Objective:In order to investigate the influence of Herba Artiemisiae Capilloais on the UDPGT activity in rat's hepat.Methods: The UDPGT activities induced by Herba Artemisae capillaris were determined by the Black's assay.Results: Herba Artemisiae capillaris increased the activity of UDPGT in rats' hepat and also increased the ratio of liver weight/body weight. Conclusions: Herba Artemisiae capillaris was able to induce the acitvity of UDPGT in rats' hepat.

Objective:To explore the intervention effect of 321 health education guided by transtheoretical model on hemodialysis patients.Methods:A total of 107 cases of hemodialysis patients from January to December in 2019 in the Central Hospital of Panzhihua, Sichuan Province, were divided into a control group of 53 cases and a study group of 54 cases by table of random number. Patients in the control group received routine health education, and patients in the study group were intervened by 321 health education guided by transtheoretical model. The level of health literacy, symptoms, quality of life of patients in the two groups were evaluated by chronic disease patients health literacy scale, the Chinese version of Dialysis Frequency Severity and Symptom Burden Index (DFSSBI), and the Chinese version of Kidney Disease Questionnaire (KDQ) before and after the intervention.Results:After the intervention, the total score of the health literacy scale of patients with chronic diseases in the control group and the score of the three dimensions of information acquisition ability, communication and interaction ability, and willingness to be healthy were (89.16±11.04), (32.62±3.51), (31.48±3.61), (16.85±2.57), lower than those of the study group (99.86±11.46),(35.92±3.42),(35.73±3.92),(19.96±2.77), respectively, and the differences were statistically significant ( t values were -21.898--4.925, P<0.01). After the intervention, the total score, physical symptom score and psychological symptom score of the two dimensions of DFSSBI in the control group were (56.39 ± 8.21), (47.27 ± 6.85), (9.12 ± 1.31),higher than those of the control group (49.00 ± 6.31), (41.81 ± 5.35), (7.17 ± 0.95),respectively, and the differences were statistically significant ( t values were 5.226, 4.599, 8.827, P<0.01). After the intervention, the incidence of difficulty in falling asleep, fatigue, dry skin, itching, dry mouth in the study group were 38.89%(21/54), 38.89%(21/54), 27.78%(15/54), 27.78%(15/54), 25.93%(14/54), lower than those in the control group 66.04%(35/53), 62.26%(33/53), 49.06%(26/53), 49.06%(26/53), 45.28%(29/53), respectively, and the differences were statistically significant(χ 2 values were 5.124-9.224, P<0.05 or <0.01). The symptom scores of difficulty in falling asleep, fatigue, dry skin, itching, dry mouth in the control group were (7.44 ± 0.81), (7.34 ± 0.72), (7.42 ± 0.73), (8.62 ± 0.72), (7.82 ± 0.77), higher than those in the study group(6.11 ± 0.65), (6.02 ± 0.59), (6.15 ± 0.61), (7.12 ± 0.65), (5.84 ± 0.51) respectively, and the differences were statistically significant ( t values were 9.376-15.710, P<0.01). After the intervention, the total score of KDQ and the scores of physical symptoms, fatigue and depression in the control group were (106.46 ± 13.39), (23.87 ± 2.40), (22.71 ± 2.67), (22.52 ± 2.93), lower than those in the study group (116.89 ± 14.59), (27.12 ± 2.53), (25.16 ± 2.82), (27.12 ± 3.75), respectively, and the differences were statistically significant ( t values were -7.062--3.851, P<0.01). Conclusions:Intervention of 321 health education guided by transtheoretical model on hemodialysis patients can improve their health literacy and symptoms, reduce their symptom burden score and improve their quality of life.

