1.Revision surgery of lumbar interbody fusion with cage
Shaodong ZHANG ; Tiansi TANG ; Xiaotao WU
Chinese Journal of Orthopaedics 1996;0(09):-
Objective To evaluate the methods and results of revision surgery for posterior lumbar cage interbody fusion (cage-PLIF) with postoperative complications, and to analyse the surgical techniques for prevention of these complications. Methods From October 1996 to December 2002, 21 patients with postoperative complications of cage-PLIF underwent reoperations. There were 11 males and 10 females with an average of 43.4 years. The interval between primary and revision surgery ranged from 6 days to 1.5 years with an average of 0.6 year. 16 patients suffering from lumbar disc herniation were treated with the discecto-my and single uninstrumented cage fusion, 5 patients of lumbar spondylolisthesis were treated with cage-PLIF and pedicle screw instrumentation. The complications included cage displacement backward in 20 patients, forward in 1,and cage subsidence in 9 as well. 15 patients complained of low back pain wors-ening or leg radicular pain, of which 4 had intermittent claudication and 10 had leg numbness or weakness during rehabilitation. Revision surgery included re-implantation of the cage filled with iliac crest bone chips in 11 patients, iliac bone autograft after removal of original cages in 7 and decompression of involved nerve root witbout removal of migrated cage because of technical difficulty. Pedicle screw fixations were used in 12 and the intertransverse fusion both with autograft and allograft was added in 7. Results The mean follow-up was 14.2 months (ranged, 7 to 36 months). The cages presented slight retro-displacement in 4 patients shortly after reoperation, without involvement into spinal canal during the subsequent follow-up. Bony fusion occurred in 13 patients, and the pseudarthrosis in 3 patients without further migration of cages. The clinical symptoms relieved in 5 patients, improved in 9, no any change in 6, and worsened in 1. However, low back pain remained in 8 patients, and dysuria in 1 patiant at the last follow-up. Conclusion The results of revi-sion surgery are not satisfactory according to this study, the surgical treatments should be performed as soon as possible if conservative treatments is ineffective. The correct surgical indication and proper technical are the key of prevention of the postoperative complications.
2.Interleukin 17 level changes in different stages of Coxsackie virus-induced myocarditis in mice
Song LIN ; Weifeng WU ; Yanlan HUANG ; Gong LI ; Shaodong TANG
Chinese Journal of Microbiology and Immunology 2009;29(8):727-731
lso.This result suggested that Th17 subset is differentiated in chronic stage of viral myocarditis.
3.Change and significance of serum inflammatory cytokines and pulmonary surface proteins in respiratory failure of full-term infants
Chong CHEN ; Ming CHI ; Shaodong HUA ; Jia CHEN ; Ling TANG ; Zhichun FENG
Chinese Journal of Neonatology 2018;33(3):191-195
Objective To study the changes and significance of inflammatory cytokines and pulmonary surface protein (SP) level in respiratory failure of full-term infants.Method Prospectively selected 30 cases of term baby with respiratory failure requiring mechanical ventilation and pulmonary surfactant (PS) treatment in BaYi Children's Hospital from May 2016 to January 2017 as case group,while 30 cases of term baby with transient tachypnea or hypoglycemia were control group.Blood samples were collected at the first and third day of hospitalization.The interleukin-6 (IL-6),IL-10,and tumor necrosis factor-α (TNF-α) were detected by flow cytometry,serum SPs were detected by enzyme-linked immunosorbent assay method.The statistical analyses were conducted by SPSS 22.0 software.Result The levels of IL-6,IL-10,SP-A,SP-B and SP-C in the case group were significantly higher than those in the control group [IL-6:172.4 (58.4,668.4) ng/L vs.8.3 (5.7,11.2) ng/L,IL-10:10.2 (5.9,31.5) ng/L vs.4.7 (3.6,7.1) ng/L,SP-A:6.94 (2.37,29.64) μg/L vs.0.56 (0.50,0.64) μg/L,SP-B:4.36 (1.99,5.25)μg/L vs.1.44 (1.25,1.79) μg/L,SP-C:0.87 (0.19,2.66) μg/L vs.0.14 (0.10,0.16) μg/L,P <0.05].After exogenous PS treatment,serum SP-A,SP-B,SP-C,IL-6 and IL-10 levels in the surviving group were significantly lower comparing with the first day (P < 0.05).The IL-6,SP-A and SP-C levels in the first day death group were significantly higher than those in survival group(P < 0.05).Conclusion Inrespiratory failure of full-term infants,serum IL-6 levels are consistent with the SP-A and SP-C levels,and a sustained increase may serve as a potential early biomarker for disease progression.
