Objective To investigate the feasible safty of the subtotal thyroidectomy on the condition that hyperthroidism is accompanied with cardiothyotoxicosis. Methods In 138 hyperthroidism cases accompanied with cardiothrotoxicosis, the operation tolerance was evaluated preoperatively with a dagrous index of hyperthroidism accompanied cardiothrotoxicosis for operation. These patients were monitored and the dangerous factors were treated preoperatively, to make the operation safely. Results The cure rate that hyperthyroidism with subtotal thyroidectomy was 100%. The cardiothrotoxicosis cure rate was 89.2%. The cardiac insufficiency and operative complication didn't occur in any patient. Conclusions Hyperthroidism accompanied with caridiothrotoxicosis isn't of intraindaction to subtotal thyroidectomy. The operation is safe and effective after controlled the dangerous index.

Objective　 To investigate the profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis (NPC) induced by N,N'dinitrosopi perazine (DNP) and examined histolofically. Methods Nasopharyngeal carcinomas o f rats were induced by DNP and examined histologically. PCR-ELISA and nested R T -PCR were used to assay telomerase and telomerase RNA expression at different s tages in the nasopharyngeal tissues of rats. Results　 During the carcinogenesis p rocess, telomerase activity increased along with the formation of a nasopharynge al carcinoma. Telomerase expression was positively related with nasopharyngeal c arcinogenesis. Telomerase RNA expression was present and did not change during t he NPC process. Expression of telomease RNA was earlier than telomerase activat ion. Telomerase activation and telomerase RNA expressin were also detected in th e pre-cancerous nasopharyngeal lesions. Conclusion　 Telomerase activation may p articipate in the onset and progression of NPC, and is an early step in NPC.