Objective To investigate the effectiveness of disodium Aidi injection for cancer-related fatigue in nasopharyngeal carcinoma patients of Ⅲ-Ⅳ B stage undergoing radiotherapy and chemotherapy.Methods Eighty nasopharyngeal carcinoma patients of Ⅲ-Ⅳ B stage with fatigue symptoms from December 2011 to May 2012 in our hospital were divided into two groups.All patients received treatment of sequential 3 cycles with platinum-based chemotherapy after concurrent chemoradiation.One group of 40 patients also received intravenous infusion of disodium Aidi injection (experimental group),the other group of 40 patients only received conventional therapy (control group).Brief fatigue inventory (BFI) questionnaires data were collected at baseline,the eighth week and the twentieth week after treatment.The changes of fatigue severity and the occurrence of Ⅲ-Ⅳ degree adverse reactions in the two groups were compared.Results At the eighth week,the improvement in fatigue severity was not significantly different between two groups (x2 =1.758,P =0.32).However,significant improvement in cancer-related fatigue of experimental group was found than that of control group at the twentieth week(x2 =8.12,P =0.005).The Ⅲ-Ⅳ degree adverse reactions of experimental group were significantly lower than that of control group.Conclusion Disodium Aidi injection combined with radiotherapy and chemotherapy can improve the cancer-related fatigue of nasopharyngeal carcinoma patients of Ⅲ-ⅣB stage and it can also reduce the incidence rate of Ⅲ-Ⅳ degree adverse reactions.

Objective To explore the clinical value of microsatellite instability(MSI)combined with tumor mutation load(TMB)in evaluating postoperative recurrence and metastasis in patients with non-small cell lung cancer(NSCLC).Methods A retrospective selection was performed on the 80 patients with NSCLC undergoing radical surgery in the hospital between March 2020 and March 2021.All underwent maintenance therapy after surgery.According to presence or absence of recurrence and metastasis at 1 year after surgery,they were divided into recurrence-metastasis group(47 cases)and non-recurrence-metastasis group(33 cases).The clinical data in both groups were collected.MSI and TMB detection of pathological tissues were conducted.The value of MSI and TMB in predicting recurrenceand metastasis of NSCLC patients after surgery was analyzed and compared.Results The univariate Logistic regression analysis showed that the recurrence and metastasis of lung cancer after radical resection were related to smoking history,high tumor staging,medium and low differentiation,lymph node metastasis,MSI negative,and high TMB(P＜0.05).The results of multivariate Logistic regression analysis showed that lymph node metastasis and high TMB were independent risk factors of postoperative recurrence and metastasis(P＜0.05),while positive MSI was a protective factor(P＜0.05).Both MSI and TMB were of evaluation value for postoperative recurrence and metastasis(P＜0.05).There was no significant difference in AUC between MSI and TMB(P＞0.05).There were significant differences in AUC between combined detection and MSI(P＞0.05),but there was no significant difference between combined detection and TMB(P＜0.05).Conclusion Both MSI and TMB have evaluation value for postoperative recurrence and metastasis.There are differences between combined detection and MSI,but there is no significant difference between combined detection and TMB,which indicates that single TMB has good detection value.

Objective:To investigate the changes of strains based on feature tracking in patients with hypertrophic obstructive cardiomyopathy (HOCM) after surgical myectomy and the potential factors that influenced post-myectomy global strains.Methods:A total of 27 patients with HOCM who underwent septal myectomy in Fuwai Hospital from June 2014 to July 2017 were retrospectively collected. They all received cardiac MR (CMR) cine acquisitions before and after surgery. Their preoperative and postoperative strain parameters, including radial strain (RS), circumferential strain (CS), and longitudinal strain (LS) of the global left ventricle, septum, and lateral wall, were assessed by feature tracking. Comparisons of pre-myectomy and post-myectomy imaging parameters were performed using paired-samples t-test or Wilcoxon matched-pairs signed-ranks test. Pearson or Spearman correlation analysis and linear regression analysis were utilized to find the correlated factors of postoperative global strains. Results:Compared with preoperative strains, postoperative global LS, septal LS, lateral RS, lateral CS, and lateral LS increased statistically (all P<0.05); postoperative global RS, global CS, and septal CS decreased (all P<0.05); no statistically significant difference was observed in septal RS ( P=0.165). Age at surgery ( r=0.428, P=0.026) and preoperative myocardial maximum ventricular wall thickness ( r=-0.587, P=0.001) were both linearly related to postoperative global RS; the further multivariate stepwise linear regressions showed that only preoperative myocardial maximum ventricular wall thickness might be correlated with postoperative global RS (adjusted R 2=0.287, P=0.002). Only myocardial maximum ventricular wall thickness was linearly related to global CS ( r=0.679, P<0.001) and global LS ( r=0.588, P=0.001), respectively; univariate linear regression revealed that preoperative myocardial maximum ventricular wall thickness might be correlated postoperative global CS (adjusted R 2=0.337, P=0.001) and postoperative global LS (adjusted R 2=0.281, P=0.003), respectively. Conclusions:Cardiac surgery definitely relieves left ventricular outflow tract obstruction and generally improves longitudinal and lateral strains, but a negative impact may occur in global and septal CS and RS. Preoperative maximum ventricular wall thickness may affect postoperative global strains.