Objective To study the effects of a self-controlled and totally-enclosed type perfusion skin and tissue expansion in which pressure was continuous and constant. Methods Totally-enclosed type perfusion system included single-used infusion apparatus, triplet, soft water storage bag, catheter, and common expander. Continuous pressure-constant system included inflatable infusion apparatus and common spring sphygmomanometer. Expander was filled from soft water storage bag which was put in inflatable infusion apparatus by crushed ball. The pressure of expander was controlled by patients according to pain threshold. 26 expanders were used in 20 patients in clinical practice. The volume of expander was about 100 ~ 400 ml. After 3~5 days from operation, water began to fill in the expander and stopped when the expansion area reached. Results The volume of expander was 120~640 ml and the duration of expansion was 10~16 days, average (13.6? 2.1) days, without any complication. Conclusions The tissue expansion with continuous and constant pressure and totally-enclosed perfusion is worth popularizing because of its easy preparation, simply operation, rapid expansion, safety and comfort.