1.Imaging and Histopathology Correlation of Solid Papillary Carcinoma of the Breast : A Review of Four Cases.
The International Medical Journal Malaysia 2015;14(1):93-97
Solid papillary breast carcinoma is a rare type of breast carcinoma. We present four cases which highlight the
radiological and histological findings of solid papillary carcinoma. Mammogram supplemented with ultrasound
played an important role in detecting solid papillary carcinomas which usually presents as intraductal lesions or
intracystic mass with Doppler signal. Excision biopsy is a better option than core biopsy as the latter modality
may not be representative and the diagnosis of solid papillary breast carcinoma may be missed.
2.Task-Based Learning: Student’s Perception Of Their Skill In Participating In Small Group Discussions
Sharifah Sulaiha S A ; Nurjahan M I ; Nagarajah Lee
International e-Journal of Science, Medicine and Education 2009;3(1):8-12
Task-based learning (TBL) has been accepted as
an effective tool in teaching and learning activities in
most medical schools. Many studies have looked
at competencies and learning outcomes essential for
undergraduates. Among the essential competencies
are interpersonal skills and the ability to engage in a
group discussion which this study has focused on.
The evidence supporting higher interpersonal skills is
however limited because many relevant competencies
are hard to measure and require long observational
periods.
Objective
To determine students’ self-perceived value of TBL in
enhancing their interpersonal skills during the clinical
phase.
Material and Methods
All students’ (semesters 6-10) in the clinical school
of International Medical University (IMU) were
invited to participate in this cross-sectional study done
in December 2007 utilising a self-administered
questionnaire with a 5-point Likert scale. It assessed the
students’ perception on TBL sessions conducted during
their clinical attachments in the various disciplines.
Mean-scores, standard deviations, and confidence
interval were used.
Results
Response rate was 62%. The results indicated that
students were favorable in their opinion on TBL as
a suitable forum for active communication and
participation in group discussion. The results also show
that both male and female students’ have similar
perception. As for the comparison according to
semesters, this showed that students’ maturity does not
influence their perception as well.
Conclusion
In conclusion, the study has shown positive students’
perception on the effect of TBL on acquired skills such as interpersonal communication. Our findings are
consistent with many earlier studies which show
students’ perception of the method of learning as
important factor in the enhancement of their
interpersonal skills which is fundamental to clinical
practice. Further research is necessary; long-term and
larger scale observational studies would undoubtedly be
optimal to minimise response bias.
3.Prevalence Of Cognitive Impairment Among The Members Of The National Council Of Senior Citizens’ Malaysia In Day Care Centres Within The Klang Valley
Sharifah Zainiyah SY, Gunasegaran M, Muhammad Hanif MZ, Nuramalina N, Seow HC, Bharathi V
Malaysian Journal of Public Health Medicine 2011;11(2):43-48
Cognitive Impairment is common in late life and may be due to the normal process of ageing, or associated with physical or mental disorder which contributes to a decrease in quality of life, neuropsychiatric symptoms, increased disability and increased healthcare cost. The aim of this study is to determine the prevalence of cognitive impairment among the elderly members in NACSCOM in Day Care Centres within the Klang Valley and its associated socio-demographic factors such as age, gender and educational level. This cross-sectional study was conducted on 101 members of NACSCOM in Day Care Centres of Damansara,Subang Jaya and Setapak using assisted questionnaires as the research tool. The questionnaire comprising of a total of 10 questions based on Elderly Cognitive Assessment Questionnaires (ECAQ), consisted of three parts, memory, orientation and recall. One correctly answered question earned the respondent one mark. The total score for ECAQ is 10 where respondents with scores of 5 and below were identified as having cognitive impairment. Data collected was analyzed using Chi-square test (SPSS version 18). The prevalence of cognitive impairment among the elderly members of NACSCOM in Day Care Centres within the Klang Valley was 4.0%. This study also showed that there was no statistically significant association between cognitive impairment and sociodemographic factors such as age, gender and education. Prevalence of cognitive impairment among the members of NACSCOM in Day Care Centres within the Klang Valley was found to be low. This could be attributed to the fact that members actively participated in activities organized by NACSCOM. The study also did not find any statistically significant association between cognitive impairment and age, gender and education.
4.Primary squamous cell carcinoma of the thyroid--a case report.
W M Wan Muhaizan ; K S Phang ; N A Sharifah ; D al Amin
The Malaysian journal of pathology 1998;20(2):109-11
A rare case of primary squamous cell carcinoma of the thyroid is reported herein. A 64-year-old Malay lady presented with a gradually enlarging thyroid nodule for the past 6 months and underwent total thyroidectomy. Histopathology revealed a squamous cell carcinoma of the thyroid with complete resection. Possible primary tumour elsewhere was excluded. Postoperative irradiation was given and patient is still alive after 2 years of follow-up.
