1.The comparative study of the influence of comprehensive psychological intervention and cognitive therapy on cognitive function in schizophrenia
Jicheng DONG ; Shaoli ZHANG ; Xiaolei WANG
Chinese Journal of Behavioral Medicine and Brain Science 2009;18(10):891-893
Objective To investigate the influence of comprehensive psychological intervention and cognitive therapy on cognitive function in schizophrenia.Methods A total of 80 patients with schizophrenia were randomly divided into the comprehensive psychological intervention group (group A,n=40)and the cognitive therapy group (group B,n=40).Before and after 8-week treatment,the influence on cognitive function were measured with WAIS-RC,WMS,WCST and TESS were compared between two groups.Results After eight weeks,the intelligence quotient,remembrance quotient ,sustained errors and random errors in group A (110.52±18.03,110.78±1.15.42,15.48±9.82,17.46±13.28) were higher than that in group B (96.64±18.26,102.23±13.4,20.35±11.47,24.92±13.71).The difference between the two groups was found in improving cognitive function in schizophrenia patients(P<0.05).Conclusion Cognitive therapy could improve cognitive function in schizophrenia,but comprehensive psychological intervention would do much better.
2.Study on the Effects of Ambient Air Pollution on Respiratory Disease and Symptoms Among School-Age Children in Beijing
Shaoli WANG ; Xinbiao GUO ; Jinliang ZHANG
Journal of Environment and Health 1993;0(01):-
Objective To understand the effects of ambient air pollution on respiratory disease and symptoms among school-age children in Beijing and provide scientific basis for control and prevention of ambient air pollution in order to enhance the chidren's health. Methods The investigation was carried out in 3 areas(A, B, C) with ambient air pollution in different degrees of by different air pollution source in Beijing based on the data of environmental monitoring. 3 primary schools were selected in each investigation area. There were 5 749 observed pupils from 3 area in total. Investigation on respiratory health was performed by using the standard questionaire among pupils of Grade 1-Grade 5 in each school sampled by claster sampling method. Results The prevalences of respiratory disease and symptoms among children in A area with better ambient air quality were significantly lower than those in B area and C area with heavy ambient air pollution(P
3.The extraction of foreign body in nasal sinus and bases of skull: craniotomy or not?.
Zheng FU ; Shaoli WANG ; Yuliang ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(12):1127-1129
Craniotomy
;
Foreign Bodies
;
surgery
;
Humans
;
Paranasal Sinuses
;
pathology
;
Skull
;
pathology
4.Evaluation of different cleaning methods on the cleaning effect of gastroscope
Xiaoning YUAN ; Shaoli WANG ; Xinmao ZHAO ; Yongzhong NING ; Xuesong YANG
Chinese Journal of Practical Nursing 2008;24(15):64-65
Objective This study compared the cleaning effect of gastroscope by different cleaning mehtods and discuss practical and reliable evaluation method for the cleaning degree of gastroscope.Methods Three cleaning methods were selected and used in the cleaning of gastroscope.The Endocheck lumen was used to examine the cleaning degree of gastroscope and the effects of different methods were compared. Results The qualification rate by using ordinary cleaning method was 50.0%and it reached 60.0%and 73.3%by elevation of polyenzyme concentration and adding bedside pre-washing.which Was statistically different from that by using ordinary cleaning method(P<0.05).Conclusions Bedside pre-washing could increase the cleaning degree of gastroscope;Endocheck lumen could be regarded as an evaluation method for the cleaning degree of gastroscope.
