Anti-Inflammatory Agents ; therapeutic use ; Colitis, Ulcerative ; diagnosis ; drug therapy ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine

Objective To observe the effect of external fixator combined with limited internal fixation in the treatment of complex ankle fractures.Methods According to the digital table,65 patients with complex ankle fracture were randomly divided into treatment group(33 cases) and control group(32 cases).The treatment group was treated with external fixator combined with limited internal fixation,the control group was treated with internal fixation.All patients were followed up for 5 to 20 months.The curative effect and incidence rate of complication of the two groups were observed.Results The excellent rate of the treatment group was 84.85%,which was higher than 62.50% of the control group,the difference was statistically significant(x2=4.20,P<0.05).The incidence rate of complications in the treatment group was 3.03%,which was lower than 18.75% of the control group,the difference was statistically significant(x2=4.18,P<0.05).Conclusion External fixator combined with limited internal fixation can effectively treat complex ankle fractures,the method can not only make patients satisfied with the reduction effect,but also the internal fixation complications such as infection are minimized,the clinical value is extremely high,it is worthy of wide application.

Objective To study the effects of nitric oxide (NO) on the growth and metastasis of tumor.Methods The literatures of recent years were reviewed.Results NO had double effects on the growth and metastasis of tumor. NO promoted the growth and metastasis by regulating the expression of tumor proliferation gene and inducing tumor angiogenesis. On the other hand, NO had antitumor effects by interfering with the metabolism of tumor cells, inducing the damage of DNA, forming high toxic free radical, inducing apoptosis of tumor cells and mediating the antitumor action of endothelial cells and macrophages.Conclusion Selective blockage or induction of synthesis of NO may be a new way for tumor therapy.

Adult ; Aluminum ; adverse effects ; Electrolysis ; Fluoride Poisoning ; epidemiology ; Humans ; Male ; Occupational Exposure ; adverse effects ; Workplace ; Young Adult

Objective To observe the clinical efficacy of intratympanic dexamethasone injection for patients with sudden sensorineural hearing loss (SSNHL). Methods Forty-four SSNHL cases (44 ears) which failed to respond to regular treatments were divided into two groups. The intratympanic injection group (24 eases) were injected dexamethasone 2.5 mg to the tympanic cavity every two days,4 times in all. The control group (20 eases) were treated with B1,B12 and triphosaden. Pure tone average (PTA) was tested before and 3 days after treatment. Results The total effective rate of intratympanic injection group was higher than that of control group [37.5%(9/24) vs 10.0%(2/20)] (P < 0.05). In intratympanic injection group, PTA of post-injection was significantly lower than the pre-injection[ (52.75±20.14) dB vs (70.26±20.76) dB ] (P < 0.05). PTA of post-injection in intratympanic injection group was significantly better than that in control group[(52.75±20.14) dB vs (63.55±19.36) dB](P< 0.05). Conclusion Intratympanic dexamethasone injection can be applied to SSNHL patients who failed to respond to systemic corticosteroid treatment and it can avoid the side effects brought on by high dose systemic corticosteroid treatment.

The development of medical institutes needs not only marvelous hardware construction,but also software strength,such as the hospital culture,brand establishment,etc.Only by the persistent and coordinated development of hardware strength and software strength,can hospital's comprehensive strength and core competitiveness be effectively improved.To enhance hospital software strength,it is necessary to cultivate hospital culture with unique features,emphasize brand establishment,devise long-term development blueprint of medical institutes and activate hospital's potential for further development.