Desiccated thyroid
;
Carcinoma, Squamous Cell
;
Primary
;
Case Report
;
Histopathology
5.3p25 Aneusomy in Follicular Thyroid Neoplasms: A Report of Three Cases with Review of Literature
Chia WK ; Zubaidah Z ; Reena Rahayu MZ ; Rohaizak M, Asmiati A, Rafie MK, Sharifah NA
Medicine and Health 2012;7(1):47-56
Aneusomy is an early genetic event and a characteristic feature of many solid tumors. It is often associated with poor prognosis in cancer patients. The involvement of PAX8-PPARγ rearrangement in tumorigenesis of follicular thyroid lesions has been widely assessed. However, there were few reports on aneusomy of the PPARγ gene at the 3p25 locus in follicular thyroid lesions. It remains undetermined whether these abnormalities can be translated into improved diagnosis, classification, or outcome prediction. Herein, we report three cases of follicular thyroid neoplasms [two follicular thyroid carcinomas (FTCs) and one Hurthle cell adenoma (HCA)] with 3p25 aneusomy detected by fluorescence in situ hybridization (FISH). 3p25 trisomy was observed in one FTC and one HCA while 3p25 tetrasomy was observed in one FTC. Furthermore, all three lesions did not show overexpression of PPARγ protein. Hurthle cell neoplasms (HCN) are distinct clinically and histologically from other follicular thyroid neoplasms (FTN). However, the presence of the aneusomy in HCA and FTC indicates that there could be a biological continuum between the two and chromosomal gains might play an important role in the pathogenesis of these two types of neoplasms. Despite their differences, HCN and FTN may share the same early genetic event in tumour development.
6.Fine Needle Aspiration (FNA) Cytology of the Thyroid: A Cyto-Histopathological Study of 361 Cases in Hospital Universiti Kebangsaan Malaysia
Nurismah MI ; Sharifah NA ; Usama AE ; Rohaizak M ; Naqiyah I ; Jasmi A
Medicine and Health 2007;2(1):58-65
Thyroid nodules are common but thyroid malignancies are not. Fine needle aspiration (FNA) cytology is a diagnostic tool used to screen patients with thyroid nodules who require surgery. We study the diagnostic accuracy of FNA as the initial diagnostic modality in the clinical assessment of thyroid nodules. Between January 1995 until December 2000, 2131 FNA of thyroid nodules were performed. Four hundred and forty-one (20.7%) of these were unsatisfactory and 1690 (79.3%) cases were satisfactory for cytological evaluation. Histopathological diagnosis were available for 361 cases. Cyto-histopathological correlation was carried out for these cases. Our results showed a diagnostic accuracy of 96.2% with sensitivity and specificity rates of 87.7% and 98.4% respectively. Our positive predictive value is 93.4% and our negative predictive value is 96.8%. From this study, we conclude that fine needle aspiration is an important initial screening diagnostic tool for the investigation of thyroid nodules.
7.Pleomorphic Adenoma Originating from Submandibular Salivary Gland in an 8-year-old Girl: A Case Report
Gani AN ; Megat Shiraz MAR ; Siti Aishah MA ; Norazizah M ; Mazita A ; Sharifah NA
Medicine and Health 2007;2(2):164-168
Pleomorphic adenoma (PA) typically presents as a benign slow growing, painless
neoplasm of the parotid gland. PA arising from the submandibular gland in the paediatric
age group is rare. Surgical excision is the treatment of choice. A case of PA in an 8-yearold
Malay girl is presented. Clinically she presented with a painless right submandibular
mass measuring 2x2cm. A diagnosis of Pleomorphic adenoma was made on Fine Needle
Aspiration Cytology (FNAC). She underwent submandibulectomy uneventfully.
Postoperatively after two years follow up, she is asymptomatic.
8.Anaplastic Large Cell Lymphoma Presenting as a Soft
Siti-Aishah M.A. ; Salwati S. ; Idrus M. ; Rahimah R. ; Salmi A. ; Leong C.F. ; Sharifah N.A.
Medicine and Health 2008;3(1):69-74
Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3%
of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph
nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in
the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft
tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological
examination revealed that the mass was infiltrated by large lymphoid cells with marked
nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for
T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ
hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation.
Subsequently the patient developed shortness of the breath and a thoracic computed
tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also
had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The
mediastinum and endobronchial region did not show any abnormalities. She received 6
cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL,
rarely present as a soft tissue tumour and this disease should be included as a differential
diagnosis of any soft tissue mass.
9.Revisiting Pedestrian Casualties In Malaysia And The Escalating New Threats
MohdSyazwan S1 ; BabaMD ; Aqbal HA ; Azhar H ; Zulhadi M ; Sharifah Allyana SMR
Malaysian Journal of Public Health Medicine 2018;18(Special Volume (2)):104-110
Pedestrians’ fatality trend in road crashes has been improving in recent years though it remains third in rank behind motorcyclists and car occupants. Based on the statistics, young pedestrians were the most affected group and the commonest injury regions were head and legs. Pedestrian crashes occurred primarily in rural areas and straight roads and at low light environment, and often involve cars and motorcycles. In addition to existing issues of careless and illegal crossing practices, there are potential new hazards face by pedestrian, which are mobile electronic device use and electric vehicle, especially when crossing roads. Road safety programs and interventions shall consider these new issues.
pedestrian safety
;
pedestrian distraction
;
Malaysia
10.The Contribution of Reproductive Factors and Family History towards Premenopausal Breast Cancer Risk in Kuala Lumpur, Malaysia
S Mohd Razif ; S Sulaiman ; S Soraya Hanie ; E Nor Aina ; M Rohaizak ; I Fuad ; M I Nurismah ; N A Sharifah
The Medical Journal of Malaysia 2011;66(3):220-226
Breast cancer is the most common cancer among Malaysian
women. This study aimed to determine the reproductive for
premenopausal breast cancer risk in Kuala Lumpur,
Malaysia. A case-control study was conducted in 216
histopathologically confirmed cases of premenopausal
breast cancer and 216 community-based controls that were
matched by age within a 5-year period and ethnicity. The
results of this study showed that premenopausal breast
cancer risks were strongly related to parity, number of live births and family history of breast cancer. Premenopausal women with these known reproductive and family history risk factors should take extra measures to undergo appropriate screening method for early detection of breast cancer