Objective To investigate the effect of sevoflurane intravenous inhalational anesthesia and remifentanil intravenous anesthesia for single lung ventilation in the department of thoracic surgery operation .Methods 80 patients using thoracic surgery were randomly divided into the two groups with 40 cases in each group according to the number table methods ,the study group were treated with sevoflurane inhalation anesthesia while the control group were treated with remifentanil intravenous anesthesia .HR,MAP and SBP of the two groups before induction of anes-thesia(T0),1min before intubation(T1),10min after ventilation(T2),30min after ventilation(T3) and 1min before extubation(T4) were compared,and recovery time,extubation time,directional force the recovery time were recorded of the two group.Results The HR in the two groups at T1,T2,T3,T4 time did not change significantly than T0 time, while MAP decreased significantly than T0 time,with significant difference (t =8.12,7.82,8.14,8.05,all P <0.05),and there was no statistically significant difference between the two groups (P >0.05);The SBP in the study group did not change obviously at each time while the SBP in the control group at T 1 decreased significantly than T0 time,while it increased significantly at T 2 time than T1 time,with a significant difference ( t=10.51,5.34, 5.05,5.06,all P<0.05);The patients in study group were elevated blood pressure during anesthesia or decreased more than 30% occurred in 8 cases while the control group occurred in 24 cases,there was significant differences between the two groups (χ2 =13.33,P<0.05);The postoperative recovery time ,extubation time and orientation recovery time of the study group patients were (11.4 ±5.1)min,(13.4 ±6.8)min,(18.9 ±5.8)min,which were significantly lower than (19.5 ±5.2)min,(26.5 ±7.6)min,(21.9 ±7.8)min of the control group(t=5.34,6.12, 6.15,all P<0.05).Conclusion Sevoflurane intravenous inhalational anesthesia has a better anesthetic effect for single lung ventilation in the department of thoracic surgery operation than remifentanil intravenous anesthesia ,and it can effectively maintain hemodynamics stability .

Objective To investigate effects of inhalation of sevoflurane at different time on pulmonary function and oxidative stress in patients with one lung ventilation.Methods 80 patients who needed external surgery according to the random grouping principle,were divided into sevoflurane preconditioning group(OLV for 30min after inhalation of sevoflurane),sevoflurane treatment group(OLV inhalation of sevoflurane),sevoflurane inhalation group(inhalation of sevoflurane),total intravenous group(propofol and remifentanil anesthesia) four groups,20 patients in each group,each group was treated accordingly.The differences of serum malondialdehyde(MDA),superoxide dismutase(SOD),lactate dehydrogenase(LDH) and intrapulmonary shunt(Qs/Qt) in the four groups were observed and compared at different time points.Results Compared with the other three groups,the intrapulmonary shunt fraction of the sevoflurane preconditioning group were significantly lower[(4.9±0.6)% vs.(6.1±0.5)%,(6.3±0.6)%,(5.9±0.4)%](x2=5.415,5,882,4.977,all P<0.05).The serum levels of MDA,SOD,LDH in the sevoflurane pretreatment group were significantly lower than those in the other three groups[(5.06±2.10)nmol/mL vs.(13.04±3.27)nmol/mL,(12.40±4.28)nmol/mL,(13.13±2.30)nmol/ml],[(58.7±5.9)U/L vs.(84.9±13.8)U/L,(93.9±21.1)U/L,(84.2±11.2)U/L],[(16.3±2.1)U/L vs.(43.1±7.2)U/L,(45.4±6.7)U/L,(35.8±5.1)U/L](t=8.076,7.448,8.277;12.917,15.506,12.586;11.375,12.239,8.220,all P<0.05).Conclusion Thoracic surgery in patients with one lung ventilation during anesthesia,using sevoflurane preconditioning anesthesia surgery can effectively improve the patients with intrapulmonary shunt rate,reduce the level of oxidative stress and improve the prognosis,it is worthy of further clinical application.

Objective To observe the application effect of Manujet Ⅲ device combined with im-proved nasopharynx oxygen tube in painless bronchoscopy.Methods A total of 120 patients with painless bronchoscopy were selected as the research objects,and they were randomly divided into ob-servation group(treated with routine continuous nasopharynx oxygen supply and Manujet Ⅲ combined with improved nasopharynx oxygen tube)and control group(treated with routine continuous nasophar-ynx oxygen supply),with 60 cases in each group.Mean arterial pressure(MAP),heart rate(HR),the saturation of peripheral oxygen(SpO2),induction time,microscopic examination time,awakening time,success rate of examination by one time,patient's satisfaction degree,physician's satisfaction degree and incidence of adverse reactions were compared between two groups.Results Repeated measurement analysis of variance showed that there were significant differences in the time,inter-group and time to group interactions of MAP,HR and SpO2 between the two groups(P＜0.05);at the time points of 5 minutes of microscopic examination,10 minutes of microscopic examination and after micro-scopic examination,the MAP in the observation group was significantly lower than that in the control group,while HR and SpO2 were significantly higher than those in the control group(P＜0.05).There was no significant difference in induction time between the two groups(P＞0.05);in the observation group,the microscopic examination time and awakening time were significantly shorter than those in the control group,while the success rate of examination by one time was significantly higher than that in the control group(P＜0.05).The patient's satisfaction degree and physician's satisfaction degree in the observation group were significantly higher than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.00％,which was significantly lower than 18.33％in the control group(P＜0.05).Conclusion The combination of routine continuous nasopharynx oxygen supply and ManujetⅢ combined with improved nasopharynx oxygen tube for su-praglottal manual assisted jet ventilation is beneficial for providing sufficient oxygen supply and re-ducing the incidence of hypoxemia.

Objective To observe the application effect of Manujet Ⅲ device combined with im-proved nasopharynx oxygen tube in painless bronchoscopy.Methods A total of 120 patients with painless bronchoscopy were selected as the research objects,and they were randomly divided into ob-servation group(treated with routine continuous nasopharynx oxygen supply and Manujet Ⅲ combined with improved nasopharynx oxygen tube)and control group(treated with routine continuous nasophar-ynx oxygen supply),with 60 cases in each group.Mean arterial pressure(MAP),heart rate(HR),the saturation of peripheral oxygen(SpO2),induction time,microscopic examination time,awakening time,success rate of examination by one time,patient's satisfaction degree,physician's satisfaction degree and incidence of adverse reactions were compared between two groups.Results Repeated measurement analysis of variance showed that there were significant differences in the time,inter-group and time to group interactions of MAP,HR and SpO2 between the two groups(P＜0.05);at the time points of 5 minutes of microscopic examination,10 minutes of microscopic examination and after micro-scopic examination,the MAP in the observation group was significantly lower than that in the control group,while HR and SpO2 were significantly higher than those in the control group(P＜0.05).There was no significant difference in induction time between the two groups(P＞0.05);in the observation group,the microscopic examination time and awakening time were significantly shorter than those in the control group,while the success rate of examination by one time was significantly higher than that in the control group(P＜0.05).The patient's satisfaction degree and physician's satisfaction degree in the observation group were significantly higher than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.00％,which was significantly lower than 18.33％in the control group(P＜0.05).Conclusion The combination of routine continuous nasopharynx oxygen supply and ManujetⅢ combined with improved nasopharynx oxygen tube for su-praglottal manual assisted jet ventilation is beneficial for providing sufficient oxygen supply and re-ducing the incidence of hypoxemia.