Objective To investigate the effects of Xiaoke Wan on serum adiponectin levels in patients with type 2 diabetes metlitus. Methods A total of 60 2TDM patients with deficiency of both qi and yin syndrome were recruited into a control group and a treatment group randomly, 30 cases in each group. The treatment group was treated with Xiaoke Wan, and the control group was treated with glibenclamide. After 32 weeks, the changes of FPG, 2hPG, HbAIc, FINS, C-P, APN, HBCI,IRI and improvement of symptoms were compared between the two groups. Results Compared with glibenclamide, Xiaoke Wan can significantly improve the patients' symptoms, reduce the level of IRI (t=-1.590, P=-0.036), and increase serum APN (t=1.918, P=0.002). Conclusion Xiaoke Wan can significantly improve symptoms, reduce fasting blood glucose and 2 hour postprandial blood glucose, recover the secretion of adipouectin, decrease insulin resistance in 2TDM patients with deficiency of both qi and yin.

Alternating hemiplegia of childhood(AHC) is a hereditary disease characterized by hemiplegia spells,abnormal eye movements,dystonia and cognitive impairment.There are three phases of the disease.Each phase has its unique clinical symptoms:phase 1-abnormal eye movements and dystonia;phase 2-hemiplegia spells; phase 3-permanent cognitive impairment.The severity of cognitive impairment depends on the time of onset of hemiplegia spells:the earlier the onset is,the worse outcome will be.No effective treatment has been established.Thetreatments currently include:avoiding predisposing factors and taking drugs such as flunarizine to prevent hemiplegia attacks,in the inter-ictal stage;and sedation during hemiplegia attacks.According to the latest research,AHC is caused by the de novo mutation of gene ATP1A3.

Carcinoma, Squamous Cell ; metabolism ; pathology ; Esophageal Neoplasms ; metabolism ; pathology ; Humans ; Mitogen-Activated Protein Kinase Kinases ; metabolism ; NF-kappa B ; metabolism ; Prognosis ; STAT Transcription Factors ; metabolism ; Signal Transduction ; Transforming Growth Factor beta ; metabolism ; Wnt Proteins ; metabolism

?AlM:To evaluate the effect and safety of 1. 8mm coaxial microincision phacoemulsification - trabeculetomy with ultra-thin intraocular lens ( lOL ) implants for treating glaucoma complicated with cataract, and to compare with the traditional 3. 0mm small phacoemulsification-trabeculetomy with foldable lOL implantion.
?METHODS: ln this prospective study, 36 patients ( 36 eyes) with glaucoma and cataract in lnner Mongolia Autonomous Regian People’s Hospital were collected and randomly divided into 2 groups. For the small incision group: 18 cases ( 18 eyes ) underwent 3. 0mm coaxial incision phacoemulsification-trabeculetomy with foldable lOL implantion; ln th microincision group: 18 cases ( 18 eyes ) underwent 1. 8mm microincision phacoemulsification-trabeculetomy with ultra-thin lOL implantion. The two groups were recorded for 1wk, 1 and 3mo of visual acuity, corneal endothelial cell density, surgically induced astigmatism, intraocular pressure ( lOP ) , filtering bleb and complications. Pearson’s Chi-square test ande t-test were used to determine differences between the two groups.
?RESULTS:At 1wk postoperatively, visual acuity in the microincision group was better than that of small incision group, the difference was statistically significant ( P<0. 05). At 1 and 3mo, the difference in corrected visual acuity between the 2 groups had no significant difference (P>0. 05). At 1wk, 1 and 3mo, there was a significant different between the 2 groups in surgically induced astigmetism (P<0. 05). At 1wk postoperatively, there was a significant difference in corneal endothelial cells density between 2 groups (P<0. 05). But there were no significant difference at 1 and 3mo ( P > 0. 05 ). lOP reduced after surgy ( microincision group: 15. 26 ±3. 12mmHg, small incision group: 14. 57±2. 86mmHg), there was no significant difference between the 2 groups (P>0.05). There was no significant different between the 2 groups in blebs (P>0. 05). Neither iris injury, posterior capsule rupture nor anterior chamber bleeding complications was found in any groups.
?CONCLUSlON: TBy compared with traditional 3. 0mm coaxial small incision phacoemulsification -trabeculectomy with foldable lOL implantion, 1. 8mm microincision phacoemulsification-trabeculectomy withe ultra- thin lOL implantion can effectively reduce the astigmatism operation. This operation is safe, effective, convenient surgy for treating cataract and glaucoma.

