Stromal cell-derived factor-1(SDF-1)is an early cell growth factor which belongs to a subfamily of chemokines.The CXCR4 is SDF-1 receptor.The SDF-1 interacting with CXCR4 plays important roles in physiological and pathological processes such as hematopiesis, stem cell homing,angiogenesis and leukemic cells infiltrating.To study the expression of CXCR4 in leukemia and the relationship between CXCR4 and leukemic cells infiltration can add indicators for leukemic MIC diagnosis of immunology indexes and have great significance to take molecule targeted therapy for preventing leukemia from infiltration or relapse as well.

0.05). The microhardness values of three test groups were higher than those of three control groups(P 0.05 ).Conclusion:Lanthanum chloride solution at 0.1 g/L has the same remineralization effect to 0.5 and 2.0 g/L in deciduous teeth with artificial enamel caries.

Objective:To compare effects of APF and APF-La(NO3)3 on enamel surface layer and to probe the mechanism of combined application of APF-La(NO3)3 on deciduous molars. Methods:9 caries-free second lower molars were selected and divided randomly into two groups: APF group (n=4) and APF-La(NO3)3 group (n=5). All teeth were cut into two parts, paralleled to axis of the teeth, along the line connecting mesial buccal and lingual cusps. Mesial parts were experimental group and distal parts were control group. Spot analysis of EPMA was performed to measure concentration of F or/and La in enamel surface layers, and compare changes of concentration of F in enamel surface layers treated with APF solution and changes of concentration of F and La treated with APF-La(NO3)3 solution. Results: ①Concentrations of F in enamel surface layers increased in APF experimental group. ②Concentrations of F and La increased in deciduous teeth enamel surface layers of APF-La(NO3)3 experimental group. ③ Increment of F in cusp of deciduous molar is the same as that of pit in APF experimental group. ④ Increment of F and La in cusp of deciduous molar was the same as that of pit in APF-La(NO3)3 experimental group. Conclusion:Compared with APF, treatment by APF-La(NO3)3 can increase the concentrations of both La and F in enamel surface layer while there is no difference of increment between cusp and pit in each group. The result can provide useful data for prevention of caries in children.

Child ; Child, Preschool ; China ; epidemiology ; Food Contamination ; Humans ; Infant ; Infant Formula ; chemistry ; Infant, Newborn ; Triazines ; poisoning ; Urinary Calculi ; chemically induced ; epidemiology

Objective To investigate alexithymia , personality characteristic and mental condition in patients with essential hypertension. Methods Fifty-one patients with essential hypertension were assessed using Eysenck personality questionnaire (EPQ), Toronto alexithymia scale (TAS-20) and the symptom checklist-90 (SCL-90). The results were compared with those of Chinese ordinary model. Results The E score of EPQ of the patients with essential hypertension was lower than that of the Chinese ordinary model, while the N, P and L scores was higher. The total score and the scores of all factors of SCL-90 were significantly higher than that of Chinese ordinary model. The total score of TAS-20 and score of factor 1, factor 2 were positively correlated with the scores of all factors of SCL-90, while factor 3 score had no significant correlation with SCL-90. The E score of EPQ was negatively correlated with the scores of all factors of SCL-90, while N and P score were positively correlated with them. Conclusion Patients with essential hypertension were inner personality, unstable psychological status and neuroticism showing alexithymia and obvious psychological symptoms.

BACKGROUND: Chitosan is commonly prepared using emulsion freeze-drying methods, which is complexly operated. OBJECTIVE: To introduce a simple methods for the preparation of chitosan and analyze its biological characteristic. DESIGN, TIME AND SETTING: Controlled observation experiments were carried out in the Central Laboratory, the Second Affiliated Hospital of Chinese Medical University (Shenyang, Liaoning, China) from April to December in 2007. MATERIALS: Ten Wistar rats of 8 weeks old and SPF grade were adopted. Chitosan powder in separated packs, with 99% purity and 99% deacetylation degree were the product of Shandong Jinan Ocean Bio-Product Co., Ltd. (China). METHODS: Acetic acid solution was added into chitosan to prepare 8% chitosan acetic acid hydrosol, which was then stayed for one day. Flowing the immersion into the hydrosol and immediate dislodgement, plastic tube was soaked in 1 mol/L sodium hydroxide for 3 minutes. Hydrosol out of the tube etiolated and coagulated into jells, the tube was removed when the jells were semi-dried. Subsequent to complete drying, chitosan tubes were prepared as an internal diameter of 5 mm, and were cut into many segmentations (length 2 mm). The prepared tubes were subcutaneously implanted into rat muscular tissues at right McBurney point, while rat left muscular tissues were only incised and sutured, taking as controls. MAIN OUTCOME MEASURES: Gross observation of chitosan tube, degradation percentage of chitosan tubes in rat muscular tissue, and tissue inflammation change around chitosan tube detected by hematoxylin-eosin stain. RESULTS: The surface of chitosan tube was smooth and the tenacity was good. Intramuscular implantation test showed that 50% and 90% chitosan tubes were absorbed by tissues in 4 weeks and 8 weeks postoperatively. Inflammatory reaction surrounding tubes was decreased gradually. CONCLUSION: It gives a new kind of way to prepare chitosan tube, with few materials, low cost, simple operation and short time. The prepared chitosan tubes approve the good histocompatibility and biological degradation.