5.Value of pretreatment 18F-FDG PET/CT uptake heterogeneity for early prediction of response to targeted therapy in patients with HER2 positive metastatic breast cancer
Bingxin GU ; Yizhao XIE ; Biyun WANG ; Shaoli SONG ; Zhongyi YANG
Chinese Journal of Nuclear Medicine and Molecular Imaging 2021;41(2):76-81
Objective:To evaluate the value of pretreatment 18F-fluorodeoxyglucose (FDG) PET/CT-based heterogeneity for early prediction of targeted therapy outcome in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer. Methods:From May 2012 to April 2018, 29 patients (all females, median age: 52 (32-69) years) who had HER2 positive metastatic breast cancer and underwent pretreatment 18F-FDG PET/CT in Fudan University Shanghai Cancer Center were retrospectively enrolled. All patients received trastuzumab as first-line treatment and were followed up for 6-87 (median time: 35) months. The relations between clinicopathologic parameters or PET/CT-based parameters and progression-free survival (PFS)/overall survival (OS) were analyzed with Cox univariate analysis. The parameters with P≤0.01 were further analyzed with Cox multivariate analysis. Optimal cut-off values were determined by time-dependent receiver operating characteristic (ROC) curve analysis. The survival analyses were estimated by Kaplan-Meier method and log-rank test. Results:The median OS of the 29 patients was 30 (6-83) months, and the median PFS was 10 (2-29) months. The PET/CT-based heterogeneity index(HI), including the maximum standardized uptake value (SUV max) ratio (SUV max-R; hazard ratio ( HR)=8.6, 95% CI: 2.7-27.8, P<0.001), the mean standardized uptake value (SUV mean)-2.5 (the cut-off value of standardized uptake value (SUV)=2.5) ratio (SUV mean-2.5-R; HR=2.6, 95% CI: 1.2-5.9, P=0.020), the metabolic tumor volume(MTV)-2.5 ratio(MTV-2.5-R; HR=2.4, 95% CI: 1.1-5.2, P=0.030), and the total lesion glycolysis(TLG)-2.5 ratio(TLG-2.5-R; HR=3.2, 95% CI: 1.4-7.4, P=0.008) of the lesion with the highest SUV max to that with the lowest SUV max, were significantly associated with PFS. None of the parameters was significantly associated with OS (all P>0.05). Multivariate analysis showed that the SUV max-R was the only independent predictor for PFS ( HR=6.8, 95% CI: 1.8-26.1, P<0.01). Area under the ROC curve for SUV max-R was 0.747. With a cut-off value of 1.8, SUV max-R could effectively distinguish the benefit from non-benefit population treated with trastuzumab (15.0 vs 7.0 months; χ2=18.68, P<0.01). Conclusion:Pretreatment 18F-FDG PET/CT-based HI has potential value for early prediction of first-line trastuzumab treatment outcome in patients with HER2 positive metastatic breast cancer.
6.Clinical features of microscopic colitis in the elderly and short-term effect of mesalamine on microscopic colitis
Junfeng ZHANG ; Na LIU ; Zibai WEI ; Shaoli WANG
Chinese Journal of Geriatrics 2013;32(7):748-750
Objective To investigate clinical features of microscopic colitis (MC) in the elderly and short-term effect of mesalamine on MC.Methods Totally 116 elderly patients with MC in our hospital were recruited from January 2011 to December 2011.Clinical manifestations,use of MC related drugs (MCRDs),pathological classifications and short-term effect of mesalazine were collected and analyzed.Results MC patients accounted for 27.6 % in elderly patients with chronic diarrhea,who presented with mild to middle watery or mucous stool,and only 1.7% of MC patients accompanied with severe stomach pain.Collagenous colitis (CC) and lymphocytic enteritis (LC) accounted for 31.9% and 68.1%,respectively in MC patients and 50% of them had MCRDs taking history.There was a significant difference in short-term effective rate between CC group and LC group at 4 weeks after mesalazine treatment (64.9% vs.84.8%,x2 =5.929,P=0.015).The effective rate was significantly related with the relief of pathology in LC group (x2 =5.896,P=0.015).The relapse rate had no significant difference between CC group and LC group at 8 weeks after withdrawal of mesalazine treatment (45.8% vs.34.3 %,P =0.317).Conclusions MC may be one of the main reasons leading to chronic diarrhea in the elderly.Mesalazine has a better effect for the short-term treatment of MC in the elderly,but the long-term maintenance therapy still needs further study.
