In order to analyze the influence of thyrotropin releasing hormone (TRH) on rehabilitation process of stroke Patients, the comparison of functional gain and length of hospital stay was made between eight patients treated with TRH (TRH group) and 11 age and sex matched ones without TRH (control group). Using Social Maturation Scale (Takenshiki, SMS) and Motor Age Test for trunk and lower extremities (MoA), the patients were assessed at the admission, 2 and 3 months after the admission and the discharge, respectively. TRH of 2mg was administered once a day by intravenous drip injection for 10 days between 2 and 3 months after the admission. The gain of SMS score between 2 and 3 months after the admission was larger in the TRH group than in the control group, especially that of interpersonal skills. The gain of MoA score was not different between the two groups. Compared to the control group (5.3 months), the length of hospital stay was significantly short in the TRH group (4.2 months). However, functional gain during inpatient-rehabilitation was not different between the two groups. It is assumed that TRH is effective to shorten the course of stroke rehabilitation.