Objective To compare the effect of different coping method on the prevention of shiver reaction in patients after transurethral resection of prostate. Methods 320 patients who were to undergo transurethral resection of prostate were collected and grouped into group Ⅰ, group Ⅱ, group Ⅲ and group Ⅳ.All cases received transurethral resection of prostate under subarachnoid-epidural analgesia. Different prevention methods were adopted in the four groups.The incidence of shiver reaction in four groups was observed. Results The incidence rate of shiver reaction in group Ⅰ and group Ⅲ decreased compared with group Ⅳ. Conclusion increase of temperature physically and intravenous injection of tramadol could decrease the incidence rate of shiver reaction in patients after transurethral resection of prostate.