Objective To explore the clinical effect of ozone combined with nifuratel nystatin vaginal soft capsules on the treatment of vaginitis, and to provide the basis for clinical application. Methods 204 patients with vaginitis in our hospital from January 2013 to December 2016 were divided into the observation group (114 cases) and the control group (90 cases) according to the different treatment methods. The control group was treated with nifuratel nystatin vaginal soft capsules, and the observation group was treated with ozone combined with nifuratel nystatin vaginal soft capsules. The clinical efficacy, symptom relief time and adverse reaction were compared between the two groups. Results After treatment, the total effective rate in the observation was 97.37%, which was significantly higher than 85.56% in the control group(P<0.05). The rapid remission rate of the clinical symptoms in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The effect is significant that ozone combined with nifuratel nystatin vaginal soft capsules is used on the treatment of vaginitis, which can quickly relieve symptoms, and will not significantly increase the adverse reactions, is worthy of application.

Objective To investigate the expression of MnSOD and E-cadhefin in nasopharyngeal carcinoma(NPC) tissue and its relationship with clinicopathological features and prognosis. Methods The expression of MnSOD and E-cadherin were detected by immunohistochemistry method in 60 NPC patients. Results Of the whole group,lymph node positive group and lymph node negative group,the strong positive rate of MnSOD protein was 47% (28/60) ,49% (25/51 patients) and 33% (3/9) (x2 =0.76,P =0.382), respectively.The corresponding strong positive rate of E-cadherin protein was 47% (28/60) ,43% (22/51) and 78% (7/9) (x2 =3.69,P =0.047) ,respectively.The expression of MnSOD increased with T stage and N stage.The higher expression of MnSOD was significantly associated with the larger size of metastatic lymph node(r =0.46 ,P =0.002) ,more radioresistance and poorer prognosis,but not with the region of lymph node metastasis(r =0.223,P = 0.116).The lower expression of E-cadherin was closely relevant with higher N stage and the smaller region of lymph node metastasis(r =-0.33,P = 0.020),but not with T stage,lymph node size or radiosensitivity(r =-2.19,P=0.093;r=-0.07,P=0.623;r=-0.18,P=0.170).Multi variate analysis showed that MnSOD and E-canherin were independent prognostic factors (x2= 4.45,P = 0.035;x2 =5.12,P=0.024). Conclusions High expression of MnSOD may stimulate tumor growth and reduce radiosensitivity.High expression of E-cadherin may inhibit lymphatic metastasis,while has no rela tionship with tumor growth and invasion.MnSOD and E-cadherin could affect the prognosis of NPC patients.

Objective To evaluate the diagnostic value of plasma the soluble CD14 subtype(sCD14-ST,renamed as presepsin)in early diagnosis of sepsis patients with acute kidney injury(AKI).Methods A total of 110 patients with AKI in intensive care unit(ICU)of Wuhu Hospital Af-filiated to East China Normal University from January 2021 to December 2022 were prospectively se-lected.The patients were divided into AKI stage 1 group(n=34),AKI stage 2 group(n=36)and AKI stage 3 group(n=40)according to the staging criteria defined byKidney Disease:Improving Global Outcomes(KDIGO)in 2012,and 53 non-AKI patients in the same period were selected as the control group.The patients were further divided into non-sepsis group and sepsis group according to whether combined sepsis or not.Plasma Presepsin levels were recorded in all the patients.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of Presepsin inearly sepsis in AKI patients,and the optimal cutoff value was found using Jorden index.Results The level of Presepsin in the sepsis group was higher than that in non-sepsis group(P＜0.05).In non-sepsis patients,the level of Presepsin increased gradually with the aggravation of renal function injury(P＜0.05).The level of Presepsin in stage 3 AKI group was higher than that in non-AKI group(P＜0.01).ROC curve analysis results showed that thearea under the curve(AUC)of Presepsin level for diagnosing sepsis in stage 1 AKI group,stage 2 AKI group and stage 3 AKI group was smaller than that in non-AKI group(P＞0.05).Conclusion Presepsin can be used as a marker for early diagnosis of sepsis in AKI patients,but different thresholds should be used according to the severity of renal impairment.

