Objective To investigate the clinical-pathologic and immunohistochemical features of gastrointestinal stromal tumors(GISTs). Methods All of patients with GISTs who underwent surgical treatment were studied by clinical pathology and immunohistochemistry. The expresstions of D117,CD34,vimentin,desmin,S-100 etc. were detected with SP method. The endoscopic characteristics were reviewed. Results A total of 15 patients was enrolled in the study,with 3 benign,5 borderline,and 7 malignant cases. The common symptoms included the gastrointestinal bleeding and abdominal pain,some had abdominal masses. Endoscopically,the gastric stromal tumors showed submucosal protuberant lesions. Eight tumors were located in fundus,four in body,two in antrum. The submucosal masses of 6 patients existed with ulcer on the surfaces. Histology revealed typical stromal tumor features with spindle,epithelioid,or mixed appearance. The tumor cells were arranged in whirling and pallisading. All cases were positive for CD117 and CD34,vimentin,but negative for desmin. The positive rate of S-100 was only 7.1%. Conclusions GISTs are the most frequent mesenchymal tumors. CD117,CD34 can be used to diagnose GISTs as immunomarker.