Objective To observe the effect of vinpocetine on monoamine transmitters in cerebral of poststroke depression (PSD)rats and to investigate the mechanism of pharmacotherapeutics on PSD. Methods Rats were divided randomly into the sham-operated group,the normal saline group,the low dose of vinpocetine group and the high dose of vinpocetine group. Giving the left middle cerebral artery occlusion, the PSD rat model was established by unexpected chronic mild stress. When the PSD rat model was established, vinpocetine group was given vinpocetine(5mg/kg, 10mg/kg) and the normal saline group was given normal saline. Then the ethological score of depression was evaluated on 14 and 28 days. The monoamine transmitter in the frontal cortex and hippocampus and brainstem were detected by the fluorospectrophotometry. Results On the 28th day after the model establishment,compared with the normal saline group, the ethological score of depression level was decreased obviously. Compared with the normal saline group, vinpocetine could improve the ethological score of depression level of the PSD rat model, and these concentrations of 5-hydoxytrypatarmine ( 5-HT), noradrenalin ( NE ) and dopamine ( DA ) in the frontal cortex, hippocampus and brainstem. The level of NE ( ( 192.4 ± 34.8 ) ng/g, ( 206. 0 ± 41.7 ) ng/g,(91.1 ±23.0) ng/g] ,5-HT( (494. 1 ± 50.7) ng/g, (599.7 ± 39.2) ng/g, (541.7 ± 62.6) ng/g) and DA ( ( 298.6 ± 32.6) ng/g, ( 297.0 ± 38.1 ) ng/g, ( 85.9 ± 24.3 ) ng/g) in the high dose of vinpocetine group were significantly higher than that in the normal saline group ( NE (92.4 ± 17.5 ) ng/g, ( 131.4 ± 34.8 ) ng/g, (49.0 ±13.6)ng/g;5-HT(367.8 ±87.3) ng/g,(498.7 ± 79.6) ng/g, (320.4 ±59.4) ng/g; DA( 106.1 ±23.0)ng/g,(97.0 ±21.7)ng/g, (50.4 ± 13.8 )ng/g)(P ＜ 0.01 ). There were increased obviously by the high dose than the low dose of vinpocetine group. Conclusion Vinpocetine could treat PSD by increasing the level of monoamine transmitters in PSD rats' brain.

ObjectiveTo observe the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function. MethodsA total of 64 patients with acute post-stroke depression were randomly divided into Vinpocetine sustained-release capsules group( 34 cases) and control group(30 cases). Conventional therapy was given to both groups. To the treatment group, vinpocetine sustained-release capsules was given at the same time. Depression status was assessed with Hamilton Rating Depression Scale(HAMD). Meanwhile ,Mimi-Mental State Examination( MMSE), National Institutes of Health Stroke Scale(NIHSS) and Activities of Daily Living(ADL)were given in to both groups. ResultsAfter 6 to 12 weeks' therapy, the total score of HAMD, NIHSS and ADL of Vinpoeetine group were significantly lower than the control group ( all P ＜ 0.05 ), MMSE score increased significantly ( P ＜ 0.05 ) in Vinpocetine group. The curative rate and effective rate of Vinpocetine group were 38％ and 91％. It was significantly higher than the 20％ and 73％ of the control group ( all P ＜ 0.05 ). ConclusionVinpocetine sustainedrelease capsules was effective to treat post-stroke depression. It could improve the emotional state of patients and promote the recovery of neurological function.