Objective To investigate the correlation between autophagy related gene(ATG) locus polymorphism and the pulmonary tuberculosis(PTB) susceptibility according to the frequency distribution characteristics of autophagy related gene in the patients with PTB.Methods Eighteen single nucleotide polymorphism (SNP) loci of autophagy related genes in 202 patients with PTB as the case group and 222 healthy controls were genotyped by SequenomMassArray mass spectrometry array technology.The correlation between the each locus genotype and the PTB susceptibility was statistically analyzed.Results In the PTB patients group and healthy control group,after correcting the factors of sex and age,the binary Logistic regression analysis found that the frequency distribution of genotype and allele had statistical difference between rs5973822 and rs807185 sites in ATG4A gene (P＜0.05).The stratified analysis by body mass index (BMI) found that this difference was more significant in the high BMI population,moreover the distribution frequency in the patient group was lower than that in the control group,and the other 16 SNP loci had no statistical difference.Conclusion ATG4A gene rs5973822 and rs807185 loci polymorphism may be negatively correlated with PTB susceptibility,moreover which is more significant in the high BMI group.

Objective To investigate the feasibility and efficacy of treating atrial fibrillation(AF)in beating heart surgery using bipolar Radiofrequency Ablation(RFA)system. Methods Treating AF in beating heart under normal temperature CBP surgery with bipolar RFA following the circuit of maze operation,2 - 6 times each place,until sinus rhythm appeared,then perform AVR or MVR in the stopped beating heart. Results All 18 cases survived the surgery. Sinus rhythm appeared in all cases. The average treating time was 28 minutes. Conclusions Application of bipolar RFA in the treatment of AF in beating heart is a safe and efficacy method. It is recommended to be applied widely.

Objective: To explore the value of echocardiography in diagnosis of congenital unicuspid aortic valve (UAV). Methods: Totally 20 patients with UAV diagnosed by echocardiography were retrospectively analyzed. Results: Valve dysfunction was observed in all 20 patients. Simple stenosis of aortic valve was found in 6 cases (6/20, 30.00%), while simple regurgitation was detected in 3 cases (3/20, 15.00%).Two cases (2/20, 10.00%) showed no attachment point, 18 cases (18/20, 90.00%) showed attachment point mostly located in 1-7 o'clock. The ascending aorta enlarged after narrowing in 17 cases. Nine cases were found with other congenital heart diseases, while complications were noticed in 4 cases. Conclusion: Echocardiography can diagnose congenital UAV at early stage by showing the anatomy and movement of UAV in real time, providing reliable basis for treatment and prognosis assessment.

Objective: To observe the value of real-time three-dimensional echocardiography (RT-3DE) for evaluating left ventricular global and regional systolic function in children with left ventricular noncompaction (LVNC). Methods: According to left ventricular ejection fraction (LVEF) detected with conventional echocardiography, 34 children with LVNC were divided into LVEF normal group (group A, LVEF≥50%, n=25) and LVEF reduced group (group B, LVEF<50%, n=9), while 20 healthy children were selected as normal control group (group C) at the same period. RT-3DE examinations were performed, left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV) and LVEF were measured. The ratio of noncompaction myocardium to compaction myocardium (NC/C) at the thickest area on end-systolic count were calculated. The involvements of left ventricular 17-segment myocardium were observed. Regional end-diastolic volume (rEDV), regional end-systolic volume (rESV) and regional ejection fraction (rEF) were obtained with left ventricular volume-time curve analysis. The data were statistically analyzed. Results: There was no statistical difference of LVEDV (t=-0.17, P=0.87), LVESV (t=0.79, P=0.44) and LVEF (t=-1.72, P=0.10) between group A and C, nor of LVEDV (t=1.62, P=0.15) between group B and C. In group B, LVESV significantly increased (t=2.85, P=0.03), while LVEF significantly decreased compared with that in group C (t=-6.15, P<0.01). No statistical difference of NC/C was found between group A and B (t=-1.15, P=0.27), but the number of affected segments in group A was significantly fewer than that in group B (t=-4.59, P=0.03). There was no statistical difference of rEDV and rESV in all of 17 segments of myocardium in left ventricular between group A and C (all P>0.05), while rEF of apical septal, inferior and lateral segments, as well as med inferoseptal, inferior and inferolateral segments were significantly different between group A and C (all P<0.05). There was no significant difference of rEDV in all 17 segments of myocardium in left ventricular between group B and C (all P>0.05), while rESV of basal inferolateral and anterolateral segments, med anterior, anteroseptal, inferior, inferolateral and anterolateral segments, apical anterior, septal and lateral segments, as well as rEF in all 17 segments of myocardium in left ventricular were significantly different between group B and C (all P<0.05). Conclusion: RT-3DE can be used to evaluate the regional and global systolic function, which is helpful to early diagnosis, treatment and prognosis of LVNC children.

