Mycoplasma pneumoniae is frequently known as an “atypical bacterium” that can cause wide-ranging extrapulmonary manifestations. Here, we outline a case of a child, aged 9-year-old, who presented with profound proximal muscle weaknesses and a vague rash, associated with markedly elevated serum creatinine kinase (CK). Muscle biopsy suggested Juvenile Dermatomyositis (JDM) following an upper respiratory illness of M. pneumoniae origin. The child responded exceptionally well to a combined therapy of immunoglobulin, intravenous glucocorticoid and methotrexate.