Objective To analyze the clinical characteristics and treatment methods of recurrence hand,foot and mouth disease (HFMD).Methods The clinical data of 436 HFMD patients were retrospectively analyzed.The characteristics of clinical manifestations,laboratory tests were analyzed.Results There were a total of 211 patients,accounting for 48.4％,the recurrence age was 2 to 5 years old.All relapsed patients rash appeared in the hand,foot and mouth or buttocks,there were 104 cases of rash appeared in elbow and knee,9 cases appeared in the torso.The recurrence patients proned to occur respiratory system,digestive system,cardiovascular system and nervous system complications.Respiratory complications were the most common,accounting for about 76.4％,followed by the digestive system,accounting for 18.5％.The distribution of relapse in children with time to recurrence and recurrence in-terval analysis found mainly in April to June,a total of 251 patients,the total relapse proportion was 57.6％ ;time in-terval was more common between 3 months to 12 months,a total of 326 cases of recurrence,accounting for 74.8％.Conclusion Clinical manifestations are not typical in recurrence HFMD patients,most are ordinary,less critically illpatients,it is easy to merge the respiratory system,digestive system complications.Early detection and diagnosis is the key to the treatment.