Molecular Epidemiology ; trends

Antineoplastic Agents ; pharmacology ; therapeutic use ; Benzamides ; Clinical Trials, Phase II as Topic ; Drug Resistance, Neoplasm ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; Piperazines ; pharmacology ; therapeutic use ; Pyrimidines ; pharmacology ; therapeutic use

Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Neoplastic Stem Cells ; Pyrazoles ; Pyrimidines

Objective:To observe the effect of point-toward-point needling at points on the low back regions on residual back pain after percutaneous kyphoplasty (PKP),thoracolumbar function and quality of life (QOL) in patients with osteoporotic vertebral compression fracture (OVCF).Methods:A total of 72 patients with OVCF and residual back pain after PKP were included and allocated into a treatment group (n=36) and a control group (n=36) by the random number table.Cases in the control group received salmon calcitonin injection (miacalcic),for 1 mL each time,once a day,and oral intake of calcium carbonate D3 pill,600 mg each time,once a day,whereas cases in the treatment group received point-toward-point needling at points on the low back regions and electroacupuncture (EA) for 30 min each time,once a day and 6 times a week on the basis of the treatment in the control group.Treatment in both groups lasted for 2 weeks.Therapeutic efficacy indicators including visual analog scale (VAS),Oswestry disability index (ODI) and Barthel index (BI) were evaluated before and after treatment and at follow-up visit (1 month after treatment).Results:The total effective rate was 94.4％ and 88.9％ in the treatment group after treatment and at the follow-up visit,respectively,higher than 77.8％ and 69.4％ in the control group,and the between-group differences were statistically significant (both P＜0.05).After treatment and at the follow-up visit,the VAS and ODI scores decreased,and BI scores increased in both groups,and the intra-group differences were statistically significant (all P＜0.05).After treatment and at the follow-up visit,between-group differences of VAS,ODI and BI scores were statistically significant (all P＜0.05).Conclusion:On the basis of conventional medication treatment,point-toward-point needling at points on the low back regions has a good therapeutic effect in relieving residual back pain after PKP,improving thoracolumbar function and QOL,better than conventional medication treatment alone.

?AlM:To explore the use of rigid gas permeable ( RGP ) contact lens, and its clinical effect and safety in the treatment of adult high and special type ametropia.
? METHODS: Totally 110 cases ( 185 eyes ) of Ophthalmology Center fitting of RGP from January 2010 to December 2012 were retrospective analyzed. According to the refractive error types, patients were divided into high myopia astigmatism group( 49 cases, 92 eyes), 36 cases (64 eyes) of keratoconus group, special ametropia group (25 cases, 29 eyes). Corrected visual acuity differences, adverse reactions of different temporal acuity and conventional frame in the three group were observed after wearing RGP.
?RESULTS:After wearred RGP, corrected visual acuity of high myopic astigmatism group was 4. 94 ± 0. 16, keratoconus group was 4. 98±0. 15, and special ametropia group was 4. 87±0. 19; they were significantly better than wearing frame mirror 4. 86±0. 23, 4. 79±0. 22, 4. 61±0. 27 and the differences were statistically significant (P<0. 05). After 3 and 6mo of wearing RGP, patients eyesight after RGP was better than that of wearing frame glasses ( P<0. 05 ) . As the astigmatism group, keratoconus group, special ametropia group wearing RGP, visual acuity after distribution were obviously better than the case when wearing frame glasses(P<0. 05).
?CONCLUSlON: Wearring RGP can correct adult high and special type ametropia than ordinary frame glasses, which avoid the occurence of dry eye, foreign body sensation, and easy fatigue. lt is worthy of clinical application.

Objective To improve the prevention and control of hospital infection by real-time monitoring of hospital infection, identifying and early warning of hospital infection cases.Methods A hospital infection real-time monito-ring system was designed using computer network techniques according to the PDCA design concept in combination with practical experiences .Results The hospital infection real-time monitoring system could monitor the hospitalized patients and early warn the suspected patients.The system maintenance technicians and medical staff participated in the diagnosis of hospital infection through the information interaction platform and a complete hospital infection management network system was thus formed.Conclusion Hospital infection management and hospital infection monitoring are improved through the highly effective early warning and clinical intervention-feedback mechanism , thus a novel model is established for the prevention and control of hospital infection.

