Objective: To investigate prevalence of neurosis in a college of central China. Method:4465 college students were investigated by epidemiological method used in the national survey of 12 areas 10 years before. Result: The present prevalence of neurosis in students were 9.34%, higher than that of the national survey 10 years before (6.44%). In different diagnoses, the present prevalence of anxiety disorder was much higher. Male students had higher rate of neuroses than female, those in grade 3 or 4 had higher rate of neuroses than those in other grades. The most obvious invoke factor of neurosis was lovelorn. Conclusion: The prevalence of neurosis is higher than 10 years before.