Objective To investigate the difference of serum levels of adiponectin (APN)and its gene polymorphism +276 G/T 和-11377 C/G in Yao patients with CHD and Han CHD patients and Yao normal people in Guanxi district.Methods Yao CHD patients,Han CHD patients,Yao normal people and Han normal people,each of 100 cases were included in the study.The levels of serum adiponectin of all research object were detected by ELISA and APN+276 G/T and APN-11377 C/G genotyping were conducted by using PCR-RFLP.Results The levels of adiponectin in two groups of CHD patients were significantly lower than same race normal groups,the difference were statically significant (t=10.311,8.642,all P =0.000).The adiponectin levels of two CHD groups was not statically significant difference (t = 1.792,P =0.076);②The APN+276 G/T and APN-11377 C/G of four groups conform the Hardy-Weinberg population genetic equilibrium law (all P>0.05);③The main type of all groups APN+276 G/T was the wild type.The genotype frequencies of APN+276 G/T were no significant differences in between 4 groups (all P >0.05);④The CG and GG genotype frequency of APN-11377 C/G in two CHD groups were higher than same race normal group,the difference of Yao CHD group and Yao normal group was statically significant (χ2 =8.908,P =0.012;χ2 = 17.275,P =0.000),and the difference of Yao CHD group and Han CHD group were not statically significant (χ2 = 0.363,P = 0.834).Conclusion As with Han CHD patients,serum low APN level and APN-11377 C/G loci may be risk factors of Yao CHD patients.

Objective To construct a structural equation model to analyze the effect of various factors on the quality of life in stroke patients.Methods In this cross-sectional study,a total of 657 stroke patients from 2 ter-tiary A hospitals in Shanghai were enrolled as investigation subjects via convenience sampling methodology.General information questionnaire,Sense of Coherence Scale-13,Perceived Social Support Scale,Medical Coping Modes Questionnaire,National Institutes of Health Stroke Scale,Self-Esteem Scale and Stroke-Specific Quality of Life were utilized as the investigating tools;Mplus 7.4 was used to construct a structural equation model.Results The aver age score of quality of life in stroke patients was(178.30±30.30);neurological status,self-esteem were negatively cor-related with quality of life(P＜0.05);sense of coherence,social support,coping style were positively correlated with quality of life(P＜0.05);sense of coherence,taking a confrontational approach for coping,yielding and neurological status had a direct impact on quality of life(path coefficients were 0.471,0.169、0.135,-0.089,P＜0.05);social sup-port,self-esteem,sense of coherence and neurological status had an indirect impact on quality of life(path coefficients were 0.232,0.108,0.058,-0.058,P＜0.001).Conclusion The quality of life in stroke patients is influenced by multi-ple factors interactively,and sense of coherence is an important factor affecting the quality of life;adopting a confron-tational approach as coping styles,good social support and high self-esteem can improve the level of quality of life.