Acute lymphoblastic leukemia has been divided into four immunological types with anti-pan-T, anti-CALLA, anti-HLA monoclonal antibo-dies and Es rosctte forming test and SmIg surface analysis. The results of immunolgical typing of 19 ALL cases reveal that the majority of those cases is C-ALL type and the B-ALL type appears rarely, the majority of T-ALL appears in boys.

The phosphatidylinositide-3-kinase(PI3K)/ protein kinase B(Akt)/ mammalian target of rapamycin(mTOR)pathway is recognized to have an important role in the development and progression of colo-rectal cancer(CRC). The most extensively characterized downstream targets of mTORC1 are ribosomal protein S6 kinase 1(p70S6K1)and eukaryotic translation initiation factor(eIF)4E-binding protein 1(4EBP1),both of which are crucial to the regulation of protein synthesis. The abnormal expression of p70S6K1 and 4EBP1 in CRC has become the focus of attention.

Scutellarin (SC),a botanical extract,possesses a variety of suppressing free radical generation,anti-inflammatory,cardioprotection and anti-virus activity.Recently,many studies show that SC has inhibitory effects on the growth of many tumors and is a kind of potential anti-tumor drug.Its anti-tumor mechanisms mainly include inducing apoptosis,arresting cell cycle,enhancing the adhesion between cells,inhibiting tumor invasion,reversing multidrug resistance,anti-angiogenesis and so on.

Recentyearshavewitnessedmuchprogressinbothbasicresearchandclinicaltrialsregar-ding cancer immunotherapy with chimeric antigen receptor (CAR)-engineered T cells.CAR combine the varia-ble regions of a specific monoclonal antibody (scFv)with the CD3ζendodomain.The extracellular domain of CAR-engineered T cells directly dock to the tumor-associated antigen (TAA).When T cells bind to target anti-gens,they mediated redirected cytotoxicity and secrete a series of cytokines such as Perforin,Granzyme,Inter-feron-γ(IFN-γ)and Tumor necrosis factor-α(TNF-α),which would eventually lead to the necrosis of tumor cells.Although the antitumor response of the CAR-engineered T cells is considered as successful and surpri-sing,it should be noted that some safety issues have been observed in other several basic researches and clinical trials.This overview focuses upon the utility and safety of the CAR-engineered T cells.

The inhibition of bronchoalveolar surfactant function by endotoxic rat plasma was compared with that by normal rat plasma with M-8601 film balance. The results showed that endotoxic rat plasma significantly inhibited surfactant function of bronchoalveolar lavage (BAL). In the same protein concentration, the inhibition effects caused by endotoxic rat plasma were comparable with those by normal rat plasma. There were no changes of the inhibition effects after incubation of BAL with either endotoxic or normal plasma at 37℃ for 30min. These results suggest that the inhibition of surfactant function by the leakage of plasma in endotoxic lung injury is mainly due to protein components.

Objective Recently a lot of studies have shown carbon nanoparticles can protect parathyroid, however, there is no application in outpatient thyroid operation. The article was to investigate the influence of carbon nanoparticles suspension ( CNS) in?jection on the operation and prognosis of outpatient thyroid microcarcinoma(TMC) surgery. Methods Retrospective analysis was conducted on the clinical data of 65 patients who underwent outpatient TMC surgery from January to June in 2015 in our hospital. The patients were divided into 2 groups:33 patients in trial group were injected with CNS, and the other 32 patients in control group under?went conventional surgery. Comparison was made in operation information, pathologic data, postoperative complications, postoperative hospital stay as well as C?reactive protein(CRP) and blood calcium of the first day after operation between the two groups. Results The average number of VI region lymph nodes in trial group(8.21±2.08)was significantly higher than that of control group(P=0.004). Removal of 5 parathyroid glands for mistake was detected in control group, but no removal of parathyroid gland was detected in trial group, showing significant difference (P=0.028). 3 patients in control group had numbness in skin, while none in trial group. The hospital stay of trial group was lowered significantly in comparison to that of control group([31.09±6.62] vs [35.75±7.37], P=0.009). The average C?reactive protein ( CRP ) of the first day after operation in trial group was much lower that of control group([7.17±5.20] vs [9.87±5.60] mg/L, P=0.048). The average blood calcium of the first day in trial group was much higher than that of control group ([2.07±0.17] vs [1.98±0.20] mmol/L, P=0.036). Conclusion Outpatient TMC surgery injected with carbon nanoparticles sus?pension can protect parathyroid gland function, reduce surgical stress and accelerate recovery.

