Objective:To observe effects of electroacupuncture at Jiaji(EX-B_2)on phosphorylated extracellular signal regulated kinase(ERK)and neurokinin-1(NK-1)in dorsal horn of the complete Freund's adjuvant arthritis rat,so as to study possible mechanism of electroacupuncture analgesia from the point of view of signal conduction.Methods:Eighty Wistar adult male rats were randomly divided into normal control group,simple electroacupuncture(EA)group,model 30 min group,model 24h group,model 48 h group,EA 30min group,EA 24h group,and EA 48h group,10 rats in each group.Inflammatory pain rat model was established by injection of complete Freund's adjuvant into left hindpaw.EA was given at bilateral L_3～L_5 Jiaji(EX-B_2).The pain threshold was determined and phosphorylated ERK and NK-1 expressions in the spinal cord were detected by immunohistochemical technique.Results:The pain threshold significantly decreased(all P

Objective To compare the clinical efficacies of warm needling versus salt moxibustion in treating knee osteoarthritis. Methods One hundred and twenty patients with knee osteoarthritis were randomly allocated to groupsⅠ andⅡ, and control group, 40 cases each. GroupⅠ received salt moxibustion; groupⅡ, warm needling; the control group, routine medication. After 4 weeks of treatment, the Lysholm Knee Scoring Scale scores, the VAS scores, the quality of life scores and the clinical therapeutic effects were compared between the three groups.Results There were statistically significant pre-/post-treatment differences in the Lysholm Knee Scoring Scale scores, the VAS scores and the quality of life scores in the three groups (P<0.05). There were statistically significant post-treatment differences in the Lysholm Knee Scoring Scale scores and the VAS scores between groupⅠ orⅡ and the control group (P<0.05). The total efficacy rate was 90.0% in groupⅠ, 87.5% in groupⅡ and 70.0% in the control group. There was a statistically significant difference in total efficacy rate between groupⅠ orⅡ and the control group (P<0.05).Conclusions Warm needling and salt moxibustion are both effective way to treat knee osteoarthritis and have equal therapeutic effects.

Objective To compare the therapeutic effect of electroacupuncture, warm needling therapy and acupuncture on the third lumbar transverse process syndrome. Methods 90 patients were assigned to receive electroacupuncture therapy (n=30), warm needling therapy (n=30) and acupuncture therapy (n=30) for 20 times. They were assessed with Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scoring systems for lower back pain before and after treatment. Results The scores of JOA increased and the scores of VAS decreased significantly in all the groups after treatment (P<0.001). Both the scores were better in the electroacupuncture group (P<0.05). Conclusion Electroacupuncture, warm needling therapy, and acupuncture are effective on the third lumbar transverse process syndrome, among which the electroacupuncture is most effective.

Objective To compare the effects of heat-sensitive moxibustion and ginger-partition moxibustion on refractory peripheral facial paralysis. Methods Fifty-five patients with refractory peripheral facial paralysis were randomized into heat-sensitive moxibustion group (N=28) and ginger-partition moxibustion group (N=27). For two cases dropped out during the treatment, a total of 25 cases were finally enrolled into the ginger-partition moxibustion group. Two groups received oral use of mecobalamin tablets and conventional acupuncture, and heat-sensitive moxibustion group was given heat-sensitive moxibustion and ginger-partition moxibustion group was given ginger-partition moxibustion additionally. The moxibustion was performed once a day and ten times constituted one course, the treatment covered 6 courses. The clinical effect of the two groups was evaluated by 40-score method, House-Brackmann facial neurological function evaluation standard, blink reflex ( BR) , electromyogram and electroneurography. Results ( 1) Symptoms integral was increased in both groups after treatment ( P<0.01) , and the scores of heat-sensitive moxibustion group were higher than those of ginger-partition moxibustion group ( P<0.01). ( 2) The markedly effective rate of heat-sensitive moxibustion group was 75.00% and that of ginger-partition moxibustion group was 44.00%, and there was statistically significant difference between them ( P<0.05). ( 3) The results of electrophysiological examination showed that the difference values of ipsilateral and contralateral BR R1, R2, R2’ in both groups after treatment were less than those before treatment ( P<0.01) , and the abnormal rate of electromyography for heat-sensitive moxibustion group was improved obviously after treatment ( P<0.01) . The amplitude of compound muscle action potentials ( CMAP) of orbicularis oculi/orbicularis oris at the affected side of both groups showed a decreasing trend, but the differences were insignificant between the two groups after treatment ( P>0.05). Conclusion The curative effect of heat-sensitive moxibustion for the treatment of refractory peripheral facial paralysis is better than that of ginger-partition moxibustion.

