Research of antibacterial effect, progress and actuality of application of metal-ion antibacterial agents of were reviewed in the present paper. Research of effect to health and development tendency of metal-ion antibacterial agents of in the future was discussed. Metal-ion antibacterial agents are made of mineral carrier and interim metal-ion or light catalytic agent of oxide or organic antibacterial agent composite, they are a kind of new type antibacterial agents showed some excellent properties and efficiency, they will play a more and more important role to protect environment and enhance human health in the future.