Cardiac masses with complicated sources and various classifications often locate on the walls and chambers of heart and interlink great vessels. Insidious onset and sudden appearance symptoms threaten the survival of patients. Multimodality imaging plays an important role in the fields of diagnosis, treatment and prognosis evaluation of cardiac masses. The advancements of multimodality imaging in diagnosis of cardiac masses were reviewed in this article.

Hypoxic ischemia (HI) is a fatal cause of neonatal encephalopathy and death. The developing brain can adjust the structures and function of brain according to different states due to neural plasticity. Understanding the pathophysiological process and cerebral network reorganization of neural damage after HI is very important for early diagnosis and intervention of disease. The research progresses of mechanism of neonatal cerebral network reorganization following HI were reviewed in this article.

Hepatitis B virus (HBV) infection is a major public health problem worldwide. With the extensive prophylactic vaccination with hepatitis B vaccine for neonates and an increasing number of patients receiving antiviral treatment, remarkable achievements have been made in HBV infection among Chinese children. However at present, there is still a high HBsAg-positive rate among the adults in China, and with more and more special populations, it is necessary to perform timely screening and diagnosis and give antiviral therapy as early as possible, so as to prevent or delay the progression to liver cirrhosis, liver failure, and hepatocellular carcinoma after HBV infection. The selection of treatment timing and drugs should not only focus on HBV virology and liver function, but also consider chronic underlying diseases, mother-to-child transmission, and reactivation of HBV in patients receiving chemotherapy and immunosuppressants, thereby realizing the timely screening, diagnosis, and treatment of the population at a high risk of HBV and special populations and bringing more benefits to patients.

OBJECTIVE: To establish a new mechanical model of distal humerus in children with epiphysial cartilage, stimulate supracondylar humerus fracture and perform three dimensional finite elements, and study effect of pins numbers, pin tract, outlet height and pin configurations on stability of fixation. METHODS: Three dimensional computed tomography (CT) data of 6-year-old boy with distal humerus was downloaded from picture archiving and communications systems software (PACS), the data of picture was imported into Simpleware and SolidWorks 2016 software to establish distal humerus fracture in children contained ossific nucleus of the capitellum (ONC) and distal cartilage. Normal extense supracondylar humerus fracture model was established to stimulate configurations of crossed and lateral pinning fixation, 30 N was added on the direction of flexion extension and varus valgus, while 50 N was added on the direction of internal and external turning. Stability was analyzed by displacement degree of distal fracture. RESULTS: Among 2-pin configurations, 2-crossed pins were more stable against rotation forces which could resist rotation stress over 2 585 Nmm/ °, while low position through ONC of 2-divergent lateral pins were more stable, which could resist stress of 45 N /mm and 190 N /mm during the test of resistant strains and varus-valgus stress. The third pins was added into the more stable lateral 2-pins, the stability in all directions were increased obviously, and 3 crossed pins is the most stable, stress of flexion-extension, varus-valgus and internal-external turning were 198 N /mm, 395 N /mm and 6 251 Nmm/ °. CONCLUSION Two-divergent lateral pins could provide enough stability for supracondylar humerus fracture in children. In two-crossed pins, the upper border of MDJ could provide the best stability. Three-crossed pins could offer the best stability against both translation and rotation forces.
Biomechanical Phenomena ; Bone Wires ; Child ; Finite Element Analysis ; Fracture Fixation, Internal ; Humans ; Humerus ; Male