7.Effect of comprehensive intervention on antimicrobial use and incidence of healthcare-associated infection in sports medicine department
Xiaoning YUAN ; Lin REN ; Xinmao ZHAO ; Shaoli WANG ; Xuesong YANG
Chinese Journal of Infection Control 2015;(3):196-198
Objective To explore the effect of comprehensive intervention measure on antimicrobial use and incidence of healthcare-associated infection(HAI)in patients in sports medicine department.Methods Antimicrobial use and incidence of HAI in hospitalized patients in the surgical departments (sports medicine department and other surgical departments)of a hospital between January 2006 and December 2010 were analyzed retrospectively(before intervention),from January 2011, comprehensive intervention based on clinical-centered multi-department cooperation was adopted by sports medicine depart-ment,the other surgical departments over the same period were not comprehensively intervened;antimicrobial use and inci-dence of HAI in patients in surgical departments between January 2012 and December 2013 were monitored prospectively (after intervention ),effectiveness of intervention was evaluated.Results Antimicrobial use and incidence of HAI in pa-tients in sports medicine department after intervention were both lower than before intervention (55.75% vs 95.26%,χ2=753.42;0.10% vs 0.32% ,χ2 =15.13,both P <0.01).Antimicrobial use in patients in other surgical departments after intervention was lower than that before intervention(65.63% vs 73.79% ,χ2 =251.57,P <0.01 );incidence of HAI was higher than that before intervention(0.55% vs 0.42% ,χ2 =19.04,P <0.01).Conclusion Comprehensive in-tervention measure based on clinical-centered multi-department cooperation is safe and effective,it can reduce antimicrobial use and incidence of HAI in patients in sports medicine department.
8.Performance verification of lactate dehydrogenase in Johnson Vitros 5 .1 FS biochemical analyzer
Lixin WANG ; Pei YANG ; Qin YIN ; Kaichun CHEN ; Shaoli DENG
International Journal of Laboratory Medicine 2016;37(17):2382-2383,2386
Objective To study the performance verification of lactate dehydrogenase(LDH) in the Johnson Vitros 5 .1 FS bio‐chemical analyzer .Methods According to CLSI instrumentation evaluation standard and referring to the validation scheme provided by the Johnson company ,the precision ,accuracy ,linear range of LDH ,maximum dilution degree ,biological reference range were verified .Results The LDH intra‐batch and inter‐batch precision experiments were≤3 .30% ;the accuracy experiment≤4 .00% ;the determination coefficient of the linear experiment was 0 .997 2 ;the LDH maximum dilution degree was 8 times with saline solution dilution;the biological reference range experiment verified that the reference range 313-618 U/L provided by the VITROS Meth‐odology Manual could be quote .Conclusion The performance verification of LDH detected by the Johnson Vitros 5 .1 FS biochemi‐cal analyzer basically conforms to the requirements of the quality objectives and manufacturer′s instructions ,and meets the needs of clinical test .
9.Analysis on Distribution and Antibacterial Resistance of Nosocomial Infection Pathogens of ICU Inpatients in a Hospital
Shaoli WANG ; Xinmao ZHAO ; Yongzhong NING ; Xi ZHU ; Xuesong YANG
Chinese Journal of Nosocomiology 2009;0(21):-
OBJECTIVE To investigate the distribution and drug resistance of nosocomial infection pathogens.METHODS The data of pathogen′s origin and antibacterial resistance of Intensive Care Unit(ICU) inpatients from Apr 2008 to Mar 2009 in a Hospital were analyzed.RESULTS There were 226 strains pathogens isolated from 116 nosocomial infection cases,from which the Gram-negative bacteria were predominate(63.27%).The resistance rates of Acinetobacter baumannii was the highest in Gram-negative bacteria,more than 70% isolates resistant to almost antibacterial.The main Gram-positive bacteria were Staphylococcus aureus,and the rate of meticillin-resistant S.aureus(MRSA) was 41.3%.All S.aureus were sensitive to vancomycin and Linezolid.CONCLUSIONS To control the antibacterial resistance of pathogens and decrease the nosocomial infection,it is important to strengthen the appropriate use of antibiotics.
10.A Case of Nosocomial Infection Incident in a Hospital:An Epidemiology Investigation
Shaoli WANG ; Xinmao ZHAO ; Yuling SHEN ; Xiaoning YUAN ; Xuesong YANG
Chinese Journal of Nosocomiology 2009;0(23):-
OBJECTIVE To investigate a case of nosocomial infection incident in a hospital,analyze the reasons and put forward preventive measures.METHODS Investigation was carried out on the related people and environment in the department where the incident occurred.Analysis was made on the reasons and processing.RESULTS The nosocomial infection incident was caused by Norovirus;fecal-oral transmission and contact transmission were 2 main pathways of Norovirus.There were 7 persons who had been contaminated by Norovirus,included 5 old inpatients,1 doctor and 1 nurse.CONCLUSIONS Many people should work to prevent and control the infections in hospital,such as doctors,nurses,inpatients,hospital works etc.Hand-washing and disinfection isolation should be enhanced among the hospital staffs in the normal works.