One hundred and thirty cases of simple obesity were treated by acupuncture plus auricular point sticking, after a course of treatments, 49 cases got marked effect, 73 cases got effect and 8 cases got no effect, the total effective rate was 93.8%, especially the patients with severe obesity got the best effect.

Follicular lymphoma (FL) is a type of B lymphocytic non-Hodgkin lymphoma.Clinically,FL presents with long course,indolent behavior,and is characterized by prompt response to initial therapy but almost invariably subsequent relapses.It is considered incurable with conventional therapies.Appropriate treatment strategies are critical for survival.Recently,several drugs such as rituximab,and bendamustine have been approved for FL treatment.Very promising novel agents like ofatumumab,epratuzumab,lenalidomide,bortezomib and ABT-263 are now under investigation in clinical trials and will provide more choices for FL therapy.

Objective To explore the significance of the changes of high density lipoprotein cholesterol (HDL-C) and high sensitivity C reactive protein (hs-CRP) in coronary heart disease patients combined with type 2 diabetes mellitus,and analyze the relationship between HDL-C and hs-CRP.Methods Two hundred and ten elder patients were selected.The patients were divided into simple coronary heart disease group (A group,70 cases),coronary heart disease combined with type 2 diabetes mellitus group (B group,71 cases),and simple type 2 diabetes mellitus group (C group,69 cases) according to the pathogenetic condition.Meanwhile 50 healthy controls were selected as control group (D group).The levels of HDL-C and hs-CRP were measured,and correlation analysis used Pearson linear correlation.Results The levels of HDL-C in A,B and C group were significantly lower than those in D group:(1.98 ± 0.47),(0.99 ± 0.31) and (1.27 ± 0.44) mmol/L vs.(2.18 ± 0.42) mmol/L,and there were statistical differences (P ＜ 0.05 or ＜0.01);the level of HDL-C in B group was significantly lower than that in A and C group,and there were statistical differences (P ＜ 0.05).The levels of hs-CRP in A,B,and C group were significantly higher than that in D group:(5.71 ± 1.81),(7.71 ± 2.32) and (4.68 ± 2.09) mg/L vs.(1.60 ± 0.80) mg/L,and there were statistical differences (P＜ 0.01);the level of hs-CRP in B group was significantly higher than that in A and C group,and there were statistical differences (P ＜ 0.05).Correlation analysis results showed that hs-CRP and HDL-C had signficant negative correlation (r =-0.304,P ＜ 0.01),and hs-CRP and LDL-C had signficant positive correlation (r =0.341,P ＜ 0.01),hs-CRP and triacylglycerol (TG) had no correlation (r =0.006,P ＞ 0.05);hs-CRP and fasting plasma glucose (FPG) had signficant positive correlation (r =0.415,P ＜ 0.01),and hs-CRP and glycosylated hemoglobin (HbA1c) had signficant positive correlation (r =0.384,P ＜ 0.01).Conclusions The levels of HDL-C in patients with elder patients with simple coronary heart disease and simple type 2 diabetes mellitus are significantly lower,and the levels of hs-CRP are significantly higher.The level of HDL-C in elder coronary heart disease patients combined with type 2 diabetes mellitus is significantly lower than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus,and the level of hs-CRP is significantly higher than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus.The level of hs-CRP is HDL-C have signficant negative correlation.

The perforation of pulp floor is common in the treatment of pulpal diseases,but the prognosis is not good.Although light-cured calcium hydroxide was widely-used to treat the perforation of pulp floor in the clinical treatment,its clinical effects were not ideal as expected because the slight leakage along the edge of the filler was prone to cause the relapse of inflammation in the pulp floor area.Thus in recent years,MTA(mineral trioxide aggregate)was adopted in our hospital to repair the perforation of pulp floor.42 cases were selected and observed their clinical effects over one year,and the conclusion was that the success rate with MTA was apparently greater than that with usual repairing material.MTA is a nice repairing material to treat the perforation of pulp floor and is worth of clinical application,for it has better closure and biological compatibility.