The incidence of thyroid cancer is increasing recently, and differentiated thyroid cancer accounts for more than 90% of all thyroid malignancies.Although the degree of malignancy of thyroid cancer is lower and prognosis is better, but there is pos-sibility to relapse and metastasis.The concept of precision medicine has paid more and more attention by many surgeons.This paper reviews how to get perfect diagnosis and therapy of differentiated thyroid cancer to reduce risk of relapse and metastasis by application of precision medicine.

Objective To analyze the different procedures and their clinical effects on treatment for pan-creatic pseudocyst( PPC) .Methods The management and outcome of 78 patients with PPC from Jan.2002 to Jun.2012 were retrospectively analyzed.Results 20 patients underwent conservative treatment and the pseudo-cysts absorbed spontaneously during follow up.Invasive procedures were performed in 58 cases, including percu-taneous catheter drainage in 3 cases with 1 postoperative pancreatic leakage and 1 postoperative pancreatic ab-scess;PPC external drainage in 5 cases with 2 postoperative pancreatic leakage and 1 postoperative bleeding;pancreatic pseudocyst stomach anastomosis in 15 cases with 1 postoperative gastrointestinal bleeding;Roux-en-Y cystjejunostomy in 29 cases with 2 gastrointestinal bleeding;cystduodenostomy in 2 cases;pancreatic pseudocyst excision in 2 cases with 1 postoperative pancreatic leakage; and laparoscopic cystogastrostomy in 2 cases.Con-clusions At present, there are various treatment options for pancreatic pseudocyst and it is necessary to choose treatment strategy according to patient's condition.Internal drainage is still the primary option of surgical proce-dures in treatment for pancreatic pseudocyst.

Objective:To study the effect of a three-in-one counseling model on mental health of medical students Method: A three-in-one counseling model composed of mental health education, group counseling and individual counseling was applied to 150 freshmen of a medical school (study group) Other 150 freshmen were collected as control The intervention lasted for 1 year The effect was assessed with EPQ, SCL-90, GWB (gross well being), SCCS (self-consistency and congruence scale), SAD (social avoidance and distress scale) and LESU (life events scale of undergraduates) at the baseline, in the middle and at the end of the study Result: After intervention, the study group had lower score in psychoticism of EPQ (46 3?7 5) than control group (50 7?11 9), and higher score in flexibility (48 9?5 6) than control (46 8?5 9) The total score and many subscores of SCL-90 decreased in study group While the scores of social avoidance and distress increased in control group Conclusion: The three-in-one counseling model has effect on balancing personality, reducing psychosomatic symptoms, facilitating self consistency and improving social interaction of medical students

Objective: To observe the curative effectiveness of laser therapy in 114 cases(120 eyes) posterior capsular opacity after intraocular lenses implantation in children.Methods: When the after-cataract appear,laser therapy should be performed as soon as possible.Under conscious condition,enable the children to cooperate maximally;short effect and mild mydriatic to dilate the pupil,a 4 mm diameter transparent zone in central was made allowing for satisfactory visual performance;Began with low energy(0.4 MJ) and increased progressively according to individual reaction,total energy was 20-30 MJ every time. Results: All the eyes' visual acuity recovered to the best level prior to posterior capsular(opacity) occurrence,corrected visual acuity 0.1-0.4 in 58 eyes,0.5-0.8 in 54 eyes,1.0 in 8 eyes.90 percent were succeed in one laser shot,no intraocular lenses damage was found in slit lamp microscope examination.Conclusion: laser can resect the posterior capsular opacity effectively,improve the visual function of the affected eye.Assisted with amblyopia treatment, laser capsulotomy play an important role in visual function reconstruction in these patients.