1.To promote the teaching of higher education reform with teaching examination
Chinese Journal of Medical Education Research 2002;0(01):-
The article analyzed the problems existing in universities’teaching inspection of teachers,students and the inspection itself and put forward some corresponding countermeasures such as updating the concept,having diverse form and making clear the dialectical relations among the lessons before class and in the class and after-school classes,strengthening and constraining the teaching inspection with the system and making reform in teaching concepts,contents and methods,and several other spects so as to achieve the overall objective of improving the teaching quality.
2.Analysis of national planning TCM textbooks for new century
Chinese Journal of Medical Education Research 2006;0(11):-
In this thesis,the background information of national planning TCM textbooks for new century is introduced. The main parts as well as the gains and loss of this national planning textbooks are also under discussion. Some suggestions are given by the author in regard to the construction of this kind of textbooks.
3.The construction of IL education system in medical colleges
Chinese Journal of Medical Education Research 2005;0(05):-
The aim of information literacy(IL) education is to cultivate students' ability to continuously update and improve their expertise.An overall IL education system contains three parts-information technology education and its' combination with medical science,information retrieval education and its' combination with medical science,and the building of good study environment based on information.
4.Strengthening Information Literacy Education and Innovating Traditional Chinese Medicine Talents Cultivating Mode
Journal of Medical Informatics 2009;30(8):92-95
Based on literature review, questionnaire survey, Interact investigation, experts interview and seminars the paper analyzes the status quo of the information literacy education and existing problems in traditional Chinese medicine colleges and universities, proposes constructive advices on carrying out information literacy education, moreover, provides a information literacy education standard for traditional Chinese medical colleges and universities and initially constructs a comprehensive information literacy education system.
5.Application of corneal densitometry in clinical practices
Hanchao GUO ; Shengwei REN ; Dongqing ZHAO
Chinese Journal of Experimental Ophthalmology 2021;39(5):454-458
Corneal densitometry is a biological property of corneal tissue, which is related to the transparency of cornea, and can be used to describe the degree of corneal transparency.At present, corneal densitometry has been used in the auxiliary diagnosis and severity evaluation of corneal diseases, as well as in the evaluation of the surgical outcome and the postoperative follow-up, even some systemic diseases affecting the cornea.The measurement of corneal densitometry is an objective, non-invasive and repeatable method to evaluate corneal transparency, which has important reference values for the monitoring of corneal and systemic health.In this article, the application of corneal densitometry in clinical practices was reviewed.
6.EFFECTS OF GANODERMA LUCIDUM POLYSACCHARIDES ON ANTIOXIDANT ABILITY AND MODALITY IN THE HIPPOCAMPUS OF AD RATS
Yanjun GUO ; Hua YUAN ; Lina ZHANG ; Shengwei GAN
Acta Anatomica Sinica 2002;0(05):-
Objective To observe the effects and mechanism of Ganoderma Lucidum Polysaccharides (GLP) on the activity of superoxide dismutase(SOD), the content of malondialdehyde(MDA) of hippocampus tissue and the learning and memory ability. Methods AD rats induced by A? 25-35 were treated with GLP for 7 days and then observing the Morris water maze to study the learning and memory ability, the content of MDA, and the activity of SOD was measured in the hippocampus tissue with spectrophotometer. Ultrastructural changes of neuron were viewed under transmission electron microscope. Results GLP can distinctly improve the learning and memory ability of A?-injected rats(P
7.Reconstruction of adjacent large finger pulps with the modified sensate free proximal ulnar artery perforator flap
Jiadong PAN ; Miaozhong LI ; Kejie WANG ; Yaopeng HUANG ; Shengwei WANG ; Shanqing YIN ; Wenquan DING ; Hao GUO ; Xin WANG
Chinese Journal of Microsurgery 2018;41(4):329-333
Objective To study the surgical techniques and the clinical curative ettect of the reconstruction of adjacent large finger pulps with the modified sensate free proximal ulnar artery perforator flap.Methods From February,2013 to May,2016,20 fingers in 10 patients with adjacent large finger pulp defects crossing the DIP joint were reconstructed by the modified senate free proximal ulnar artery perforator flap.All the pulps of every patient were recovered by 1 flap in the first stage and the artificial syndactyly of two digits was divided in 7 weeks after the flap transfer in the second stage.In order to reconstruct the sensation of two pulps in each patient,firstly both of the proximal and distal ends of the cutaneous nerve in flaps were dissected and anastomosed with the most lateral and medial palmar digital nerves of two adjacent fingers respectively,which were divided into 2 groups.Secondly the cutaneous nerve in the middle part of flap was cut and the two ends were anastomosed with the other two palmar digital