Objective To explore the property of brain functional networks and cognitive function changes in patients with frontal lobe low-grade gliomas (LGG).Methods 8 cases of suspected frontal lobe LGG patients were undergone with resting-fMRI scanning to analyze the small-world property of the LGG,meanwhile the LGG groups had Montreal (MoCA) cognitive score exam compared with the control group.Results The value of MoCA was 22.5 ± 1.5,21.8 ± 2.0,and 27.9 ± 2.1 respectively with statistical significance (P ＜ 0.05) in the LGG groups and the control groups.The LGG group cognitive score was significantly lower than that in the control group with statistical significance (P＜ 0.05).As to threshold,the two groups were consistent with the small world property.The LGG local efficiency was smaller than that of the controls,the postoperative small world properties (σ=2.49) were lower than that the pre-operative (σ =2.68),the largest brain function areas of preoperative information transmission were respectively the supramarginal gyrus,posterior cingulate,insula,and the postoperative being the precuneus,calcarine sulcus and superior frontal gyrus.The maximum cluster coefficient of the preoperative functional network were respectively the entorhinal cortex,transverse temporal gyrus and the calcarine sulcus,and postoperative were Wilson,transverse temporal gyri and occipital gyrus.Preoperative information transmission path was less than the postoperative,and the small world properties were positively correlated with MoCA.Conclusion LGG accompany by the changes of cognitive function,and with the small world network property preand post-operation.

The real-time in vivo measurement method has been urgently needed in the research of pharmacokinetics. In the present paper a new in vivo detection method based on fluorescence spectroscopy has been proposed and the monitoring system has been built which is used for pharmacokinetics studies in rats. The relationship between fluorescence intensity and concentration was obtained. By detecting the fluorescent dye Cypate in real-time in rats, the properties of the system have been validated by comparing with the fluorescence imaging system in vitro. The results showed that the system could be feasible for: (1) The linear regression equation of Cypate concentration in the range of 0.098-25 microg/ml is y = 73.249x + 130.97 (R2 = 0.9991 and P < 0.001). RSD of high, medium and low concentration is 1.23%, 6.29% and 13.48%, respectively, and the detecting sensitivity is 0.0981 g/ml; (2) The fluorescent dye concentration from the system is consistent (r = 0.9925) with the fluorescence imaging system in vitro. The fluorescent dye metabolism in rats can be well detected. It can be concluded that a new real-time in vivo detecting method in the paper can be used in pharmacokinetics research.
Animals ; Fluorescent Dyes ; pharmacokinetics ; Rats ; Spectrometry, Fluorescence ; methods ; Spectroscopy, Near-Infrared ; methods

In order to choose a fast and efficient real-time method in beta wave information extraction, we compared the result and the efficiency of the information separation of both fast Fourier transform (FFT) and wavelet transform of EEG beta band in the present paper. Our work provides the basis for the EEG data come from the real-time health assessment of 3DTV. We took the EEGs of 5 healthy volunteers before, after and during the process of watching 3DTV and meanwhile recorded the results. The trends of the relative energy and the time cost of two methods were compared by using both the FFT and wavelet packet transform (WPT) which was to extract the feature of EEG beta wave. It demonstrated that (1) Results of the two methods were consistent in the trends of watching 3DTV; (2) Results of the differences in two methods were consistent before and after watching 3DTV; (3) FFT took less time than the wavelet transform in the same case. It is concluded that the results of both FFT and Wavelet transform are consistent in feature extraction of EEG, and a fast method to work with the large quantities of EEG data obtained in the experiments can be offered in the future.
Algorithms ; Brain ; physiology ; Electroencephalography ; methods ; Fourier Analysis ; Humans ; Male ; Signal Processing, Computer-Assisted ; Television ; Wavelet Analysis ; Young Adult

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8