Objective To evaluate the effects of early rehabilitation on development of infants with cerebral injury in pefinatal period.Methods 84 high risk infants with cerebral injury in pefinatal period were divided into two groups.Infants in the control group were treated with conventional medicament and those in intervention group received physical,visual,aural and haptic stimuli combined with Vojta and Bobath approach in addition.Clinical data and Gesell Development Schedules of 1 year old were used to evaluate the effect.Results The incidence of improvement was 92.86% in the intervention group and 73.81% in the control group(P<0.05).The development quotient of Gesell Development Schedules were obviously higher in the intervention group than in the control group in all the functional areas(P<0.05).Conclusion The early rehabilitation can improve the cerebral development in high risk infants with cerebral injury in pefinatal period.