Objective To study the difference of in vitro drug susceptibility test of biomembrane-producing Klebsiella pneumoni-ae to provide accurate drug reference for clinical treatment.Methods The drug susceptibility test was carried out in clinically isola-ted and screened16 strains of biomembrane-producing Klebsiella pneumoniae by K-B paper diffusion method ,and the results at 24 , 48 ,72 h were recorded.Then the strains were reproduced for several generations until not producing biofilm.Then the above opera-tions were taken again.Finally ,the results of twice drug susceptibility tests were performed the contrastive analysis.Results The mm number of inhibition zone of biomembrane-producing Klebsiella pneumoniae at 24 h had statistical difference compared with that at 48 ,72 h(P<0.05).Conclusion When the in vitro drug susceptibility test of biomembrane-producing Klebsiella pneumoniae is conducted by K-B paper diffusion method ,it is suitable to report the results after 48 h ,this has a certain reference value for pre-venting this bacterium.

Cerebral small vessel disease (CSVD) is a group of diseases that involve the structure and function of cerebral small perforator arteries, arterioles, venules and capillaries, thus causing a series of clinical symptoms and imaging manifestation. Although the pathogenesis of CSVD is not completely clear, more and more evidence indicates that the elevated level of serum inflammatory markers plays an important role in the occurrence and development of CSVD. This article reviews the correlation between serum inflammatory markers and CSVD.