nerves in the second surgery.There were 8 fingers in 4 patients with the index and middle finger pulp defects,12 fingers in 6 patients with the middle and ring finger defects.The flap size was from 5.0 cm×3.5 cm to 5.5 cm×4.0 cm,and the perforator artery was anastomosed with the palmar digital artery in 6 cases and with the joint branch of digital artery in 4 cases.Results Nine flaps survived uneventfully except the venous congestion was found in 1 flap which was salvaged successfully by acupuncture bleeding.Also,no congestion or ischemia of all the 20 pulp flaps occurred right after releasing the artificial syndactyly.The time of followed-up was from 11 months to 32 months with the average of 17 months after the second surgery.The static two point discrimination of the 2 groups of the sensate pulp flap was (7.3 ± 1.2) mm and (8.6 ±2.4) mm respectively.There was no significant difference between groups (P > 0.05).These 20 pulp flaps were also assessed by the Semmes-Weinstein monofilament test with the result of diminished light touch in 14 pulps and diminished protective touch in 6 pulps.The total active motion in all 20 fingers was (248.0±4.5) °.No patients suffered cold intolerance and local pain but 1 had hypersensitiveness in the pulp flap.Conclusion The modified sensate free proximal ulnar arte~ perforator flap is a practical alternative for the reconstruction of two large adjacent pulps with satisfactory functional and aesthetic outcomes.
8.The effect of noise exposure on insulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.
Lijie LIU ; Cong FANG ; Jing YANG ; Hongyu ZHANG ; Yi HUANG ; Chuanying XUAN ; Yongfang WANG ; Shengwei LI ; Jun SHA ; Mingming ZHA ; Min GUO
Environmental Health and Preventive Medicine 2018;23(1):6-6
BACKGROUND:
Epidemiological studies have suggested that noise exposure may increase the risk of type 2 diabetes mellitus (T2DM), and experimental studies have demonstrated that noise exposure can induce insulin resistance in rodents. The aim of the present study was to explore noise-induced processes underlying impaired insulin sensitivity in mice.
METHODS:
Male ICR mice were randomly divided into four groups: a control group without noise exposure and three noise groups exposed to white noise at a 95-dB sound pressure level for 4 h/day for 1, 10, or 20 days (N1D, N10D, and N20D, respectively). Systemic insulin sensitivity was evaluated at 1 day, 1 week, and 1 month post-noise exposure (1DPN, 1WPN, and 1MPN) via insulin tolerance tests (ITTs). Several insulin-related processes, including the phosphorylation of Akt, IRS1, and JNK in the animals' skeletal muscles, were examined using standard immunoblots. Biomarkers of inflammation (circulating levels of TNF-α and IL-6) and oxidative stress (SOD and CAT activities and MDA levels in skeletal muscles) were measured via chemical analyses.
RESULTS:
The data obtained in this study showed the following: (1) The impairment of systemic insulin sensitivity was transient in the N1D group but prolonged in the N10D and N20D groups. (2) Noise exposure led to enhanced JNK phosphorylation and IRS1 serine phosphorylation as well as reduced Akt phosphorylation in skeletal muscles in response to exogenous insulin stimulation. (3) Plasma levels of TNF-α and IL-6, CAT activity, and MDA concentrations in skeletal muscles were elevated after 20 days of noise exposure.
CONCLUSIONS
Impaired insulin sensitivity in noise-exposed mice might be mediated by an enhancement of the JNK/IRS1 pathway. Inflammation and oxidative stress might contribute to insulin resistance after chronic noise exposure.
Animals
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Biomarkers
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metabolism
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Inflammation
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physiopathology
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Insulin Receptor Substrate Proteins
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genetics
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metabolism
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Insulin Resistance
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genetics
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immunology
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MAP Kinase Signaling System
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physiology
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Male
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Mice
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Mice, Inbred ICR
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Mitogen-Activated Protein Kinase 8
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genetics
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metabolism
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Noise
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adverse effects
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Oxidative Stress
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physiology
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Proto-Oncogene Proteins c-akt
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genetics
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metabolism
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Random Allocation
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Time Factors