Humans ; Vitamin D ; poisoning ; Vitamins ; poisoning

Object To determine the histochemical location d eposited artemisinin and to provide selection character for screening of Artemisia annua L. which contains rich content of artemisinin Methods Artemisinin was located by the histochemic al method and then statistical method was used to ascertain the correlation betw een the content of artemisinin and the density of biseriate glandular triche mes (BGT) Results Artemisinin is located in both BGT and non glandular T -shaped filamentous trichomes (NTFT) in A annua leave s The content of artemisinin had a positive correlation with the density of BG T in A annua leaves Conclusion High density of BGT in foliar tissue might be considered as one of the selection characters for the screening of A. annua with rich content of artemisinin

In order to improve the effect of teaching and teachers' ability,make our teaching methods adapt to the social development,the department of Endocrinology used the method of preparing lessons collectively in our teaching.We found that the method not only made the the supply of teachers reasonably but also made good contribution to the students' culture.Practice testified that the method of preparing lessons collectively could adapt to the new model of cultivation and create substantial results.

Objective To observe the effects ofTanyu Tongzhi Formula on proliferation and migration of human umbilical vein endothelial cells (HUVECs);To explore its activity of pro-angiogenesis.Methods HUVECs were cultured in vitro. Rats were treated with gavage containing different doses ofTanyu Tongzhi Formula (78.0, 39.0, 19.5 g/kg) to prepare serum with different doses of medicine. The activity of HUVECs was measured by MTT method. The effects on migration of HUVECs were inspected by using scratch wound assay.Results Compared with the normal control group, serum containing high-dose and medium-doseTanyu Tongzhi Formula could significantly promote the proliferation of the HUVECs (P<0.01). The rates were 49.78% and 33.92% respectively. And the cell migration rate was higher in the two groups than in the normal control group (P<0.01). The rates were 11.36% and 11.62% respectively.ConclusionTanyu Tongzhi Formula can promote proliferation and migration in HUVEC, which may be active to pro-angiogenesis.

BACKGROUND: At present, more and more scholars pay attention to the influence of spine and pelvis sagittal balance on the quality of life of patients. Postoperative changes in spine imaging parameters fol owing corrective osteotomy for lumbar degenerative kyphosis have not been reported. OBJECTIVE: To evaluate postoperative changes in sagittal balance fol owing corrective osteotomy for lumbar degenerative kyphosis. METHODS: We retrospectively analyzed 35 consecutive lumbar degenerative kyphosis patients treated with posterior osteotomy fixation in the First Affiliated Hospital of Xinjiang Medical University from February 2012 to December 2014. Imaging parameters were measured before fixation, immediately after fixation and during final fol ow-up. RESULTS AND CONCLUSION: (1) There were significant differences between preoperative and postoperative parameters except for pelvic incidence angle (P < 0.05). (2) There were significant differences between postoperative and last fol ow-up parameters except for Cobb angle, pelvic incidence angle, thoracic kyphosis angle and the thoracolumbar kyphosis (P < 0.05). (3) Pelvic tilt angle was negatively correlated with lumbar lordosis after fixation (r=-0.610, P < 0.001). Thoracic kyphosis was positively correlated with lumbar lordosis (r=0.598, P < 0.001). (4) Results suggested that lumbar sagittal contour can be significantly improved by corrective osteotomy for lumbar degenerative kyphosis. Simultaneously, reciprocal changes in the adjacent areas such as thoracic spine and pelvis occur to adapt to the new sagittal balance.

Objective To measure the tapping frequency of hemiplegic unaffected forefinger and normal control's forefinger. Methods The tapping frequency of 27 left hemiplegic patients and 32 healthy controls were measured by finger oscillating frequency tester. Results The oscillation frequency of hemiplegic patients was lower than that of the healthy controls (P<0.001). Conclusion Hand function of hemiplegic patients weakened.

