Objective To observe the effect of externally-applied Honghua liquid and catus on phlebitis induced by amiodaone.Methods One hundred and two patients with phlebitis induced by injection of amiodaone for the treatment of arrhythmia were randomly divided into control group(n=50)and treatment group(n=52)from January 2012 to December 2013. Patients in the control group were independently treated only by 50 % Honghua liquid, while the patients in the observation group were treated by hot dressing with Honghua liquid followed by wet dressing of catus. The curative effects in both groups were observed and compared.Result The total effective rate in the treatment group was significantly higher than that in the control group(χ2=6.275, P<0.05).Conclusion Hot dressing with Honghua liquid combined with wet dressing with catus is a simple and effective method to treat the phlebitis induced by injection of amiodaone.