Iodine is an essential micronutrient for pregnant women,which affects thyroid function of pregnant women and fetus,and thus influences the intellectual development of offspring.Severe iodine deficiency could lead to overt hypothyroidism and fetal cretinism.In the areas implemented the universal salt iodization (USI) program,mild to moderate iodine deficiency and iodine excess may coexist during pregnancy.Iodine deficiency could lead to hypothyroxinemia in pregnant women.Iodine more than adequate and iodine excess could increase the prevalence of subclinical hypothyroidism.The effect of iodine supplementation on thyroid function in pregnant women with mild to moderate iodine deficiency may result in different conclusion.Therefore,it is important to maintain optimal urinary iodine concentration to prevent thyroid dysfunction.

Objective] To sum up professor Shan Guangzhi's clinical experience for the treatment of bone metastasis of prostate cancer. [Method] From following professor Shan Guangzhi in the clinical practice and further studying his medical cases,summarizes his experience in the treatment of prostate cancer bone metastases,and sums up his academic thoughts for the treatment of the disease.[Result] Professor Shan Guangzhi thinks that deficiency of the kidney is the basic pathogenesis of bone metastases of prostate cancer,at the same time accompanied by spleen deficiency and qi-movement disturbance. To prostate cancer patients with bone metastases, pain is the most common symptom,the reason for it is that stagnation leading to pain and poor nutrition lead to pain. The treatment should focus on two aspects,both the inner treatment and the external treatment; the internal treatment regards invigorating Qi and tonifying the kidney as the basis,also pays attention to regulate spleen and stomach,dredges the body down;the external treatment regards promoting blood circulation to remove meridian obstruction as the rule,it can effectively relieve patients' pain,and cooperates with diet,as a whole to improve the quality of survival in patients. [Conclusion]Professor Shan Guangzhi's experience in the treatment of bone metastasis of prostate cancer has exact curative effect,worth learning and promotion.

Objective To investigate the prostate cancer diagnosis value of prostate-specific antigen (PSA) and free prostate-specific antigen (FPSA) change quantity before and after antibiotic treatment in patients with abnormal PSA.Methods Eighty-five patients with elevated PSA were selected,and the patients were treated with antibiotic (levofloxacin intravenous drip for 1 week).The PSA and FPSA levels were detected before and after treatment.All of the patients underwent prostate needle puncture biopsy.The relation between the PSA,FPSA change quantity before and after treatment and the puncture biopsy positive rate were analyzed.Results The PSA and FPSA levels after treatment were significantly lower than those before treatment:(5.82 ± 1.61) μ g/L vs.(7.71 ± 1.32) μ g/L and (0.80 ± 0.14) μ g/L vs.(0.98 ± 0.17) μ g/L,there were statistical differences (P ＜ 0.05).In 85 patients,10 cases were puncture biopsy positive.After treatment,no PSA change was in 8 cases,PSA decreased ＜ 10％ was in 27 cases,PSA decreased 10％-30％ in 24 cases,PSA decreased 31％-50％ was in 18 cases,and PSA decreased ＞ 50％ was in 8 eases,and puncture biopsy positive were 1 case (1/8),4 cases (14.8％,4/27),3 cases (12.5％,3/24),2 cases (2/18),0case,respectively.Conclusions The PSA can decrease after antibiotic treatment in patients with abnormal PSA,and small decrease of PSA does not mean that the risk of prostate cancer disappears,but the PSA decrease ＞ 50％ after antibiotic treatment means the risk of prostate cancer decreases,which may be closely observed.In patients unable to tolerate or unwilling to accept the prostate needle puncture biopsy,the PSA change quantity before and after antibiotic treatment can help to diagnose prostate cancer.

