With the improvement of endoscopic technology,an increasing number of early esophageal cancer is diagnosed by gastroscopy.Regardless of the size or submucous fibrosis of esophageal cancer,endoscopic submucosal dissection (ESD) allows en bloc resection and histologically complete resection of the tumor.ESD has been recognized as an optimal treatment modality for early esophageal carcinoma.Currently,short-term curative effects of early esophageal cancer after ESD have been proved satisfactory,but the long-term outcomes remain unclear.This paper reviews the research advances about the long-term outcomes of ESD,and focuses on the postoperative stenosis,the recurrence,metastasis and survival rates of patients,to provide treatment reference for clinicians.

Objective To observe the clinical efficacy of electroacupuncture plus puncturing the thirteen ghost points in treating diabetic gastroparesis.Method Sixty patients with diabetic gastroparesis were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture plus puncturing the thirteen ghost points, while the control group was by electroacupuncture alone. The clinical efficacies were then compared.Result The total effective rate was 93.3% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05). Conclusion Electroacupuncture plus puncturing the thirteen ghost points is an effective approach in treating diabetic gastroparesis.

Animals ; Child ; China ; Dairy Products ; Diet ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Nutritive Value

Cadherins that mediate the adhesion of the same type of cells by specific binding to calciumdependent adhesions of the same type with cadherins mainly consist of three subtypes including E-cadberin,P-cadherin and N-cadherin.In recent years,more and more studies have indicated that cadherins are closely related to triple-negative breast cancer(TNBC)and play an important role in prognosis and treatment of TNBC.

Objective To investigate the incidence and risk factors of hallucination in patients with Parkinson’s disease (PD) by using a questionnaire. Methods Ninety-one patients with PD from outpatient and inpatient departments of Neurology and 38 healthy subjects were recruited. Mini-mental state examination (MMSE), unified Parkinson's disease rating scale-Ⅲ(UPDRS-Ⅲ), Hoehn-Yahr, interleukin 6 (IL-6) and C-reactive protein (CRP) were examined in all PD. According to the PPQ-B scores, the PD patients were divided into two groups:the hallucination group (PPQ-B≥1) and non-hallucination group (PPQ-B=0). Logistic regression model was used to explore the risk factors. Results Twen?ty-nine of 91 patients had hallucination and the incidence was 32%. Age and the levels of IL-6 and CRP were signifi?cantly higher in hallucination group than in non-hallucination group. Meanwhile, the duration of illness and MMSE were significantly higher in hallucination group than in non-hallucination group. Logistic regression revealed that the age and duration of illness were independent risk factors of hallucination and the Odds Ratios (OR) were 1.09 (95% CI:1.04~1.32, P<0.05) and 1.43 (95%CI:1.21~1.87, P<0.05), respectively. The risk of hallucination increased by 51%and 59%for each doubling of IL-6 and CRP levels in PD patients and the ORs were 1.51 (95%CI:1.13~2.11, P<0.05) and 1.59 (95%CI:1.07~2.66, P<0.05), respectively. Conclusions Controlling the levels of serum IL-6 and CRP plays an impor?tant role in delay or prevention of the hallucination of PD patients.

Objective To observe the changes of chief chemical components(hypaconitine,ephedrine,pseudoephedrine,peoniflorin,glycyrrhetic acid) in the combinations of different-dose herbs of Wutou Decoction(WD). Methods Uniform design method was adopted to design the experiments,and HPLC was applied to determine the contents of chief chemical components of hypaconitine,ephedrine,pseudoephedrine,peoniflorin,glycyrrhetic acid. DPS V7.55 was used to carry out the nonlinear regression analysis of experimental data such as decocting rates of the chief chemical components. The mathematical model was established to analyze the experimental results. Finally,with the decocting rates of the chief chemical components as the optimizing indexes,the combination of optimal-dose herbs of WD was seeked. Results There existed an interaction between each herb of WD,and each herbs as well as the interaction between the herbs had a certain effects on the decocting rate of the chemical components. In particular,the interaction of prepared Radix Aconiti and prepared Radix Glycyrrhizae had obvious effects on the decocting rates of hypaconitine and glycyrrhetic acid. On the basis of the different optimization index,different combinations of optimal-dose herbs of WD can be obtained. Conclusion Through the method of nonlinear regression analysis,rich connotation of compatibility in Chinese herbal formula can be obtained.The optimization of optimal-dose herbs combination of the formula should be based on the pharmacological actions.

The amniotic membrane has been shown to have anti-inflammatory,anti-fibrotic,anti-angiogenic properties and ability to provide a substrate for the growth of corneal and conjunctival epithelial cells,and it is an ideal material for ocular surface reconstruction.The treating patten of corneal and ocular surface diseases has changed due to the widespread using of amniotic membrane transplantation,but there are a lot of problems in the application of amniotic memebrane in clinic,such as how to grasp indications and reduce the failure rate,how to apply individual skill for different patients with corneal disease,and how to observe postoperative complicationsm and reasonably use medicine after operation.This paper give some personal experience and opinion in orde to achieve better effects in treatment of corneal and ocular surface diseases using amniotic membrane transplantation.

Objective To evaluate the air bronchograpm in the differential diagnosis of peripheral solitary pulmonary nodule(3 cm or less) by computed tomography (CT). Methods The thin section CT images of air bronchogram in 190 eases with peripheral solitary pulmonary nodule confirmed by surgical resection and/or bronehoscopy and/or percutaneous needle biopsy and histopathology were analysed. Results The air bronchogram was seen in 52/100(52%) cases with peripheral lung cancers and in 29/50 cases (58%) with inflammatory pseudotumors on CT scans. Of lung cancers, there were adenocareinoma in 23/31 eases, squamous cell carcinoma in 14/41 cases, adenosquamous carcinom in 4/5 cases,small cell carcinoma in 7/14 cases and poorly differentiate carcinoma in 5/9 cases. The air bronchograms were not seen in 32 tuberculomas,5 hamartomas and 3 pulmonary cysts. Conclusion Air bronchogram can be seen in several pnlmonary nodules,it does not appear to be the characteristic of small peripheral carcinoma especially adenocarcinoma, and it alsc can not be helpful in distingushing malignant and benign pulmonary nodules.

Objective To study breathing characteristics of normal children of 6～7 years old when speaking in a normal manner.Methods RM 6240 physiological signal collection and processing system and Hx 100 respiratory transducer were used to collect the average peak expiratory pressure,inspiratory valley pressure,respiratory rate,respiratory depth from 160 normally speaking children.Results When speaking,the average peak expiratory pressure,inspiratory valley pressure,respiratory rate and respiratory depth of chest were all significantly increased (P<0.01);while that of abdomen was all reduced(P<0.05,P<0.01)except for respiratory rate(P<0.05)which was increased.In both respiratory conditions,all the data of abdomen were significantly larger than thaf of chest(P<0.01);all the data of boys were larger than that of girls(P<0.05,P<0.01).Conclusion When speaking,it involves thoraco-abdominal breathing,and the increase of chest activity will increase the volume of inhaled air.The increase of abdominal activity is for better control of respiratory airflow.Abdominal breathing plays a main role in normal speaking.Boys'respiratory muscles,respiratory organs are developed better than girls.

Approximately 20%-30% of the patients with acute ischemic stroke do not have an angiographically demonstrable arterial occlusion. This article reviews the possible explanations for the absence of angiographically documented occlusion, the risk and the occurrence rate of cerebral infarction, the prognosis, and the effectiveness as well as the safety of thrombolytic therapy.