Objective To explore the clinical significance of rheumatoid factor (RF) in primary SjSgren's syndrome (pSS).Methods The clinical and laboratory data of 141 cases of hospitalized pSS patients from Wannan Medical College Affiliated Yijishan Hospital from 2006 to 2012 were analyzed retrospectively,and the clinical significance of RF was also analyzed.The data were analyzed using t-test and ~ test respectively.Results The positive rate of RF in pSS was 49％ (63/128),the rate of low-titer positive RF was 32％ (20/63),and the high-titer positive RF was 68％ (43/63).Patients with high-titer positive RF were more prone to suffer from parotidomegaly,arthritis and hematological system involvement.In terms of the results of laboratory examination,the following were more frequent,including positive anti-SSA antibody,the elevated IgG level,the decrease of platelet,the increase of erythrocyte sedimentation rate (ESR) and the increase of total globulin level.For the respect of clinical performance and laboratory examination between patients with low-titer positive RF and negative RF,no difference was found statistically.Conclusion pSS patients with high-titer positive RF are prone to have extraglandular organ involvement,and acute-phase reactants and antibody levels are relatively high.