Child ; Communicable Diseases ; epidemiology ; Humans ; Nutritional Status ; Zinc ; deficiency

Drugs, Chinese Herbal ; pharmacology ; Humans ; Kidney Failure, Chronic ; mortality ; physiopathology ; Renal Dialysis ; methods ; mortality ; Survival Rate

Choristoma ; Ear Diseases ; Female ; Glioma ; Humans ; Mastoid ; Middle Aged

Abdomen ; physiopathology ; Child ; Child, Preschool ; Compartment Syndromes ; diagnosis ; mortality ; therapy ; Female ; Humans ; Infant ; Male ; Retrospective Studies

Ear Canal ; pathology ; Humans ; Leukemia, Promyelocytic, Acute ; pathology ; Male ; Neoplasm Recurrence, Local ; Young Adult

AlM: To investigate the influences of 577nm panretinal photocoagulation ( PRP ) on the retinal thickness of macular fovea on diabetic retinopathy ( DR) .METHODS:A total of 45 eyes of 37 cases suffering from preproliferative diabetic retinopathy ( PPDR ) and proliferative diabetic retinopathy ( PDR ) undergoing 577nm PRP were enrolled in this study. The alterations of the retinal thickness of macular fovea measured by optovue optical coherence tomography( OCT) before and 1, 3, 6mo following PRP were comparatively analyzed.RESULTS: The macularfoveal retinal thickness after 1, 3mo of PRP had significantly increased that before operation (P<0. 05). After 6mo postoperative follow-up, it gradually recovered to the level before PRP, with no significant difference (P>0. 05).CONCLUSlON: After the treatment of PRP, it appeared a transient increase on the retinal thickness of macular fovea, but after 6mo following-up, the macular foveal retinal thickness decreased nearly to the levels before PRP.

Objective To study the situation of pathogenic bacteria of neonate infection in hospital,so can guide clinical doctors use antibiotic rationally. Method The secretions of 159 neonates′ umbilous and eye matter orders were collected to be used as the specimen and the drug susceptibility experiment was done using MIC and K-B methods together in 159 neonates with hospital infection.Results One hundred and eighty-nine pathogenic bacterias were isolated from 1613 specimens.According to our materials,staphylococci aureus was the most important pathogenic bacteria,then staphylococci heamolyticus,staphylococci epidermidis,encherichia coli ,enterobater cloucac ,klebsiella pneumoniae.MRSA- positive rate was 52.6%,ESBLs-positive in E coli was 21%,inklebsiella pneumoniae was 20%.Drugs of sensitivity for Gram positive coccus were vancomycin(0) clindamycin(8.5%) cipnofloxacin(12.2%);the drugs of sensitivity for Gram negative ord were imipenem (4.4%),cipnofloxacin(5.3%),amikacin(12.7%).Conclusion It is instructive that use antibiotic rationally for controlling neonate infection in hospital.

Objective To establish healthy adults in shenzhen longhua district reticulocyte red blood cell hemoglobin content of normal reference value range (CHr),and analyze its clinical significance.Methods By Sysmex XN-9000 automatic blood cell analyzer to detect CHr content in the blood,and 600 healthy adults to establish CHr reference range.At the same time detection of 40 patients with iron deficiency anemia (IDA)CHr content in the blood to contrast analysis.Results 18~30, 31~40,41~50,51~60 and >60 years old healthy male and female CHr content in the blood,respectively 36.35±3.26 pg and 33.95±2.81 pg,36.02±3.01 pg and 34.15±3.14 pg,36.41±2.76 pg and 34.21± 2.67 pg,35.96±3.06 pg and 33.83±3.04 pg,36.09±2.86 pg and 34.10±2.89 pg,with gender differences between different age groups had no statisti-cal significance (t=1.34~1.82,P>0.05),the difference was statistically significant between different genders is the same age group (t=4.62~5.26,P< 0.05).CHr levels in both men and women respectively reference range 36.12±3.16 pg and 34.05±2.94 pg,men than women,the results between the difference was statistically significant (t=6.792,P<0.05).Pa-tients with IDA CHr levels in both men and women,respectively 24.72±3.91 pg and 22.63±3.76 pg,significantly lower than healthy people,the results between the difference was statistically significant (t=11.29~13.02,P<0.01).Conclusion Shenzhen longhua area different gender differences between healthy adults of CHr content reference interval,men than women.IDA patients serum CHr significantly lower than the general population.Therefore,the establishment of different gender healthy adults of CHr content reference interval,diagnosis,differential diagnosis,curative effect judgment of anemia and early monitoring the extent of the hematopoietic function recovery has important clinical value.