Objective To observe the effect of ultrafine herb moxibustion on nasal mucosal remodeling in rats with allergic rhinitis. Methods Forty SD rats were randomly divided into control group (Group D) and modeling group. When successfully induced by intraperitoneal injection, aerosol inhalation and nasal spray of ovalbumin, the modeling group were randomly subdivided into modeling group (Group A), fluticasone propionate group (Group B) and ultrafine herb moxibustion group (Group C). Comparisons were made between the groups in respect of HE staining, transmission electron microscopy and counts of EOS. Results (1) Compared with Group D, Group A had significant elevation in counts of EOS (P<0.01);mucosal epithelium swelling, apparent angiotelectasis and eosinophilic infiltrated by HE staining; incomplete mucosal surface with deformity cilia, swelling mitochondria and partial loss of the mitochondria ridge by TEM . ( 2 ) Counts of EOS in Groups B and C were significantly decreased than in Group A (P<0.05, and P<0.01). Those in Group C were significantly decreased than in Group B (P<0.05), and there was insignificant difference in the counts between Group C and Group D (P=0.539). The HE staining Group B showed mild telangiectasia, with EOS scattered. The HE staining in Group C showed epithelial minor swelling and no telangiectasia. TEM showed mucosal surfaces in Groups B and C were complete, the quantity of cilia and microvillus increased apparently and cell junctions were normal. Normal endoplasmic reticulum and mitochondria were evident in Group C. Conclusion The ultrafine herb moxibustion can relieve the clinical symptoms, slow down and even reverse the nasal mucosal remodeling.

Objective To explore the efficacy of the retrosigmoid sinus approach through the cerebellopontine angle in the treatment of pontine hemorrhage.Methods A retrospective analysis was performed on 108 patients with pontine hemorrhage in Kaifeng Central Hospital from January 2016 to June 2022.They were divided into two groups according to the treatment methods,the conservative treatment group and the craniotomy treatment group(transcerebellopontine angle sigmoid sinus posterior approach).There were 94 cases in the conservative treatment group and 14 cases in the surgical treatment group.First analysis was conducted to examined whether there are differences in gender,age,Glasgow Coma Score(GCS)on admission,bleeding volume,comorbidities and complications between the two groups.Additional analysis was performed to analyze modified Rankin(modified Rankin scale,mRS)score and mortality rate after three month follow-up in case there was no significant difference at first analysis.Results There were no statistical differences in gender,age,Glasgow Coma Score(GCS)on admission,bleeding volume,comorbidities and complications between the two groups.After 3 months of follow-up,49 patients died in the conservative treatment group and 3 patients in the craniotomy treatment group.The mortality rates of the two groups were 52.1％and 21.4％respectively(χ2=4.600,P<0.05)).There was a statistical difference in the mortality rate between the two groups,and the mortality rate of the craniotomy treatment group was significantly lower than that of the conservative group.The modified Rankin score was 4(3,5)in the conservative treatment group and 3(2,3)in the craniotomy group(Z=-2.994,P<0.01).The modified Rankin score in the craniotomy group was lower than that in conservative treatment group after 3 months.Conclusion Microsurgery through the cerebellopontine angle retrosigmoid sinus approach to treat pontine hemorrhage can significantly reduce patient mortality and improve prognosis and is an effective surgical treatment method.

Objective To investigate the clinical efficacy of CT-guided drilling,hematoma aspiration and drainage for senile cerebellar hemorrhage.Methods A retrospective analysis was performed on 89 very old patients(75-89 years old)with cerebellar hemorrhage admitted to our hospital from January 2016 to December 2022.According to their wishes,different surgical treatments were adopted,and thus they were divided into puncture group(42 cases,CT-guided drilling,aspi-ration and drainage for hematoma)and craniotomy group(47 cases,craniotomy).GCS,preopera-tive hematoma volume,length of ICU stay,postoperative complications,mortality rate and the mRS score in 3 months postoperatively in the survival were compared between the 2 groups.Re-sults There were no significant differences in age,male ratio,GCS score,preoperative hematoma volume,recurrence rate at 24 h postoperatively and mortality rate at 3 months postoperatively be-tween 2 groups(P＞0.05).The puncture group had significantly shorter length of ICU stay(7.10±1.43 dvs 8.87±1.39 d,P=0.000)and lower intracranial infection rate(4.76％vs 19.15％,P=0.040)than the craniotomy group.In 3 months of follow-up after surgery,the rate of good mRS score was higher in the puncture group than the craniotomy group,and the mRS score was lower in the former group than the latter one(P＜0.05).Conclusion CT-guided drilling,aspiration and drainage for hematoma can reduce the infection rate and improve the prognosis,and is an effective approach in the treatment of patients over 75 years old with cerebellar hemorrhage.

Objective To compare the effects of filiform-fire needle and warming needle on rehabilitation of lateral epicondylitis. Methods 90 patients with lateral epicondylitis were randomized into 2 groups to receive filiform-fire needle and warming needle treatment respectively based on rehabilitation training. Their clinical efficacy, total and item scores of Elbow Functional Scale were compared. Results The clinical efficacy was better in the filiform-fire needle group than in the warming needle group (P<0.05). There was no significant difference in the total scores of Elbow Functional Scale between 2 groups. However, the scores of symptoms and signs improved more in the infiliformfire needle group 2 and 4 weeks after the treatment (P<0.05), while the scores of daily living improved more in the warming needle group 2 weeks after treatment (P<0.05). Conclusion Both filiform-fire needle and warming needle could recover the elbow function of lateral epicondylitis patients based on the rehabilitation training. The former is advanced in relieving symptoms and signs, while the latter is in improving daily living in short time.