Objective To assess the feasibility and safety between ALPPS and two-stage hepatectomy (TSH).Methods An electronic search was performed of the MEDLINE,EMBASE using subject heading to identify nearly three-years articles published that related to this topic.Pooled odds ratio was calculated for binary data and mean differences for continuous outcomes,using fixed-effects and random-effects models for meta-analysis.Results Four studies involving a total of 312 patients were used in the analysis.We found that ALPPS produced a higher increase rate of FLR than TSH (MD =24.78;95％CI:0.63 to 48.94;P =0.04).Comparing with TSH,ALPPS produced a shorter FLR growth time (MD =-26.55;95％ CI:-37.13 to -15.97,P ＜ 0.05).There was no statistical significance in overall mortality (OR =2.43;95 ％ CI:0.94 to 6.31;P =0.07),while ALPPS produced a more severe complication rate (≥ Ⅲ b) than TSH (OR =2.47;95 ％ CI:1.14 to 5.36;P =0.02).Conclusions It was better to make the FLR increasing to safe resection for ALPPS than TSH in a short period of time.There was no statistical significance in overall complication and mortality between ALPPS and TSH,but ALPPS produced more severe complication rate (≥ Ⅲb) than TSH.

Objective To investigate the antioxidant activity of Enteromorpha prolifera by ABTS radical scavenging assay in vitro and provide scientific basis for exploitation of Enteromorpha prolifera.Methods The antioxidant activities of extracts by different solvents from Enteromorpha prolifera and water extracts from different Enteromorpha prolifera samples were investigated by ABTS radical scavenging assay.Moreover,the antioxidant ability of the water extract from Enteromorpha prolifera was evaluated by using caffeic acid and ascorbic acid as positive control standards.Results The water extract from Enteromorpha prolifera provided the highest radical scavenging activity,and the antioxidant capability of 1mL of water extract from Enteromorpha prolifera was equivalent to 1mL of 2.55 10~(-3) mg?mL~(-1) caffeic acid or 1mL of 2.89?10~(-3)mg?mL~(-1) ascorbic acid.However,the extraction methods,dry sample or not and different kinds of Enteromorpha prolifera samples had certain influence on the antioxidant activity of water extract from Enteromorpha prolifera. Conclusion There are abundant antioxidant compounds present in the aqueous extract of Enteromorpha prolifera,and it can be exploited as latent oxidation inhibitor.

Micronutrients are closely associated with the progression of diabetes and its complications. Diabetic patients are susceptible to micronutrient deficiency. In this article, we summarize the preventive and therapeutic effects of micronutrients including zinc, selenium, magnesium, and chromium on diabetes mellitus.

Objective　To study the effect of the combined use of aminoguanidine (AG) and cyclosporine A (CsA) on acute rejection following cardiac allograft. Methods　Except the control group, all other three groups were respectively treated by AG 600mg/kg every day subcutaneously 0 to 7 days after transplantation, low-dose CsA 2mg/kg every day i.m 0 to 7 days after transplantation, and low-dose CsA plus AG. Inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production during acute allograft rejection were detected at 4th day after operation, and the graft survival was observed.Results　Compared with the control group, iNOS expression and NO production were significantly inhibited in the AG-treated group (P＜0.05)，the progression of acute rejection was slightly attenuated and allografted heart survival prolonged. The inhibitory effects of iNOS activity and NO production in the recipients receiving the combined treatment of low-dose CsA plus AG were higher than those receiving low-dose CsA alone. Compared with the low-dose CsA group, low-dose CsA plus AG could significantly reduce the histologic grade of acute rejection (P＜0.01) and prolong the graft survival (P＜0.05). Conclusion　The combined use of low-dose CsA and AG could synergistically suppress iNOS activity and NO production, and significantly prolong allografted heart survival.