AIM: To study the role of polymorphonuclear neutrophile(PMN) in lipopolysaccharide (LPS)- induced acute lung injury (ALI) and the protective effect of interleukin - 10(IL - 10) on ALI. METHODS: LPS alone (100 ?g) or LPS+ IL-10 (l ug) was instilled intratracheally into rats. PMN numbers, protein content and malondialdehyde (MDA) content in bronchoalveolar lavage fluid (BALF) were measured. Histological change of lung was also observed. RESULTS: LPS increased significantly PMN numbers, protein content and MDA content in BALF. Histological finding shows PMN accumulation in lung. IL - 10+LPS reduced remarkably PMN numbers ,pro- tein content and MDA content in BALF than those caused by LPS. PMN decreasing was also identified by light microscopy. CONCLUSION: LPS instilled intratracheally causes PMN accumulation in lung and ALI, while IL - 10 could alleviate ALI through reducing PMN accumulation.

Fourteen cases of adrenal myelolipoma proved by surgery and pathology are reported. All cases were in the right. CT of 14 cases revealed sharply marginated suprarenal mass, usually round or oval. The CT number were less than-30 HU. Their radiolucency was equal to or greater than normal fat, the remainder were of round soft mass or multiseptated streak soft trssue CT appearance may represent pathologic findings. By evaluating location, as well as the lack of contrast enhancement in the fatty portion, it seems that a specific histologic diagnosis can be made preoperatively by CT. According to CT appearance in our series, all of 14 patients established the correct diagnosis before operation. It seems that CT is superior in the preoperative diagnosis of adrenal myelolipoma to u'trasound and conventional radiologic examination including intravenous urography and angiography The etiology and pathology of myelolipoma as well as the differential diagnosis of fatty tumor in the suprarenal area are also discussed.