Objective:To explore the effect of ICE regimen (ifosfamide, carboplatin, VP16) combined with methotrexate on the clinical efficacy and expression of miR-451a and miR-15a in patients with diffuse large B cell lymphoma (DLBCL).Methods:A total of 56 patients with DLBCL in the Third Hospital of Changsha from March 2013 to may 2018 were prospectively selected and randomly divided into observation group and control group, 28 cases in each group. The control group was treated with ICE regimen, and the observation group was treated with ICE regimen combined with methotrexate. The tumor control rate, toxic and side effects, the expression of miR-451a and miR-15a, immune function (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +), serum tumor markers [β 2 microglobulin (β 2-MG), carbohydrate antigen 125 (CA125), and lactate dehydrogenase (LDH)] levels were compared before and after treatment between the two groups, follow-up for 6 to 12 months was used to calculate the survival rate of the two groups. Results:The tumor control rate in the observation group (92.86%) was higher than that in the control group (71.43%) ( P<0.05); After treatment, the miR-15a decreased and miR-451a increased in the two groups, and the miR-15a in the observation group was lower than that in the control group, while miR-451a was higher than that in the control group ( P<0.05); After treatment, the CD3 +, CD4 +, CD4 +/CD8 + of the two groups were lower than before treatment, and CD8 + was higher than before treatment ( P<0.05), but there was no significant difference between the two groups ( P>0.05); After treatment, the serum CA125, LDH, and β 2-MG in the two groups were lower than before treatment, and the above indexes in the observation group were lower than those in the control group ( P<0.05); There was no significant difference between the two groups in the incidence of side effects and the survival rates of 6, 9 and 12 months after treatment ( P>0.05). Conclusions:ICE regimen combined with methotrexate in the treatment of DLBCL can further improve the therapeutic effect and reduce the serum tumor marker levels by regulating the expression of miR-451a and miR-15a, with less toxic side effects and less immune damage, and high safety.

Objective: To observe the effect of electroacupuncture plus drug anesthesia on pain and stress response in patients after radical surgery for stomach cancer.Methods: A total of 60 patients were randomized into a control group and an observation group by the random number table, with 30 cases in each group. The control group was given conventional drug anesthesia. The observation group was given additional electroacupuncture intervention. Before anesthesia and 2 h, 12 h and 24 h after surgery, the visual analog scale (VAS) was scored, the heart rate, the mean arterial pressure, and the levels of serum β-endorphin (β-EP) and adrenocorticotrophic hormone (ACTH) were measured. Results: Two hours, 12 h and 24 h after surgery, the VAS scores of both groups were higher than those before anesthesia (all P<0.05), and the VAS scores in the observation group were lower than those in the control group at the same time points (all P<0.05). Two hours, 12 h and 24 h after surgery, the heart rates and mean arterial pressures in the control group were significantly higher than those before anesthesia (all P<0.05), while there were no significant intra-group differences in the observation group (all P>0.05), and the indicators were lower than those in the control group at the same time points (all P<0.05). Two hours, 12 h and 24 h after surgery, the serum β-EP levels in the observation group were significantly higher than those before anesthesia (all P<0.05), and significantly higher than those in the control group at the same time points (all P<0.05). Two hours, 12 h and 24 h after surgery, the serum ACTH levels in the control group were significantly higher than those before anesthesia (all P<0.05), and were significantly higher than those in the observation group at the same time points (all P<0.05). Conclusion: Electroacupuncture plus drug anesthesia can significantly relieve pain and stress response in patients after radical surgery for stomach cancer.

Cancer-related fatigue(CRF) is one of the important symptoms for cancer patients,especially for the long-term survival patients after treatment.Its complexity and interdependency with other symptoms make it difficult to identify the clear underlying mechanisms. No single etiologic model provides a satisfactory explanation of cancer-related fatigue.For mild fatigue,non-pharmacological therapy is recommended.Non-pharmacological therapy combined with pharmacological therapies is recommended for patients with moderate and severe fatigue.

Objective To assess the effects of positions on circulation and neonatal during Caesarean section under epidural anaesthesia. Methods Eighty healthy parturients undergoing selective Caesarean section were randomly allocated in four groups with 20 cases each, who were positioned in supine (group S), left oblique 30 degress(group L), left oblique 15 degrees with 15 degrees Trendelenburg(group LT), or supine with 15 degrees Trendetenburg (group ST) position. MAP, HR,SpO_2 were recorded before and at 5 min, 10 min, 15 min during anesthesia. Apgar scores of 1-and 5-min were observed as well. Results MAP in groups of S, LT and ST was significantly lower at 10 min during anesthesia than that before or group L(P<0. 05) There was no significant difference in 1-and 5-min Apgar scores among four groups. Conclusion The left oblique 30 degrees position could effectively reduce the incidence of hypotension during Caesarean section under epidural anaesthesia