Objective To explore the predictive value of thromboelastography(TEG)combined with ser-um D-dimer(D-D)and total bilirubin(TBIL)in the risk of postoperative deep vein thrombosis(DVT)in pa-tients with hip fracture.Methods A total of 120 patients with hip fracture who underwent surgical treatment in this hospital from January 2022 to January 2024 were retrospectively selected.According to the occurrence of postoperative DVT,the patients were divided into DVT group(n=34)and non-DVT group(n=86).The TEG parameters[coagulation reaction time(R),blood clot formation time(K),α angle and maximum ampli-tude of thrombus(MA)],D-D and TBIL levels were compared between the two groups before operation.Mul-tivariate Logistic regression was used to analyze the influencing factors of postoperative DVT in patients with hip fracture.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of TBIL,D-D and TEG parameters for postoperative DVT in patients with hip fracture.Results Compared with the non-DVT group,the TBIL level,R value and K value in the DVT group were significantly decreased,while the D-D level,α angle and MA value were significantly increased(P＜0.05).Multivariate Logistic regression anal-ysis showed that TBIL,D-D and TEG parameters were the influencing factors of postoperative DVT in pa-tients with hip fracture(P＜0.05).ROC curve results showed that the area under the curve of TBIL,D-D,TEG parameters combined to predict postoperative DVT in patients with hip fracture was 0.940,the sensitivi-ty was 82.4％,and the specificity was 93.0％.Conclusion TEG combined with D-D and TBIL levels have a high predictive value in postoperative DVT in patients with hip fracture,which can be used in the early evalua-tion of postoperative DVT in patients with hip fracture,and help to improve the prognosis of patients.

Objective To explore the risk factors of cardiomyopathy in patients with diabetes and their correlations with the levels of serum fork head box protein O1(FOXO1),growth differentiation factor 11(GDF11),and matrix metalloproteinase-3(MMP3).Methods 200 patients with diabetes complicated with cardiomyopathy and 200 patients with simple diabetes admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from September 2023 to April 2025 were selected to detect serum FOXO1,GDF11 and MMP3 levels,analyze their correlation with cardiac function parameters,screen risk factors through multifactor logistic regression,construct a nomogram model and a receiver operating characteristic(ROC)curve,and evaluate the diagnostic value.Results The duration of diabetes cardiomyopathy group≥10 years,the expression rate of reactive oxygen species(ROS)≥90%,the insulin resistance index and the levels of FOXO1 and MMP3 were significantly higher than those in the simple diabetes group(P<0.05),and the level of GDF11 was lower than that in the simple diabetes group(P<0.05).FOXO1 and MMP3 were positively correlated with E/e'and negatively correlated with LVEF and E/A;GDF11 was negatively correlated with E/e'and positively correlated with LVEF and E/A(P<0.05).The nomogram model showed that the weights of the influencing factors were GDF11,FOXO1,insulin resistance index,MMP3,ROS expression rate,and the course of diabetes.The model calibration was good(χ2=7.336,P=0.719).The combined diagnostic AUC of FOXO1,GDF11,and MMP3 was 0.950,which was better than that of a single indicator(P<0.05).Conclusion GDF11,FOXO1,Insulin resistance index,MMP3,ROS expression rate and the course of diabetes are risk factors for diabetes cardiomyopathy,and the combination of the three is of high diagnostic value.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.