale (PANSS) and the Treatment Emergent Symptom scale (TESS) were used to assess the clinical symptoms and side effects before and after the treatment;The Wisconsin Card Sorting Test (WCST) and Repeatable Neuropsychological State Measurement (RBANS) were used to assess the patients' cognitive function before and after treatment.Results:After treatment,the PANSS total score,the positive subscale score,the negative subscale score,the general psychopathological subscale score in the rTMS stimulation group were significantly reducing (P＜0.05),and significantly lower than those in the pseudo stimulation group (P＜0.05),but the TESS scores between the two groups did not differ significantly before and after treatment.The percentage of WCST in rTMS stimulation group was significantly higher than that in the pseudo stimulation group (P＜0.05),and the total time and wrong thinking time was shorter than that in the pseudo stimulation group (P＜0.05);The visual span and delayed memory performance of RBANS was significantly increased in the rTMS stimulation group (P＜0.05),and the visual span was significantly higher than that in the pseudo stimulus group (P＜0.05);There were 2 cases of patients with mild symptoms after the first treatment in RTMS stimulation group,all patients were without complaint followed up for 3 months.Conclusion:rTMS treatment on the part of the cognitive function of patients with chronic schizophrenia has a certain improvement effect,and higher security,it is worth further study.

Paridis Rhizoma， a traditional valuable Chinese herbal medicine， has the functions of clearing heat and removing toxin， relieving edema and pain， cooling liver and calming convulsion， which can be used to treat various diseases such as mumps， abscess， burn， bleeding， and tumor. It has been used in folk medicine for a long time and is the main raw material of various Chinese patent medicines such as Gongxuening Capsules and Yunnan Baiyao. Polyphyllin Ⅰ， an isospirostanol saponin and one of the main active components in Paridis Rhizoma， is distributed in the rhizome， pericarp， and leaves of Paris polyphylla. With high polarity， polyphyllin Ⅰ is mainly extracted by n-butanol extraction and macroporous adsorption resin chromatography， separated by silica gel column chromatography and preparative high performance liquid chromatography， and purified with the combination of methods. With anti-tumor， anti-inflammatory， antibacterial， and anti-virus effects， it is generally employed to treat liver cancer， lung cancer， gastric cancer and other cancers as well as arthritis， influenza， sore toxin， and bacterial infection. However， polyphyllin Ⅰ may cause stomach irritation， hemolysis， liver damage， kidney damage， heart damage， and other adverse reactions. Pharmacokinetic studies show that it has problems such as low bioavailability and poor intestinal absorption and permeability， which affect the clinical application of polyphyllin Ⅰ. This paper summarizes the research on the plant sources， extraction and separation methods， pharmacological effects， adverse reactions， and pharmacokinetics of polyphyllin Ⅰ in recent years， which is expected to provide a reference for the rational clinical application and other in-depth research work of polyphyllin Ⅰ.