4.Application strategy of the"You Gu Wu Yun"theory to reduce the toxicity of traditional Chinese medicine from the perspective of"traditional Chinese medicine state"
Shijie QIAO ; Zongchen WEI ; Ziyao CAI ; Chao FU ; Shunan LI ; Zhanglin WANG ; Liqing HUANG ; Kang TONG ; Wen TANG ; Zhibin WANG ; Hairui HAN ; Duoduo LIN ; Shaodong ZHANG ; Huangwei LEI ; Yang WANG ; Candong LI
Journal of Beijing University of Traditional Chinese Medicine 2024;47(11):1506-1511
Based on the"You Gu Wu Yun"theory in traditional Chinese medicine(TCM),this paper believes that"Gu"in"You Gu Wu Yun"is extended to"state"from the perspective of"TCM state".In order to avoid the adverse reactions of TCM,the macro,meso,and micro three views should be used together,and macro,meso,and micro parameters should be integrated.We should also carefully identify the physiological characteristics,pathological characteristics,constitution,syndrome,and disease of human body by combining qualitative and quantitative method,highlighting the relationship between the prescription and the"state".The correspondence between prescription and the"state"will reduce the risk of adverse reactions of TCM.In this paper,we hope to focus on the guiding role of the"You Gu Wu Yun"theory in TCM research,to give full play to the characteristics and advantages of TCM,and to dialectically treat the role of TCM.
5.New interpretation of the theoretical connotation of the correspondence between prescription and syndrome from the longitudinal perspective of"traditional Chinese medicine state"
Shijie QIAO ; Chao FU ; Ziyao CAI ; Wen TANG ; Zhanglin WANG ; Zhibin WANG ; Kang TONG ; Mingzhu LI ; Hairui HAN ; Duoduo LIN ; Shaodong ZHANG ; Huangwei LEI ; Yang WANG ; Candong LI
Journal of Beijing University of Traditional Chinese Medicine 2024;47(6):760-764
The correspondence between prescription and syndrome is the advantage and characteristic of traditional Chinese medicine(TCM)treatment.However,the pathogenesis of clinical diseases is complex and the condition is changeable,and the clinical application is difficult to achieve the maximum effect under the existing cognition of the correspondence between prescription and syndrome.In this paper,the five categories of physiological characteristics,pathological characteristics,constitution,syndrome,and disease of the longitudinal classification of"TCM state"are introduced into the correspondence of prescription and syndrome.Under the vertical perspective of"TCM state",the theoretical connotation of the correspondence between prescription and syndrome is interpreted as"correspondence between prescription and state",namely correspondence of"prescription-physiological characteristics",correspondence of"prescription-pathological characteristics",correspondence of"prescription-constitution",correspondence of"prescription-syndrome",and correspondence of"prescription-disease".It is hoped to accurately grasp the corresponding connotation of the correspondence between prescription and syndrome,in order to deepen the clinical thinking mode of TCM.
6.Correlation between CT attenuation value of pulmonary artery thrombi and efficacy of interventional thrombolysis in patients with acute pulmonary embolism
Xiaonan SUN ; Zhongxiao LIU ; He ZHANG ; Xin TANG ; Shenman QIU ; Yankai MENG ; Lixiang XIE ; Shaodong LI ; Qingqiao ZHANG ; Kai XU
Chinese Journal of General Practitioners 2024;23(7):728-733
Objective:To analyze the relationship between CT attenuation value of pulmonary artery thrombi and the efficacy of interventional thrombolysis in patients with acute pulmonary embolism (APE).Methods:This was a single center cross-sectional study. The clinical and imaging data of 89 APE patients who underwent interventional thrombolysis in Affiliated Hospital of Xuzhou Medical University from January 2018 to December 2022, were retrospectively analyzed. All patients underwent CT pulmonary angiography (CTPA) before and after thrombolysis, the CT attenuation value of pulmonary artery thrombi and ratio of CT attenuation value of thrombi to left subscapularis muscle CT value were obtained; and the difference of Qanadli embolism index (ΔQ) before and after thrombolysis was calculated. According to the median ΔQ, patients were classified as good efficacy group (ΔQ>50%) and poor efficacy group (ΔQ≤50%). The clinical characteristics and quantitative parameters of CT were compared between the two groups, and the factors associated with efficacy of thrombolysis were analyzed with univariate and multivariate logistic regression. The correlation between CT attenuation value of pulmonary artery thrombi and ΔQ was analyzed by Spearman correlation analysis.Results:The CT attenuation value of thrombi and ratio of attenuation value of thrombi to left subscapularis muscle CT value showed significant difference between the two groups ( P<0.05). Multivariate analysis showed that compared with CT attenuation value of emboli≤53.47 HU, the value>53.47 HU might be associated with the good efficacy of thrombosysis ( OR=9.175, 95% CI: 0.937-89.846, P=0.057). There was a positive correlation between CT value of pulmonary artery thrombi and ΔQ ( r=0.365, P<0.001). Conclusion:The CT attenuation value of thrombi can predict the efficacy of interventional thrombolysis in APE patients, and patients with higher CT attenuation value would have a better treatment response.