Anti-Inflammatory Agents ; therapeutic use ; Colitis, Ulcerative ; diagnosis ; drug therapy ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine

Adult ; Aluminum ; adverse effects ; Electrolysis ; Fluoride Poisoning ; epidemiology ; Humans ; Male ; Occupational Exposure ; adverse effects ; Workplace ; Young Adult

Altitude Sickness ; diagnosis ; Humans ; Occupational Diseases ; diagnosis ; Reference Standards

Objective] Summarize the experience of diagnosis and treatment of plasma cell mastitis by Gu ’s surgery department. [Method] By collecting medical records, from the teachers, pathogenesis, to summarize the inheritance and development of diagnosis and treatment of plasma cell mastitis by Gu ’s surgery department three generations, according to the present situation, analysis of the problems existing in the treatment of the disease. [Results] The disease was first discovered and reported by Dr.Gu Bohua in the domestic.Gu’s surgery department gradually gropes for a set of solution method in treatment of plasma cell mastitis after three generations from the treatment based on the external therapies in the initial, to later, internal and external therapies, at present based on the internal therapies. Clinical studies have found that the internal and external therapies have advantages of high cure rate, short treatment time, but the scar is larger, while the internal therapies in the long treatment cycle achieve the same cure rate, but the scar is smaller, less expensive. But the exploration of the cause of the disease, diagnosis and standardized treatment is still fraught with problems. [Conclusion]Developing by three generations, Gu ’s surgery department provides a more complete mentality and pragmatic value in treating plasma cell mastitis.

Objective To observe the effect of external fixator combined with limited internal fixation in the treatment of complex ankle fractures.Methods According to the digital table,65 patients with complex ankle fracture were randomly divided into treatment group(33 cases) and control group(32 cases).The treatment group was treated with external fixator combined with limited internal fixation,the control group was treated with internal fixation.All patients were followed up for 5 to 20 months.The curative effect and incidence rate of complication of the two groups were observed.Results The excellent rate of the treatment group was 84.85%,which was higher than 62.50% of the control group,the difference was statistically significant(x2=4.20,P<0.05).The incidence rate of complications in the treatment group was 3.03%,which was lower than 18.75% of the control group,the difference was statistically significant(x2=4.18,P<0.05).Conclusion External fixator combined with limited internal fixation can effectively treat complex ankle fractures,the method can not only make patients satisfied with the reduction effect,but also the internal fixation complications such as infection are minimized,the clinical value is extremely high,it is worthy of wide application.

The robust nuclear-cytoplasmic transport is vital for eukaryotes'life cycle.Not only proteins and RNAs are transferred to their destination by this system, the important cellular activities such as mitosis are also regulated by the transport pathways via adjusting the local concentrations of some critical cargoes.tRNA is one of the most important biomacromolecules in the cell, synthesized in nucleus, and taking part in protein synthesis in cytoplasm.It is a long-held belief that tRNA functions only as a key player in protein synthesis, and tRNA nuclear-cytoplasmic transport is a unidirectional movement from nucleus to cytoplasm.However, the recent discoveries are overturning the traditional opinions.Nuclear-born tRNA can be exported out of nucleus, while cytoplasmic-residing tRNA can also be retrogradely transport into nucleus.The new concept tRNA nuclear-cytoplasmic dynamics was coined in 2008 to describe the tRNA communication between nucleus and cytoplasm, which was found able to regulate protein synthesis and cell cycle in S.cerevisiae.The latest results in this field are going to change the landscape of eukaryotic tRNA biology.