Objective To evaluate the diagnostic value of plasma the soluble CD14 subtype(sCD14-ST,renamed as presepsin)in early diagnosis of sepsis patients with acute kidney injury(AKI).Methods A total of 110 patients with AKI in intensive care unit(ICU)of Wuhu Hospital Af-filiated to East China Normal University from January 2021 to December 2022 were prospectively se-lected.The patients were divided into AKI stage 1 group(n=34),AKI stage 2 group(n=36)and AKI stage 3 group(n=40)according to the staging criteria defined byKidney Disease:Improving Global Outcomes(KDIGO)in 2012,and 53 non-AKI patients in the same period were selected as the control group.The patients were further divided into non-sepsis group and sepsis group according to whether combined sepsis or not.Plasma Presepsin levels were recorded in all the patients.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of Presepsin inearly sepsis in AKI patients,and the optimal cutoff value was found using Jorden index.Results The level of Presepsin in the sepsis group was higher than that in non-sepsis group(P＜0.05).In non-sepsis patients,the level of Presepsin increased gradually with the aggravation of renal function injury(P＜0.05).The level of Presepsin in stage 3 AKI group was higher than that in non-AKI group(P＜0.01).ROC curve analysis results showed that thearea under the curve(AUC)of Presepsin level for diagnosing sepsis in stage 1 AKI group,stage 2 AKI group and stage 3 AKI group was smaller than that in non-AKI group(P＞0.05).Conclusion Presepsin can be used as a marker for early diagnosis of sepsis in AKI patients,but different thresholds should be used according to the severity of renal impairment.

Jiegengtang is a basic formula for treating sore throat and cough. By means of bibliometrics， this study conducted a textual research and analysis on the key information such as formula origin， decocting methods， and clinical application of Jiegengtang. After the research， it can be seen that Jiegengtang is firstly contained in Treatise on Febrile and Miscellaneous Disease， which is also known as Ganjietang， and it has been inherited and innovated by medical practitioners of various dynasties in later times. The origins of Chinese medicines in this formula is basically clear， Jiegeng is the dried roots of Platycodon grandiflorum， Gancao is the dried roots and rhizomes of Glycyrrhiza uralensis， the two medicines are selected raw products. The dosage is 27.60 g of Glycyrrhizae Radix et Rhizoma and 13.80 g of Platycodonis Radix， decocted with 600 mL of water to 200 mL， taken warmly after meals， twice a day， 100 mL for each time. In ancient times， Jiegengtang was mainly used for treating Shaoyin-heat invasion syndrome， with cough and sore throat as its core symptoms. In modern clinical practice， Jiegengtang is mainly used for respiratory diseases such as pharyngitis， esophagitis， tonsillitis and lung abscess， especially for pharyngitis and lung abscess with remarkable efficacy. This paper can provide literature reference basis for the modern clinical application and new drug development of Jiegengtang.

Jiegengtang is a basic formula for treating sore throat and cough. By means of bibliometrics， this study conducted a textual research and analysis on the key information such as formula origin， decocting methods， and clinical application of Jiegengtang. After the research， it can be seen that Jiegengtang is firstly contained in Treatise on Febrile and Miscellaneous Disease， which is also known as Ganjietang， and it has been inherited and innovated by medical practitioners of various dynasties in later times. The origins of Chinese medicines in this formula is basically clear， Jiegeng is the dried roots of Platycodon grandiflorum， Gancao is the dried roots and rhizomes of Glycyrrhiza uralensis， the two medicines are selected raw products. The dosage is 27.60 g of Glycyrrhizae Radix et Rhizoma and 13.80 g of Platycodonis Radix， decocted with 600 mL of water to 200 mL， taken warmly after meals， twice a day， 100 mL for each time. In ancient times， Jiegengtang was mainly used for treating Shaoyin-heat invasion syndrome， with cough and sore throat as its core symptoms. In modern clinical practice， Jiegengtang is mainly used for respiratory diseases such as pharyngitis， esophagitis， tonsillitis and lung abscess， especially for pharyngitis and lung abscess with remarkable efficacy. This paper can provide literature reference basis for the modern clinical application and new drug development of Jiegengtang.