Objective] Summarize the experience of diagnosis and treatment of plasma cell mastitis by Gu ’s surgery department. [Method] By collecting medical records, from the teachers, pathogenesis, to summarize the inheritance and development of diagnosis and treatment of plasma cell mastitis by Gu ’s surgery department three generations, according to the present situation, analysis of the problems existing in the treatment of the disease. [Results] The disease was first discovered and reported by Dr.Gu Bohua in the domestic.Gu’s surgery department gradually gropes for a set of solution method in treatment of plasma cell mastitis after three generations from the treatment based on the external therapies in the initial, to later, internal and external therapies, at present based on the internal therapies. Clinical studies have found that the internal and external therapies have advantages of high cure rate, short treatment time, but the scar is larger, while the internal therapies in the long treatment cycle achieve the same cure rate, but the scar is smaller, less expensive. But the exploration of the cause of the disease, diagnosis and standardized treatment is still fraught with problems. [Conclusion]Developing by three generations, Gu ’s surgery department provides a more complete mentality and pragmatic value in treating plasma cell mastitis.

Large amounts of clinical studies and epidemiological data have confirmed that obesity is closely related to the development and progression of endometrial cancer.The mechanism of the endometrial cancer may be involved estrogen,insulin,insulin-like growth factor,leptin,adiponectin,resistin fat factor, inflammatory factors and so on.

Objective To observe the clinical efficacy of scalp acupuncture plus body acupuncture in treating diarrhea-predominant irritable bowel syndrome (D-IBS). Method Totally 122 D-IBS patients were randomized into a scalp acupuncture group (41 cases), a body acupuncture group (41 cases), and a combined group (40 cases). The scalp acupuncture group was intervened by acupuncture at the Stomach and Intestine Zones on the head; the body acupuncture group was by ordinary body acupuncture; the combined group was by both scalp acupuncture and body acupuncture. The symptom score of traditional Chinese medicine (TCM) was evaluated prior to the treatment, at the end of the first and second treatment courses, and after the whole intervention; the clinical efficacies were also compared among the three groups. Result The symptom scores of the combined group were significantly lower than that of the scalp acupuncture group and body acupuncture group respectively at the end of the second treatment course and after the whole intervention (P<0.05); after the whole intervention, the cured and markedly-effective rate was 62.5% in the combined group, significantly higher than 24.4% in the scalp acupuncture group and 29.3% in the body acupuncture group (P<0.05). Conclusion Scalp acupuncture plus body acupuncture can produce a satisfactory clinical efficacy in treating D-IBS, better than body acupuncture or scalp acupuncture alone; its advantages include rapid onset of action, significant effect, and reducing intestinal inflammation, etc.

Objective To prepare chitosan (CS)-compound Yizhihao-nanoparticles (NP) and to investigate its antibacterial activity. Methods CS NPs were formed by the incorporation of CS and Na3PO4. CS-compound Yizhihao NPs were prepared by ion-cross-linking. The particle sizes and surface charges of CS NPs were determined by Malvern Zetasizer 1000-HAS and atomic force microscope (AFM), respectively. The antibacterial acitivity of CS-compound Yizhihao-NPs was studied in vitro and compared with that of compound Yizhihao powder. Results Malvern Zetasizer 1000-HAS and AFM demonstrated that the diameter of CS-compound Yizhihao NPs was (137.00±14.28)nm and CS NPs had (16.90±1.32)mV positive surface charges. The minimal inhibitory concentrations (MIC) of CS-compound Yizhihao NPs on Staphylococcus aureus,Pneumococcus,β-hemolytic streptococcus, and Escherichia coli were 1:32,1:32,1:16,and 1:2,respectively. The minimal bactericidal concentrations (MBC) of CS-compound Yizhihao-NPs on Staphylococcus aureus,Pneumococcus,β-hemolytic streptococcus, and Escherichia coli were 1:16,1:16,1:8, and 1:2,respectively. The antibacterial efficacy of CS-compound Yizhihao-NPs to Staphylococcus aureus,Pneumococcus,and β-hemolytic streptococcus had been improved significantly (P<0.05). Conclusion CS-compound Yizhihao-nanoparticles have obvious antibacterial activity to the Staphylococcus aureus,Pneumococcus,and β-hemolytic streptococcus,which lays the experimental foundation for new preparation of traditional Chinese medicine in future research.