Objective To explore the effectiveness of short-term integrated intervention to reduce discrimination against people living with HIV/AIDS(PLWHA)among medical students.Methods A quasi-experimental survey was conducted.Two medical schools in Beijing,one as intervention group and the other as control group were selected by convenience sampling,from which 123 undergraduate students or interns of medical and nursing specialties were recruited,62 in the intervention group and 61 in the control group.The intervention group was provided with 13 hour long antidiscrimination intervention by increasing HIV/AIDS related knowledge,sympathy and skill in dealing with people living with HIV/AIDS,while the control group was deprived of any intervention.The attitude of the students in the 2 groups were assessed by questionnaire survey in 5 time points after the intervention.Results Compared with the control group,at 4 time points after the intervention students in the intervention group had less discrimination against PLWHA in general;and significantly less discrimination in dealing with them as patients(P

Objective To study the effects of nitric oxide (NO) on the growth and metastasis of tumor.Methods The literatures of recent years were reviewed.Results NO had double effects on the growth and metastasis of tumor. NO promoted the growth and metastasis by regulating the expression of tumor proliferation gene and inducing tumor angiogenesis. On the other hand, NO had antitumor effects by interfering with the metabolism of tumor cells, inducing the damage of DNA, forming high toxic free radical, inducing apoptosis of tumor cells and mediating the antitumor action of endothelial cells and macrophages.Conclusion Selective blockage or induction of synthesis of NO may be a new way for tumor therapy.

Objective To observe the clinical efficacy of scalp acupuncture plus body acupuncture in treating diarrhea-predominant irritable bowel syndrome (D-IBS). Method Totally 122 D-IBS patients were randomized into a scalp acupuncture group (41 cases), a body acupuncture group (41 cases), and a combined group (40 cases). The scalp acupuncture group was intervened by acupuncture at the Stomach and Intestine Zones on the head; the body acupuncture group was by ordinary body acupuncture; the combined group was by both scalp acupuncture and body acupuncture. The symptom score of traditional Chinese medicine (TCM) was evaluated prior to the treatment, at the end of the first and second treatment courses, and after the whole intervention; the clinical efficacies were also compared among the three groups. Result The symptom scores of the combined group were significantly lower than that of the scalp acupuncture group and body acupuncture group respectively at the end of the second treatment course and after the whole intervention (P<0.05); after the whole intervention, the cured and markedly-effective rate was 62.5% in the combined group, significantly higher than 24.4% in the scalp acupuncture group and 29.3% in the body acupuncture group (P<0.05). Conclusion Scalp acupuncture plus body acupuncture can produce a satisfactory clinical efficacy in treating D-IBS, better than body acupuncture or scalp acupuncture alone; its advantages include rapid onset of action, significant effect, and reducing intestinal inflammation, etc.

Objective To prepare chitosan (CS)-compound Yizhihao-nanoparticles (NP) and to investigate its antibacterial activity. Methods CS NPs were formed by the incorporation of CS and Na3PO4. CS-compound Yizhihao NPs were prepared by ion-cross-linking. The particle sizes and surface charges of CS NPs were determined by Malvern Zetasizer 1000-HAS and atomic force microscope (AFM), respectively. The antibacterial acitivity of CS-compound Yizhihao-NPs was studied in vitro and compared with that of compound Yizhihao powder. Results Malvern Zetasizer 1000-HAS and AFM demonstrated that the diameter of CS-compound Yizhihao NPs was (137.00±14.28)nm and CS NPs had (16.90±1.32)mV positive surface charges. The minimal inhibitory concentrations (MIC) of CS-compound Yizhihao NPs on Staphylococcus aureus,Pneumococcus,β-hemolytic streptococcus, and Escherichia coli were 1:32,1:32,1:16,and 1:2,respectively. The minimal bactericidal concentrations (MBC) of CS-compound Yizhihao-NPs on Staphylococcus aureus,Pneumococcus,β-hemolytic streptococcus, and Escherichia coli were 1:16,1:16,1:8, and 1:2,respectively. The antibacterial efficacy of CS-compound Yizhihao-NPs to Staphylococcus aureus,Pneumococcus,and β-hemolytic streptococcus had been improved significantly (P<0.05). Conclusion CS-compound Yizhihao-nanoparticles have obvious antibacterial activity to the Staphylococcus aureus,Pneumococcus,and β-hemolytic streptococcus,which lays the experimental foundation for new preparation of traditional Chinese medicine in future research.