1.Significance of serum cytokines concentrations and APACHE scores in evaluating the illness state for Critical patients
Hui ZENG ; Shao-Chuan RUAN ; Li-Hua CAI ; Dong-Xin JIANG ; Bing-Jun TAN ; Yu-Qing YANG ; Xiao-Mei YUAN ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To investigate the clinical significance of serum cytokines concentrations and A- PACHE scores in evaluating the illness state for critical trauma patients.Methods A clinical prospective self-control trial was performed,in which 36 patients admitted to ICU by SIRS were enrolled.Objects were divided into mild and severe trauma group according to APACHE score.The TNF-?and IL-6 concentrations were determined on the 1st, 3rd and 5th day of admission,the APACHE score were assessed at the same time.Statistic analysis was performed according to this group.Results The TNF-?concentrations decreased continuously in the following days while IL-6 decreased from the 7th day in the mild trauma group.In the severe trauma group the TNF-?and IL-6,APACHE score concentrations kept increasing.There was a significant difference of TNF-?and IL-6 concentrations between severe trauma and mild trauma group.Conclusion Dynamic measurement of TNF-?and IL-6 concentrations with APACHE score provide great help to evaluate the illness state and predict the prognosis.
Result Analysis
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