Objective To explore the effect of hepatocyte growth factor/scatter factor (HGF/SF) on apoptosis of colorectal cancer cells induced with curcumin. Methods MTT assay was used to evaluate the cytotoxicity of curcumin to colorectal cancer cells. Flow cytometry was used to detect the anti-apoptosis effect of HGF. Results Flow cytometry showed only 64 ?g/ml curcumin could play the proliferation-inhibiting role in Caco-2 cells leading to their apoptosis; at the same time, different concentrations of HGF could antagonize this inhibitory effect resulting in the decrease of apoptosis, but HGF worked without a concentration-dependent manner. The study on MAPK pathway showed that the protective effect of HGF on the apoptosis of Caco-2 cells was not influenced by inhibiting p42/p44 MAPK and p38 MAPK pathway. Conclusion HGF/SF antagonizes the apoptosis of Caco-2 cells induced with curcumin, but MAPK signaling pathway might not participate in this process.

Objective To evaluatethefunctions of an emergency pediatric observation unit(OU).Method The OU located in the Second Affdiated Hospital ＆Yuying Children'Hospital of Wenzhou Medical CoHege.a pediatric tertiary care teaching hospital.The records of all patients admitted to OU and the discharge diagnoses of all patients ofinpatient unit(IU)from January to December 2006 were retrospectively analyzed.[)d(Is ratios(OR) witll 95%C1 was used to show the advantages ofOU in SOme pedian4c diSOrders.Results There were45 beds in the OU,and 348 beds in tlle IU.111e number ofthe patients in OU per year WaS 42.5%compared to IU f5471 Vs.12 881).The average number of patients in OU per bed in one year WaS 122.which was 3 times as much as the average number of patients in IU admission per bed(122 vs.37).Totally 3879(70.9%)patients in OU were discharged and 1592(29.1%)were transferred.For the olmervation patie.ts,the IIIeaIl age Was 7 years old.with 65.6%under or equal to 2 years old.The 111ean le,ch of stay(IDS)in OU was95.7 hours.Respiratory disorders(2204/5471,40.3%)and gastrointestinal problems(960/5471,17.5%)were the most common disease in OU.Of the total admission(IU and ou),diagnoses with high OU utilization were croup(73/75,97.3%),poiflonin(277/,97.2%),flsthma(128/133,96.2%),fleiZl.1lwith high fever(274/365,75.1%),enteritis/dehydration(618/726,85.1%),seizure with 110 fever(274/365,75.1%)and acute respiratory infection(486/624.77.9%).The likelihood of an OU admifor these illness vells IU addlission(adjusted for subsequent need for IU admission)was poisonings OR 43.21(26.1,71.6),P<0.001;croup 15.7(8.3,29.7),P<0.001:asthma 0R 10.5(7.0,15.8),P<0.001;seizure with high fever OR 8.5(6.5,11.1),P<0.001;seizure with no fever2.6(2.2,3.1),P<0.001;acute respiratory infection 0R 1.0(0.9,1.1),P=O.591;enteritis/dehydration 1.0(0.9 1.1),P=0.919.Conclusions The emergency OU,characterized by large ac.commodation,fast circulation and high utilization rate of bed,plays an important role in observation,treatment and hospital admission of children,esoeeially infants and young children for common pediatric diseases.The emergency observation unit is also an alternative disposition for certain pediatric diseases.The extending construefion of OU in a childrenS hospital with big population of out-/in-patients is an effective way to the hospital resources.

Objective To explore the correlation of adipnectin with T2DM and its macrovascular complications. Methods The levels of serum adiponectin, plasma glucose, serum lipids, and fasting insulin were measured in normal subjects, type 2 diabetic patients and type 2 diabetic patients with macrovascular complications. Results (1) The serum adiponectin level was significantly lower in type 2 diabetic patients than in normal subjects, and was the lowest in type 2 diabetic patients with macrovascular complications. (2) Serum adiponetin level was negatively correlated with BMI,HOMA-IR, HbA_1c,TG and fasting insulin level. Conclusions The results suggest that lower serum adiponectin level may be related to macrovascular complications in type 2 diabetic patients.